Reversible stimuli-responsive controlled release using mesoporous silica nanoparticles functionalized with a smart DNA molecule-gated switch

2012 ◽  
Vol 22 (29) ◽  
pp. 14715 ◽  
Author(s):  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Mian Chen ◽  
Jie Cao ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Dna Molecule

Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles

2015 ◽  
Vol 44 (9) ◽  
pp. 4355-4361 ◽  
Author(s):  
Yu Xiao ◽  
Tao Wang ◽  
Yu Cao ◽  
Xue Wang ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Release System ◽  
Controlled Release System

This work demonstrated the development of a novel controlled release system, which is sensitive to enzyme and voltage stimuli, based on mesoporous silica nanoparticles functionalized by a ferrocene moiety with β-cyclodextrin as the nanovalve.

Smart mesoporous silica nanoparticles for controlled-release drug delivery

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Mahdi Karimi ◽  
Hamed Mirshekari ◽  
Masoumeh Aliakbari ◽  
Parham Sahandi-Zangabad ◽  
Michael R. Hamblin
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Capacity ◽  
Bioactive Molecules ◽  
Stimuli Responsive ◽  
Release Drug ◽  
Stimulus Responsive ◽  
External Stimuli

AbstractStimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular “gatekeepers” or “nanovalves.” In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH, while external stimuli include light, ultrasound, and magnetic fields, and temperature can either be internal or external.

Temperature and ultrasound sensitive gatekeepers for the controlled release of chemotherapeutic drugs from mesoporous silica nanoparticles

2018 ◽  
Vol 6 (3) ◽  
pp. 428-439 ◽  
Author(s):  
T. S. Anirudhan ◽  
Anoop S. Nair
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Transdermal Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Chemotherapeutic Drugs ◽  
Stimuli Responsive ◽  
Internal Organs ◽  
Delivery Route

The copolymer chains were grafted onto the mesopores of silica nanoparticles and could act as stimuli responsive ‘smart’ gatekeepers. With the aid of a transdermal delivery route and ultrasound penetration, even malignant sites of internal organs can be set as targets.

scholarly journals Correction: Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles

2015 ◽  
Vol 44 (17) ◽  
pp. 8300-8300 ◽  
Author(s):  
Yu Xiao ◽  
Tao Wang ◽  
Yu Cao ◽  
Xue Wang ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Dalton Trans ◽  
Release System ◽  
Controlled Release System

Correction for ‘Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles’ by Yu Xiao et al., Dalton Trans., 2015, 44, 4355–4361.

scholarly journals Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 527 ◽  
Author(s):  
Sugata Barui ◽  
Valentina Cauda
Keyword(s):  
Controlled Release ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Cancer Therapeutics ◽  
High Loading ◽  
Active Targeting ◽  
Stimuli Responsive

The presence of leaky vasculature and the lack of lymphatic drainage of small structures by the solid tumors formulate nanoparticles as promising delivery vehicles in cancer therapy. In particular, among various nanoparticles, the mesoporous silica nanoparticles (MSN) exhibit numerous outstanding features, including mechanical thermal and chemical stability, huge surface area and ordered porous interior to store different anti-cancer therapeutics with high loading capacity and tunable release mechanisms. Furthermore, one can easily decorate the surface of MSN by attaching ligands for active targeting specifically to the cancer region exploiting overexpressed receptors. The controlled release of drugs to the disease site without any leakage to healthy tissues can be achieved by employing environment responsive gatekeepers for the end-capping of MSN. To achieve precise cancer chemotherapy, the most desired delivery system should possess high loading efficiency, site-specificity and capacity of controlled release. In this review we will focus on multimodal decorations of MSN, which is the most demanding ongoing approach related to MSN application in cancer therapy. Herein, we will report about the recently tried efforts for multimodal modifications of MSN, exploiting both the active targeting and stimuli responsive behavior simultaneously, along with individual targeted delivery and stimuli responsive cancer therapy using MSN.

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

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