Development of a new cascade reaction for convergent synthesis of pyrazolo[1,5-a]quinoline derivatives under transition-metal-free conditions

2013 ◽  
Vol 11 (7) ◽  
pp. 1171 ◽  
Author(s):  
Jun-ya Kato ◽  
Hiroshi Aoyama ◽  
Tsutomu Yokomatsu
Keyword(s):  
Transition Metal ◽  
Cascade Reaction ◽  
Quinoline Derivatives ◽  
Convergent Synthesis ◽  
Metal Free

A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to assemble diphosphonyl xanthene derivatives

2021 ◽  
Author(s):  
Tao Fan ◽  
Yan Liu ◽  
Caina Jiang ◽  
Yanli Xu ◽  
Yan-Yan Chen
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Cascade Reaction ◽  
Phosphine Oxides ◽  
Metal Free ◽  
Mild Conditions ◽  
Xanthene Derivatives ◽  
Reaction Proceeds ◽  
Radical Cascade

A radical cascade reaction of 2-aryloxy phenylacetylene with phosphine oxides promoted by K2S2O8 was developed, provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with...

A transition-metal-free multicomponent reaction towards constructing chiral 2H-1,4-benzoxazine scaffolds

2020 ◽  
Vol 22 (21) ◽  
pp. 7506-7512
Author(s):  
Lixiang Zhu ◽  
Xiaoyu Ren ◽  
Juan Du ◽  
Jia-Hong Wu ◽  
Jian-Ping Tan ◽  
...  
Keyword(s):  
Transition Metal ◽  
Multicomponent Reaction ◽  
Phosphonium Salt ◽  
Cascade Reaction ◽  
Metal Free

A transition-metal-free multicomponent cascade reaction of α-halogenated ketones, ortho-aminophenols, and aldehydes using a dipeptide phosphonium salt catalyst was developed for the construction of various 2H-1,4-benzoxazines.

Stereoselective three-component cascade synthesis of α-substituted 2,4-dienamides from gem-difluorochloro ethanes

2019 ◽  
Vol 55 (95) ◽  
pp. 14355-14358
Author(s):  
Shyamsundar Das ◽  
Nakeun Ko ◽  
Eunsung Lee ◽  
Sang Eun Kim ◽  
Byung Chul Lee
Keyword(s):  
Transition Metal ◽  
Claisen Rearrangement ◽  
Cascade Reaction ◽  
One Pot ◽  
Metal Free

Herein, we describe a new transition metal-free Claisen rearrangement for the synthesis of α-substituted 2,4-dienamide. This one-pot, stereoselective three-component cascade reaction affords various polysubstituted 2,4-dienamides in good yields.

One-pot transition-metal-free cascade synthesis of thieno[2,3-c]coumarins from chromones

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 103895-103898 ◽  
Author(s):  
Yuhong Yang ◽  
Xueyu Qi ◽  
Ruiling Liu ◽  
Qian He ◽  
Chunhao Yang
Keyword(s):  
Transition Metal ◽  
Cascade Reaction ◽  
Free Base ◽  
One Pot ◽  
Metal Free

A one-pot transition-metal-free, base-mediated synthesis of a novel series of functionalized thieno[2,3-c]coumarins has been developed through a cascade reaction from chromones.

Diversity-Oriented Synthesis of Functionalized Imidazopyridine Analogues with Anti-Cancer Activity through a Transition-Metal Free, One-pot Cascade Reaction

2018 ◽  
Vol 360 (19) ◽  
pp. 3655-3661 ◽  
Author(s):  
Gui-Ting Song ◽  
Nicholas McConnell ◽  
Zhong-Zhu Chen ◽  
Xiao-Fang Yao ◽  
Jiu-Hong Huang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Cascade Reaction ◽  
One Pot ◽  
Diversity Oriented Synthesis ◽  
Metal Free ◽  
Anti Cancer ◽  
Cancer Activity

Metal-free sulfonyl radical-initiated cascade cyclization to access sulfonated indolo[1,2-a]quinolines

2019 ◽  
Vol 55 (84) ◽  
pp. 12615-12618 ◽  
Author(s):  
Kai Sun ◽  
Xiao-Lan Chen ◽  
Yin-Li Zhang ◽  
Kai Li ◽  
Xian-Qiang Huang ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Quinoline Derivatives ◽  
Metal Free ◽  
Cascade Cyclization

A metal-free cascade reaction was developed for the synthesis of indolo[1,2-a]quinoline derivatives from arylsulfonyl hydrazides and 1-(2-(arylethynyl)phenyl)indoles in the presence of TBAI/TBHP.

Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides

2016 ◽  
Vol 18 (9) ◽  
pp. 1992-1995 ◽  
Author(s):  
Alessandro Gesù ◽  
Claudio Pozzoli ◽  
Enza Torre ◽  
Silvio Aprile ◽  
Tracey Pirali
Keyword(s):  
Transition Metal ◽  
Cascade Reaction ◽  
Metal Free

BPO-promoted direct oxidative C–H functionalization of unactivated alkanes into 6-alkyl-6H-benzo[c]chromenes under transition-metal-free conditions

2019 ◽  
Vol 17 (33) ◽  
pp. 7715-7722 ◽  
Author(s):  
Lei Ji ◽  
Qinfei Deng ◽  
Ping Liu ◽  
Peipei Sun
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Cascade Reaction ◽  
Vinyl Ethers ◽  
Metal Free

A simple and efficient BPO-promoted free radical-based cascade reaction of biaryl vinyl ethers with easily available unactivated alkanes has been developed.

Facile synthesis of 4-quinolone derivatives via one-pot cascade reaction under transition-metal-free conditions

2015 ◽  
Vol 56 (24) ◽  
pp. 3777-3781 ◽  
Author(s):  
Chao Huang ◽  
Jia-Hui Guo ◽  
Huang-Mei Fu ◽  
Ming-Long Yuan ◽  
Li-Juan Yang
Keyword(s):  
Transition Metal ◽  
Cascade Reaction ◽  
Facile Synthesis ◽  
One Pot ◽  
Metal Free ◽  
Quinolone Derivatives
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