Design and synthesis of novel N,N′-glycoside derivatives of 3,3′-diindolylmethanes as potential antiproliferative agents

MedChemComm ◽  
2012 ◽  
Vol 3 (9) ◽  
pp. 1082 ◽  
Author(s):  
Deepak K. Sharma ◽  
Bilal Rah ◽  
Mallikharjuna R. Lambu ◽  
Altaf Hussain ◽  
Syed K. Yousuf ◽  
...  
Keyword(s):  
Antiproliferative Agents ◽  
Design And Synthesis ◽  
Derivatives Of

Design and Synthesis of Novel 20(S)-α-aminophosphonate Derivatives of Camptothecin as Potent Antitumor Agents

2021 ◽  
pp. 105065
Author(s):  
Yu-Yuan Chen ◽  
Yin-Peng Bai ◽  
Bin Li ◽  
Xiao-Bo Zhao ◽  
Cheng-Jie Yang ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Design And Synthesis ◽  
Derivatives Of

Design and synthesis of herboxidiene derivatives that potently inhibit in vitro splicing

2021 ◽  
Vol 19 (6) ◽  
pp. 1365-1377
Author(s):  
Arun K. Ghosh ◽  
Srinivasa Rao Allu ◽  
Guddeti Chandrashekar Reddy ◽  
Adriana Gamboa Lopez ◽  
Patricia Mendez ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design And Synthesis ◽  
In Vitro Splicing ◽  
Enantioselective Syntheses ◽  
Derivatives Of

Enantioselective syntheses of C-6 modified derivatives of herboxidiene and their biological evaluation in splicing inhibitory assay.

Design and Synthesis of New [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Potential Antiproliferative Agents

2015 ◽  
Vol 36 (7) ◽  
pp. 1863-1873 ◽  
Author(s):  
Ahmed Elkamhawy ◽  
Mohammad M. Al-Sanea ◽  
Chiman Song ◽  
Taebo Sim ◽  
Eun Joo Roh
Keyword(s):  
Pyrimidine Derivatives ◽  
Antiproliferative Agents ◽  
Design And Synthesis

scholarly journals Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6798
Author(s):  
Essmat M. El-Sheref ◽  
Mohammed A. I. Elbastawesy ◽  
Alan B. Brown ◽  
Ahmed M. Shawky ◽  
Hesham A. M. Gomaa ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Click Reaction ◽  
Annexin V ◽  
Antiproliferative Agents ◽  
Design And Synthesis ◽  
Cycle Arrest ◽  
M Phase ◽  
Reaction Potential ◽  
Apoptotic Activity ◽  
Mcf 7

A mild and versatile method based on Cu-catalyzed [2+3] cycloaddition (Huisgen-Meldal-Sharpless reaction) was developed to tether 3,3’-((4-(prop-2-yn-1-yloxy)phenyl)methylene)bis(4-hydroxyquinolin-2(1H)-ones) with 4-azido-2-quinolones in good yields. This methodology allowed attaching three quinolone molecules via a triazole linker with the proposed mechanism. The products are interesting precursors for their anti-proliferative activity. Compound 8g was the most active one, achieving IC50 = 1.2 ± 0.2 µM and 1.4 ± 0.2 µM against MCF-7 and Panc-1 cell lines, respectively. Moreover, cell cycle analysis of cells MCF-7 treated with 8g showed cell cycle arrest at the G2/M phase (supported by Caspase-3,8,9, Cytochrome C, BAX, and Bcl-2 studies). Additionally, significant pro-apoptotic activity is indicated by annexin V-FITC staining.

Design and synthesis of novel water-soluble amino acid derivatives of chlorin p6 ethers as photosensitizer

2019 ◽  
Vol 30 (1) ◽  
pp. 247-249 ◽  
Author(s):  
Xingjie Zhang ◽  
Zhi Meng ◽  
Zhiqiang Ma ◽  
Junhong Liu ◽  
Guiyan Han ◽  
...  
Keyword(s):  
Amino Acid ◽  
Water Soluble ◽  
Amino Acid Derivatives ◽  
Design And Synthesis ◽  
Derivatives Of ◽  
Chlorin P6

Design and Synthesis of Novel Urea Derivatives of Pyrimidine-Pyrazoles as Anticancer Agents

2021 ◽  
pp. 131937
Author(s):  
Purna Koteswara Rao Cherukumalli ◽  
Bhaskara Rao Tadiboina ◽  
Kali Charan Gulipalli ◽  
Srinu Bodige ◽  
Vishnu Nayak Badavath ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Urea Derivatives ◽  
Design And Synthesis ◽  
Derivatives Of

Design and Synthesis of Novel Benzopyran-2-one Derivatives of Expected Antimicrobial Activity through DNA Gyrase-B Inhibition

2008 ◽  
Vol 341 (11) ◽  
pp. 725-733 ◽  
Author(s):  
Ghaneya S. Hassan ◽  
Nahla A. Farag ◽  
Gehan H. Hegazy ◽  
Reem K. Arafa
Keyword(s):  
Antimicrobial Activity ◽  
Dna Gyrase ◽  
Design And Synthesis ◽  
Derivatives Of

scholarly journals Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer

2016 ◽  
Vol 118 ◽  
pp. 230-243 ◽  
Author(s):  
Marcella Bassetto ◽  
Salvatore Ferla ◽  
Fabrizio Pertusati ◽  
Sahar Kandil ◽  
Andrew D. Westwell ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Antiproliferative Agents ◽  
Design And Synthesis
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