Model compounds for metal–protein interaction: crystal structures of seven cadmium(II) complexes of amino-acids and peptides

1973 ◽  
Vol 0 (19) ◽  
pp. 753-754 ◽  
Author(s):  
Richard J. Flook ◽  
Hans C. Freeman ◽  
Christopher J. Moore ◽  
Marcia L. Scudder
Keyword(s):  
Amino Acids ◽  
Crystal Structures ◽  
Protein Interaction ◽  
Model Compounds

Model Compounds for Metal–protein Interaction: Crystal Structures of two Glycylglycylglycine–copper Complexes

Nature ◽  
1962 ◽  
Vol 194 (4835) ◽  
pp. 1237-1239 ◽  
Author(s):  
T. COOPER ◽  
H. C. FREEMAN ◽  
G. ROBINSON ◽  
J. C. SCHOONE
Keyword(s):  
Crystal Structures ◽  
Protein Interaction ◽  
Copper Complexes ◽  
Model Compounds

scholarly journals Structural basis of adhesive binding by desmocollins and desmogleins

2016 ◽  
Vol 113 (26) ◽  
pp. 7160-7165 ◽  
Author(s):  
Oliver J. Harrison ◽  
Julia Brasch ◽  
Gorka Lasso ◽  
Phinikoula S. Katsamba ◽  
Goran Ahlsen ◽  
...  
Keyword(s):  
Amino Acids ◽  
Crystal Structures ◽  
Structural Basis ◽  
Cellular Interactions ◽  
Opposite Charge ◽  
Charged Amino Acids ◽  
Structural Framework ◽  
Classical Cadherins ◽  
Coated Bead

Desmosomes are intercellular adhesive junctions that impart strength to vertebrate tissues. Their dense, ordered intercellular attachments are formed by desmogleins (Dsgs) and desmocollins (Dscs), but the nature of trans-cellular interactions between these specialized cadherins is unclear. Here, using solution biophysics and coated-bead aggregation experiments, we demonstrate family-wise heterophilic specificity: All Dsgs form adhesive dimers with all Dscs, with affinities characteristic of each Dsg:Dsc pair. Crystal structures of ectodomains from Dsg2 and Dsg3 and from Dsc1 and Dsc2 show binding through a strand-swap mechanism similar to that of homophilic classical cadherins. However, conserved charged amino acids inhibit Dsg:Dsg and Dsc:Dsc interactions by same-charge repulsion and promote heterophilic Dsg:Dsc interactions through opposite-charge attraction. These findings show that Dsg:Dsc heterodimers represent the fundamental adhesive unit of desmosomes and provide a structural framework for understanding desmosome assembly.

HYDRATION OF AMINO ACIDS, PEPTIDES, AND MODEL COMPOUNDS

1981 ◽  
Vol 367 (1 Quantum Chemi) ◽  
pp. 132-150 ◽  
Author(s):  
Yvonne Paterson ◽  
George Némethy ◽  
Harold A. Scheraga
Keyword(s):  
Amino Acids ◽  
Model Compounds

Crystal structures and phase transition behavior of Poly(nonamethylene terephthalamide) and its model compounds

Polymer ◽  
2017 ◽  
Vol 116 ◽  
pp. 378-394 ◽  
Author(s):  
Hiroko Yamamoto ◽  
Kohji Tashiro ◽  
Kiyotaka Ishino ◽  
Masahide Takahashi ◽  
Ryokei Endo ◽  
...  
Keyword(s):  
Phase Transition ◽  
Crystal Structures ◽  
Phase Transition Behavior ◽  
Model Compounds ◽  
Transition Behavior

Chiral Ferrocene Amines Derived from Amino Acids and Peptides:  Synthesis, Solution and X-ray Crystal Structures and Electrochemical Investigations

2000 ◽  
Vol 39 (24) ◽  
pp. 5437-5443 ◽  
Author(s):  
Alexandra Hess ◽  
Jan Sehnert ◽  
Thomas Weyhermüller ◽  
Nils Metzler-Nolte
Keyword(s):  
Amino Acids ◽  
Crystal Structures ◽  
X Ray ◽  
Peptides Synthesis ◽  
Synthesis Solution

Structural characterization of folded and extended conformations in peptides containing γ amino acids with proteinogenic side chains: crystal structures of γn, (αγ)n and γγδγ sequences

2015 ◽  
Vol 39 (5) ◽  
pp. 3319-3326 ◽  
Author(s):  
Madhusudana M. B. Reddy ◽  
K. Basuroy ◽  
S. Chandrappa ◽  
B. Dinesh ◽  
B. Vasantha ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Crystal Structures ◽  
Structural Characterization ◽  
Side Chains ◽  
Amino Acid Residues

γn amino acid residues can be incorporated into structures in γn and hybrid sequences containing folded and extended α and δ residues.

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