The facile synthesis of 2-bromoindoles via Cs2CO3-promoted intramolecular cyclization of 2-(gem-dibromovinyl)anilines under transition-metal-free conditions

RSC Advances ◽  
2013 ◽  
Vol 3 (1) ◽  
pp. 73-78 ◽  
Author(s):  
Pinhua Li ◽  
Yong Ji ◽  
Wei Chen ◽  
Xiuli Zhang ◽  
Lei Wang
Keyword(s):  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Facile Synthesis ◽  
Metal Free

scholarly journals Transition-metal-free base catalyzed intramolecular cyclization of 2-ynylphenols for efficient and facile synthesis of 2-substituted benzo[b]furans

RSC Advances ◽  
2018 ◽  
Vol 8 (50) ◽  
pp. 28637-28641 ◽  
Author(s):  
Yong Liu ◽  
Tao Lu ◽  
Wei-Fang Tang ◽  
Jian Gao
Keyword(s):  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Free Base ◽  
Facile Synthesis ◽  
Metal Free

An efficient and practical transition-metal-free synthesis of 2-substituted benzo[b]furans catalyzed by readily accessible base was developed with broad substrates scope.

Transition-metal-free and facile synthesis of 3-alkynylpyrrole-2, 4-dicarboxylates from methylene isocyanides and propiolaldehyde

2021 ◽  
Author(s):  
Xiaoli Huo ◽  
Xiaojuan Chen ◽  
Liya Yu ◽  
Chong Zhang ◽  
Linghui Zeng ◽  
...  
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Transformation Process ◽  
Facile Synthesis ◽  
Direct Transformation ◽  
Metal Free

A transition-metal-free, facile and efficient method for the synthesis of 3-alkynylpyrrole-2, 4-dicarboxylates from methylene isocyanides and propiolaldehyde with moderate to good yields has been developed. The direct transformation process and...

Visible light driven metal-free intramolecular cyclization: a facile synthesis of 3-position substituted 3,4-dihydroisoquinolin-1(2H)-one

2019 ◽  
Vol 17 (2) ◽  
pp. 380-387 ◽  
Author(s):  
Shuai Zou ◽  
Shu Geng ◽  
Lina Chen ◽  
Haitao Wang ◽  
Feng Huang
Keyword(s):  
Visible Light ◽  
Intramolecular Cyclization ◽  
Facile Synthesis ◽  
Metal Free ◽  
Visible Light Driven

Visible light driven metal-free intramolecular cyclization: a facile synthesis of 3-position substituted 3,4-dihydroisoquinolin-1(2H)-one.

Access to Furo[2,3‐ b ]pyridines by Transition‐Metal‐Free Intramolecular Cyclization of C3‐substituted Pyridine N ‐oxides

2018 ◽  
Vol 7 (5) ◽  
pp. 879-882 ◽  
Author(s):  
Dong Wang ◽  
Meng Shen ◽  
Yuxi Wang ◽  
Jianyong Hu ◽  
Junjie Zhao ◽  
...  
Keyword(s):  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Metal Free

Synthesis of Imidazo[1,5-a]quinolines via Metal-Free Oxidative Amination of sp3 C–H Bonds

Synthesis ◽  
2018 ◽  
Vol 50 (14) ◽  
pp. 2761-2767 ◽  
Author(s):  
Chen Ma ◽  
Huanhuan Liu ◽  
Xinfeng Wang
Keyword(s):  
Amino Acids ◽  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Efficient Synthesis ◽  
Oxidative Amination ◽  
Metal Free ◽  
Oxidation System

A novel oxidative amination of sp3 C–H bonds was developed for the efficient synthesis of imidazo[1,5-a]quinolines from readily available α-amino acids and (2-azaaryl)methanes. This domino protocol, which was established in a TBAI-TBHP oxidation system, includes transition-metal-free decarboxylation and intramolecular cyclization. This method represented a new avenue for the synthesis of N-heterocycles using 2-methylquinolines as the synthon of quinoline-2-carbaldehydes.

scholarly journals Base-Catalyzed Synthesis of Flavones via Thiol-Assisted Sequential Demethylation/Cyclization of 1-(2-methoxyphenyl)prop-2-yn-1-ones

2021 ◽  
Author(s):  
Ritiele Heck ◽  
Thiago Anjos ◽  
Maira R Giehl ◽  
Ricardo F Schumacher ◽  
Benhur Godoi
Keyword(s):  
Reaction Time ◽  
Secondary Metabolites ◽  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Important Class ◽  
Short Reaction Time ◽  
Metal Free ◽  
Synthetic Strategy ◽  
Pharmacologically Active ◽  
Active Substances

Flavone and analogues represent an important class of biologically and pharmacologically active substances commonly found in the composition of diverse plants as part of the class of secondary metabolites. Herein, we have demonstrated an efficient and regioselective synthetic strategy for the preparation of functionalized flavones through sequential demethylation/6-endo-dig intramolecular cyclization of propyn-1-ones, using catalytic amounts of base in the presence of a thiol, by employing NMP as the solvent. The reactions proceeded smoothly under transition-metal-free and open to air conditions, furnishing the desired six-membered heterocycles in moderate to excellent yields, in short reaction time.

Facile synthesis of 4-quinolone derivatives via one-pot cascade reaction under transition-metal-free conditions

2015 ◽  
Vol 56 (24) ◽  
pp. 3777-3781 ◽  
Author(s):  
Chao Huang ◽  
Jia-Hui Guo ◽  
Huang-Mei Fu ◽  
Ming-Long Yuan ◽  
Li-Juan Yang
Keyword(s):  
Transition Metal ◽  
Cascade Reaction ◽  
Facile Synthesis ◽  
One Pot ◽  
Metal Free ◽  
Quinolone Derivatives

Transition-metal free synthesis of N-Aryl carbazoles and their extended analogs

2021 ◽  
Author(s):  
Mikhail Feofanov ◽  
Vladimir Akhmetov ◽  
Ryo Takayama ◽  
Konstantin Amsharov
Keyword(s):  
Transition Metal ◽  
Facile Synthesis ◽  
Nucleophilic Substitutions ◽  
Metal Free ◽  
Electronic Transfer

Herein, we describe a facile synthesis of the N-arylated carbazoles via ladderization of fluorinated oligophenylenes. The reaction consists of two subsequent nucleophilic substitutions triggered by the electronic transfer from dimsyl...

Intramolecular cyclization of diarylmethanols and α,β-unsaturated amides promoted by KOt-Bu/DMF: a metal-free approach towards 3,4-disubstituted quinolinones

2016 ◽  
Vol 14 (47) ◽  
pp. 11148-11153 ◽  
Author(s):  
Jia-hua Chen ◽  
Zi-cong Chen ◽  
Hong Zhao ◽  
Yong Zou ◽  
Xue-jing Zhang ◽  
...  
Keyword(s):  
Intramolecular Cyclization ◽  
Facile Synthesis ◽  
Metal Free

A facile synthesis of 3,4-disubstituted quinolinones had been developed via KOt-Bu/DMF promoted intramolecular addition of diarylmethanols to α,β-unsaturated amides.

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