scholarly journals Monitoring degradation of matrix metalloproteinases-cleavable PEG hydrogels via multiple particle tracking microrheology

Soft Matter ◽  
2013 ◽  
Vol 9 (5) ◽  
pp. 1570-1579 ◽  
Author(s):  
Kelly M. Schultz ◽  
Kristi S. Anseth
Keyword(s):  
Matrix Metalloproteinases ◽  
Particle Tracking ◽  
Peg Hydrogels ◽  
Particle Tracking Microrheology ◽  
Multiple Particle Tracking ◽  
Multiple Particle

Multiple particle tracking

2018 ◽  
Author(s):  
Eric M. Furst ◽  
Todd M. Squires
Keyword(s):  
Brownian Motion ◽  
Best Practices ◽  
Particle Tracking ◽  
Heterogeneous Material ◽  
Quantitative Measurements ◽  
Particle Tracking Microrheology ◽  
Shell Models ◽  
Multiple Particle Tracking ◽  
Microscopy Data ◽  
Multiple Particle

The fundamentals and best practices of multiple particle tracking microrheology are discussed, including methods for producing video microscopy data, analyzing data to obtain mean-squared displacements and displacement correlations, and, critically, the accuracy and errors (static and dynamic) associated with particle tracking. Applications presented include two-point microrheology, methods for characterizing heterogeneous material rheology, and shell models of local (non-continuum) heterogeneity. Particle tracking has a long history. The earliest descriptions of Brownian motion relied on precise observations, and later quantitative measurements, using light microscopy.

Lubricin Interaction With Hyaluronate Promotes Interchain Association Leading to Network Formation

2005 ◽  
Author(s):  
J. R. Torres ◽  
G. D. Jay ◽  
M. L. Warman ◽  
R. M. Laxer ◽  
M. Laderer ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Synovial Fluid ◽  
Particle Tracking ◽  
Network Formation ◽  
Molecular Layering ◽  
Cartilage Surface ◽  
Particle Tracking Microrheology ◽  
Boundary Lubricant ◽  
Multiple Particle Tracking ◽  
Multiple Particle

The present work is the first instance where a novel multiple-particle tracking microrheology technique has been applied to study molecular interactions of clinical significance. Herein we describe the molecular changes due to lubricin-hyaluronate interaction and their effect on mechanical properties of synovial fluid. Along with bulk rheology studies it was found that lubricin, a boundary lubricant, increases the HA network formation conducive to the enhanced molecular layering of HA under stress which results in increased shear thinning. This interaction may also allow HA molecules to bind to the cartilage surface, providing boundary lubrication, by virtue of its interaction with lubricin.

Multiple particle tracking microrheology measured using bi-disperse probe diameters

Soft Matter ◽  
2018 ◽  
Vol 14 (28) ◽  
pp. 5811-5820 ◽  
Author(s):  
Matthew D. Wehrman ◽  
Seth Lindberg ◽  
Kelly M. Schultz
Keyword(s):  
Particle Tracking ◽  
Material Properties ◽  
Length Scales ◽  
Multiple Length Scales ◽  
Particle Tracking Microrheology ◽  
Multiple Particle Tracking ◽  
Different Diameters ◽  
Multiple Particle ◽  
Probe Particles

Multiple particle tracking microrheology using probe particles with different diameters to simultaneous characterize material properties at multiple length scales.

scholarly journals Multiple Particle Tracking Detects Changes in Brain Extracellular Matrix and Predicts Neurodevelopmental Age

ACS Nano ◽  
2021 ◽  
Author(s):  
Michael McKenna ◽  
David Shackelford ◽  
Hugo Ferreira Pontes ◽  
Brendan Ball ◽  
Elizabeth Nance
Keyword(s):  
Extracellular Matrix ◽  
Particle Tracking ◽  
Multiple Particle Tracking ◽  
Multiple Particle ◽  
Brain Extracellular Matrix
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