Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: investigations using a novel fungicide

Soft Matter ◽  
2013 ◽  
Vol 9 (3) ◽  
pp. 715-726 ◽  
Author(s):  
Katrin Knop ◽  
Georges M. Pavlov ◽  
Tobias Rudolph ◽  
Karin Martin ◽  
David Pretzel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

Polymers ◽  
2011 ◽  
Vol 3 (2) ◽  
pp. 779-811 ◽  
Author(s):  
Giulia Bonacucina ◽  
Marco Cespi ◽  
Giovanna Mencarelli ◽  
Gianfabio Giorgioni ◽  
Giovanni Filippo Palmieri
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Self Assembling

Biodegradable block copolymers as injectable drug-delivery systems

Nature ◽  
10.1038/42218 ◽  
1997 ◽  
Vol 388 (6645) ◽  
pp. 860-862 ◽  
Author(s):  
Byeongmoon Jeong ◽  
You Han Bae ◽  
Doo Sung Lee ◽  
Sung Wan Kim
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Injectable Drug

scholarly journals Dual Responsive Polymersomes for Gold Nanorod and Doxorubicin Encapsulation: Nanomaterials with Potential Use as Smart Drug Delivery Systems

Polymers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 939 ◽  
Author(s):  
Melissa DiazDuarte-Rodriguez ◽  
Norma A. Cortez-Lemus ◽  
Angel Licea-Claverie ◽  
Jacob Licea-Rodriguez ◽  
Eugenio R. Méndez
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Delivery Systems ◽  
Dual Responsive ◽  
Poly Ethylene ◽  
Potential Use

In the present study, poly(ethylene glycol)-b-poly(N,N-diethylaminoethyl methacrylate) (PEG-b-PDEAEM) amphiphilic block copolymers were synthetized by reversible addition-fragmentation chain transfer (RAFT) polymerization using two different macro chain transfer agents containing PEG of 2000 and 5000 g/mol and varying the length of the PDEAEM segment. From the obtained block copolymers, polymersome type nanometric aggregates were obtained by two different techniques. By direct dispersion, particle diameters around 200 nm were obtained, while by solvent exchange using THF and water, the obtained diameters were around 100 nm. These block copolymers were used to encapsulate gold nanorods and doxorubicin (DOX) with good efficiencies to obtain nanomaterials with potential use as dual stimuli-sensitive drug delivery systems for combined anticancer therapies. Drug delivery studies showed that the release rate of DOX was accelerated when the pH was lowered from 7.4 to 5.8 and also when the systems were irradiated with a NIR laser at pH 7.4. The combination of lower pH and near infrared (NIR) irradiation resulted in higher drug release only in the case of polymersomes with lower molecular weight PEG.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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