Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst

2012 ◽  
Vol 10 (11) ◽  
pp. 2209 ◽  
Author(s):  
Tsuyoshi Miura ◽  
Hikaru Kasuga ◽  
Kie Imai ◽  
Mariko Ina ◽  
Norihiro Tada ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Asymmetric Aldol ◽  
Highly Efficient ◽  
Asymmetric Aldol Reaction

scholarly journals Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 648
Author(s):  
Yu-Hao Zhou ◽  
Yu-Zu Zhang ◽  
Zhu-Lian Wu ◽  
Tian Cai ◽  
Wei Wen ◽  
...  
Keyword(s):  
Primary Amine ◽  
Aldol Reaction ◽  
Enantioselective Synthesis ◽  
Asymmetric Aldol ◽  
Highly Efficient ◽  
Asymmetric Aldol Reaction ◽  
Aldol Addition ◽  
High Yields

A highly efficient quinine-derived primary-amine-catalyzed asymmetric aldol addition of hydroxyacetone to arylglyoxals is described. Structurally diverse anti-2,3-dihydroxy-1,4-diones were generated in high yields, with good diastereoselectivities and enantioselectivities.

ChemInform Abstract: Highly Efficient Asymmetric Aldol Reaction in Brine Using a Fluorous Sulfonamide Organocatalyst.

ChemInform ◽  
2012 ◽  
Vol 43 (32) ◽  
pp. no-no
Author(s):  
Tsuyoshi Miura ◽  
Hikaru Kasuga ◽  
Kie Imai ◽  
Mariko Ina ◽  
Norihiro Tada ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Asymmetric Aldol ◽  
Highly Efficient ◽  
Asymmetric Aldol Reaction

The Ion Tag Strategy as a Route to Highly Efficient Organocatalysts for the Direct Asymmetric Aldol Reaction

2009 ◽  
Vol 351 (1-2) ◽  
pp. 276-282 ◽  
Author(s):  
Marco Lombardo ◽  
Srinivasan Easwar ◽  
Filippo Pasi ◽  
Claudio Trombini
Keyword(s):  
Aldol Reaction ◽  
Asymmetric Aldol ◽  
Highly Efficient ◽  
Asymmetric Aldol Reaction

Highly efficient organocatalysts for the asymmetric aldol reaction

2018 ◽  
Vol 42 (9) ◽  
pp. 7416-7421 ◽  
Author(s):  
C. G. Jacoby ◽  
P. H. V. Vontobel ◽  
M. F. Bach ◽  
P. H. Schneider
Keyword(s):  
Aldol Reaction ◽  
Synthetic Route ◽  
Asymmetric Aldol ◽  
New Class ◽  
Highly Efficient ◽  
Asymmetric Aldol Reaction

A new class of bifunctional organocatalysts containing both thiazolidine/pyrrolidine and imidazole cycles was prepared via a readily available synthetic route.

Novel chiral proline-based organocatalysts with amide and thiourea–amine units for highly efficient asymmetric aldol reaction in saturated brine without additives

2019 ◽  
Vol 97 (5) ◽  
pp. 352-359
Author(s):  
En-Jie Xu ◽  
Yan Song ◽  
Zhong-Lin Wei ◽  
Rui Wang ◽  
Hai-Feng Duan ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Aldol Reaction ◽  
Asymmetric Aldol ◽  
Highly Efficient ◽  
Asymmetric Aldol Reaction ◽  
Benzaldehyde Derivatives

A series of novel proline-based organocatalysts with amide and thiourea-amine units (7a–7f) were developed and evaluated in the asymmetric aldol reaction of 4-nitrobenzaldehyde with cyclohexanone. The organocatalyst (7c or 7d, 5 mol%) exhibited efficient catalytic activity to afford aldol products in high diastereoselectivity (up to >99:1), enantioselectivity (up to >99%), and yield (up to >96%) at 0 °C in saturated brine without adding an acid. Aldol products of benzaldehyde derivatives almost universally provide high diastereoselectivity and enantioselectivity.

Highly efficient primary amine organocatalysts for the direct asymmetric aldol reaction in brine

2009 ◽  
Vol 20 (12) ◽  
pp. 1419-1424 ◽  
Author(s):  
Xiao Ma ◽  
Chao-Shan Da ◽  
Lei Yi ◽  
Ya-Ning Jia ◽  
Qi-Peng Guo ◽  
...  
Keyword(s):  
Primary Amine ◽  
Aldol Reaction ◽  
Asymmetric Aldol ◽  
Highly Efficient ◽  
Asymmetric Aldol Reaction

ChemInform Abstract: Highly Efficient Prolinamide-Based Organocatalysts for the Direct Asymmetric Aldol Reaction in Brine.

ChemInform ◽  
2009 ◽  
Vol 40 (39) ◽  
Author(s):  
Ya-Ning Jia ◽  
Feng-Chun Wu ◽  
Xiao Ma ◽  
Gong-Jian Zhu ◽  
Chao-Shan Da
Keyword(s):  
Aldol Reaction ◽  
Asymmetric Aldol ◽  
Highly Efficient ◽  
Asymmetric Aldol Reaction
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