Amino/quaternary ammonium groups bifunctionalized large pore mesoporous silica for pH-responsive large drug delivery

RSC Advances ◽  
2012 ◽  
Vol 2 (10) ◽  
pp. 4421 ◽  
Author(s):  
Haoquan Zheng ◽  
Shunai Che
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Quaternary Ammonium ◽  
Ph Responsive ◽  
Large Pore

scholarly journals pH-responsive mesoporous silica drug delivery system, its biocompatibility and co-adsorption/co-release of 5-Fluorouracil and Naproxen

2021 ◽  
pp. 150011
Author(s):  
Eva Benova ◽  
Virginie Hornebecq ◽  
Vladimír Zelenak ◽  
Veronika Huntosova ◽  
Miroslav Almasi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Co Adsorption ◽  
Ph Responsive

scholarly journals pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 460
Author(s):  
Minja Mladenović ◽  
Ibrahim Morgan ◽  
Nebojša Ilić ◽  
Mohamad Saoud ◽  
Marija V. Pergal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Inductively Coupled Plasma ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Emission Spectrometry ◽  
Ph Responsive

Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.

scholarly journals pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

2017 ◽  
Vol 4 (4) ◽  
pp. 3 ◽  
Author(s):  
Miguel Gisbert-Garzarán ◽  
Miguel Manzano ◽  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Carbon Nanoparticles ◽  
Ph Responsive

scholarly journals Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1797-1805 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

scholarly journals Construction of a pH-responsive drug delivery platform based on the hybrid of mesoporous silica and chitosan

2021 ◽  
Vol 25 (1) ◽  
pp. 101174
Author(s):  
Keliang Zhang ◽  
Jun Gao ◽  
Shangji Li ◽  
Ting Ma ◽  
Linhong Deng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Ph Responsive ◽  
Delivery Platform

Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs

2015 ◽  
Vol 44 (46) ◽  
pp. 20186-20192 ◽  
Author(s):  
Haoquan Zheng ◽  
Cheuk-Wai Tai ◽  
Jie Su ◽  
Xiaodong Zou ◽  
Feifei Gao
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Electrostatic Interactions ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Responsive ◽  
Drug Molecule ◽  
Drug Molecules ◽  
Anti Cancer

A pH-responsive drug delivery system via mesoporous silica nanoparticles as carriers can be achieved based on electrostatic interactions between drug molecules and carriers, when the isoelectric point of the drug molecule is high.

scholarly journals Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery

Nanoscale ◽  
2015 ◽  
Vol 7 (16) ◽  
pp. 7178-7183 ◽  
Author(s):  
Isurika R. Fernando ◽  
Daniel P. Ferris ◽  
Marco Frasconi ◽  
Dmitry Malin ◽  
Elena Strekalova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Amino Ester ◽  
Stimuli Responsive ◽  
Ph Responsive

Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved.

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