Facile hydrothermal synthesis of low generation dendrimer-stabilized gold nanoparticles for in vivo computed tomography imaging applications

2013 ◽  
Vol 4 (6) ◽  
pp. 1788 ◽  
Author(s):  
Hui Liu ◽  
Yanhong Xu ◽  
Shihui Wen ◽  
Jingyi Zhu ◽  
Linfeng Zheng ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Hydrothermal Synthesis ◽  
Computed Tomography Imaging ◽  
Tomography Imaging

Light-triggered crosslinking of gold nanoparticles for remarkably improved radiation therapy and computed tomography imaging of tumors

Nanomedicine ◽  
2019 ◽  
Vol 14 (22) ◽  
pp. 2941-2955 ◽  
Author(s):  
Xiaju Cheng ◽  
Rui Sun ◽  
Huawei Xia ◽  
Jianan Ding ◽  
Ling Yin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Folic Acid ◽  
Tumor Targeting ◽  
Poly Ethylene Glycol ◽  
Computed Tomography Imaging ◽  
Tomography Imaging ◽  
Poly Ethylene ◽  
Targeting Ability

Aim: We aimed to characterize the tumor-targeting and radiosensitization properties of the photo-responsive gold nanoparticles (AuNPs) decorated photolabile diazirine group and folic acid for improved radiotherapy and computed tomography imaging of tumors. Methods: Folic acid and photolabile diazirine group were covalently conjugated on the surface of AuNPs to afford the desired photo-responsive dAuNP-FA (AuNPs capped with poly(ethylene) glycol ligands bearing photolabile diazirine group and folic acid). The probes were intravenously injected into tumor-bearing mice followed by photocrosslinking upon 405 nm laser irradiation for radiotherapy and computed tomography imaging of tumors in vivo. Results: Light-triggered crosslinking of AuNPs in vivo remarkably enhanced the accumulation and retention of AuNPs within tumors. Conclusion: We have successfully developed a novel photo-responsive Au particle-based tumor theranostic probe showing remarkably improved tumor targeting ability and radiosensitization effect.

Antibiofouling Polymer-Coated Gold Nanoparticles as a Contrast Agent for in Vivo X-ray Computed Tomography Imaging

2007 ◽  
Vol 129 (24) ◽  
pp. 7661-7665 ◽  
Author(s):  
Dongkyu Kim ◽  
Sangjin Park ◽  
Jae Hyuk Lee ◽  
Yong Yeon Jeong ◽  
Sangyong Jon
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agent ◽  
Computed Tomography Imaging ◽  
X Ray ◽  
Tomography Imaging ◽  
X Ray Computed

Alginate hydrogel co-loaded with cisplatin and gold nanoparticles for computed tomography image-guided chemotherapy

2018 ◽  
Vol 33 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Marzieh Keshavarz ◽  
Kave Moloudi ◽  
Reza Paydar ◽  
Ziaeddin Abed ◽  
Jaber Beik ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Colon Adenocarcinoma ◽  
Imaging Study ◽  
Alginate Hydrogel ◽  
Computed Tomography Imaging ◽  
Tomography Imaging ◽  
Computed Tomography Images ◽  
Expected Benefits

The biomedical applications of gold nanoparticles (AuNPs) have experienced rapid growth in recent years, due to their expected benefits in medical imaging and therapy. In this work, we report the development of a theranostic nanocomplex constructed from alginate hydrogel co-loaded with cisplatin and AuNPs (abbreviated as ACA) for simultaneous drug delivery and computed tomography imaging. CT26 cells derived from mouse colon adenocarcinoma were exposed to various concentrations of ACA nanocomplex (for 24 h) and the cytotoxicity was measured using MTT assay. Moreover, the cells treated with ACA nanocomplex were imaged in a computed tomography scanner and the contrast enhancement due to the presence of nanocomplex was assessed. The cytotoxicity results showed that ACA nanocomplex had a more potent chemotherapy efficacy than free cisplatin, so that ACA nanocomplex at the concentration of 5 µg/ml (per cisplatin) and 20 µg/ml of free cisplatin resulted in the same cytotoxicity (survival rate: 66%). The computed tomography imaging study revealed that ACA nanocomplex increased the brightness of computed tomography images, the computed tomography number value, and contrast-to-noise ratio (CNR). ACA nanocomplex can be presented as a computed tomography-traceable nanocarrier that allows to monitor the delivery of therapeutics by assessing their localized accumulation and in vivo biodistribution.

Metabolizable dopamine-coated gold nanoparticle aggregates: preparation, characteristics, computed tomography imaging, acute toxicity, and metabolism in vivo

2016 ◽  
Vol 4 (6) ◽  
pp. 1090-1099 ◽  
Author(s):  
Yao Yu ◽  
Youshen Wu ◽  
Jiajun Liu ◽  
Ke Li ◽  
Daocheng Wu
Keyword(s):  
Computed Tomography ◽  
Acute Toxicity ◽  
Gold Nanoparticle ◽  
Circulation Time ◽  
Computed Tomography Imaging ◽  
Lower Toxicity ◽  
Tomography Imaging ◽  
Imaging Results ◽  
Nanoparticle Aggregates

We prepared metabolizable MSA AuNPs@DPA aggregates, which exhibit improved CT imaging results, much lower toxicity and much longer circulation time in vivo.

CMR 2007: 8.03: Gold nanoparticles as contrast agents for MRI and X-ray computed tomography imaging

2007 ◽  
Vol 2 (6) ◽  
pp. 292-293
Author(s):  
S. Roux ◽  
C. Alric ◽  
J. Taleb ◽  
C. Mandon ◽  
C. Billotey ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Computed Tomography Imaging ◽  
X Ray ◽  
Tomography Imaging ◽  
X Ray Computed
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