Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes

2013 ◽  
Vol 9 (2) ◽  
pp. 307-317 ◽  
Author(s):  
Prabhjit Kaur ◽  
Nasser Rizk ◽  
Sereen Ibrahim ◽  
Yue Luo ◽  
Noura Younes ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Arabinoxylan Attenuates Type 2 Diabetes by Improvement of Carbohydrate, Lipid, and Amino Acid Metabolism

2018 ◽  
Vol 62 (20) ◽  
pp. 1800222 ◽  
Author(s):  
Qixing Nie ◽  
Haihong Chen ◽  
Jielun Hu ◽  
He Gao ◽  
Linlin Fan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Zanthoxylum alkylamides improve amino acid metabolism in type 2 diabetes mellitus rats

2020 ◽  
Vol 44 (10) ◽  
Author(s):  
Xunyu Wei ◽  
Bing Yang ◽  
Guangjing Chen ◽  
Di Wang ◽  
Yue Shi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

scholarly journals Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent

2021 ◽  
Vol 9 (1) ◽  
pp. e002298
Author(s):  
Danielle E Haslam ◽  
Liming Liang ◽  
Dong D Wang ◽  
Rachel S Kelly ◽  
Clemens Wittenbecher ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Amino Acid ◽  
Puerto Rican ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Meta Analysis ◽  
Random Effect ◽  
Plasma Metabolites ◽  
Blood Draw

IntroductionWe investigated whether network analysis revealed clusters of coregulated metabolites associated with prevalent type 2 diabetes (T2D) among Puerto Rican adults.Research design and methodsWe used liquid chromatography-mass spectrometry to measure fasting plasma metabolites (>600) among participants aged 40–75 years in the Boston Puerto Rican Health Study (BPRHS; discovery) and San Juan Overweight Adult Longitudinal Study (SOALS; replication), with (n=357; n=77) and without (n=322; n=934) T2D, respectively. Among BPRHS participants, we used unsupervised partial correlation network-based methods to identify and calculate metabolite cluster scores. Logistic regression was used to assess cross-sectional associations between metabolite clusters and prevalent T2D at the baseline blood draw in the BPRHS, and significant associations were replicated in SOALS. Inverse-variance weighted random-effect meta-analysis was used to combine cohort-specific estimates.ResultsSix metabolite clusters were significantly associated with prevalent T2D in the BPRHS and replicated in SOALS (false discovery rate (FDR) <0.05). In a meta-analysis of the two cohorts, the OR and 95% CI (per 1 SD increase in cluster score) for prevalent T2D were as follows for clusters characterized primarily by glucose transport (0.21 (0.16 to 0.30); FDR <0.0001), sphingolipids (0.40 (0.29 to 0.53); FDR <0.0001), acyl cholines (0.35 (0.22 to 0.56); FDR <0.0001), sugar metabolism (2.28 (1.68 to 3.09); FDR <0.0001), branched-chain and aromatic amino acids (2.22 (1.60 to 3.08); FDR <0.0001), and fatty acid biosynthesis (1.54 (1.29 to 1.85); FDR <0.0001). Three additional clusters characterized by amino acid metabolism, cell membrane components, and aromatic amino acid metabolism displayed significant associations with prevalent T2D in the BPRHS, but these associations were not replicated in SOALS.ConclusionsAmong Puerto Rican adults, we identified several known and novel metabolite clusters that associated with prevalent T2D.

scholarly journals Metabolomic Profiling of Fatty Acid and Amino Acid Metabolism in Youth With Obesity and Type 2 Diabetes: Evidence for enhanced mitochondrial oxidation

Diabetes Care ◽  
2012 ◽  
Vol 35 (3) ◽  
pp. 605-611 ◽  
Author(s):  
S. J. Mihalik ◽  
S. F. Michaliszyn ◽  
J. de las Heras ◽  
F. Bacha ◽  
S. Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acid ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Metabolomic Profiling ◽  
Mitochondrial Oxidation

Front cover: Arabinoxylan Attenuates Type 2 Diabetes by Improvement of Carbohydrate, Lipid, and Amino Acid Metabolism

2018 ◽  
Vol 62 (20) ◽  
pp. 1870090
Author(s):  
Qixing Nie ◽  
Haihong Chen ◽  
Jielun Hu ◽  
He Gao ◽  
Linlin Fan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Front Cover

scholarly journals Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery

Diabetologia ◽  
2015 ◽  
Vol 58 (8) ◽  
pp. 1845-1854 ◽  
Author(s):  
Jakob S. Hansen ◽  
Xinjie Zhao ◽  
Martin Irmler ◽  
Xinyu Liu ◽  
Miriam Hoene ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

scholarly journals Hyperglucagonemia correlates with plasma levels of non-branched-chain amino acids in patients with liver disease independent of type 2 diabetes

2018 ◽  
Vol 314 (1) ◽  
pp. G91-G96 ◽  
Author(s):  
Nicolai J. Wewer Albrechtsen ◽  
Anders E. Junker ◽  
Mette Christensen ◽  
Sofie Hædersdal ◽  
Flemming Wibrand ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Amino Acids ◽  
Liver Disease ◽  
Amino Acid ◽  
Plasma Levels ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Elevated Plasma ◽  
Total Amino Acids

Patients with type 2 diabetes (T2D) and patients with nonalcoholic fatty liver disease (NAFLD) frequently exhibit elevated plasma concentrations of glucagon (hyperglucagonemia). Hyperglucagonemia and α-cell hyperplasia may result from elevated levels of plasma amino acids when glucagon’s action on hepatic amino acid metabolism is disrupted. We therefore measured plasma levels of glucagon and individual amino acids in patients with and without biopsy-verified NAFLD and with and without type T2D. Fasting levels of amino acids and glucagon in plasma were measured, using validated ELISAs and high-performance liquid chromatography, in obese, middle-aged individuals with I) normal glucose tolerance (NGT) and NAFLD, II) T2D and NAFLD, III) T2D without liver disease, and IV) NGT and no liver disease. Elevated levels of total amino acids were observed in participants with NAFLD and NGT compared with NGT controls (1,310 ± 235 µM vs. 937 ± 281 µM, P = 0.03) and in T2D and NAFLD compared with T2D without liver disease (1,354 ± 329 µM vs. 511 ± 235 µM, P < 0.0001). Particularly amino acids with known glucagonotropic effects (e.g., glutamine) were increased. Plasma levels of total amino acids correlated to plasma levels of glucagon also when adjusting for body mass index (BMI), glycated hemoglobin (HbA1c), and cholesterol levels (β = 0.013 ± 0.007, P = 0.024). Elevated plasma levels of total amino acids associate with hyperglucagonemia in NAFLD patients independently of glycemic control, BMI or cholesterol - supporting the potential importance of a “liver-α-cell axis” in which glucagon regulates hepatic amino acid metabolism. Fasting hyperglucagonemia as seen in T2D may therefore represent impaired hepatic glucagon action with increasing amino acids levels. NEW & NOTEWORTHY Hypersecretion of glucagon (hyperglucagonemia) has been suggested to be linked to type 2 diabetes. Here, we show that levels of amino acids correlate with levels of glucagon. Hyperglucagonemia may depend on hepatic steatosis rather than type 2 diabetes.

Sign in / Sign up

Export Citation Format

Share Document