Surface decoration of selenium nanoparticles by mushroom polysaccharides–protein complexes to achieve enhanced cellular uptake and antiproliferative activity

2012 ◽  
Vol 22 (19) ◽  
pp. 9602 ◽  
Author(s):  
Hualian Wu ◽  
Xiaoling Li ◽  
Wen Liu ◽  
Tianfeng Chen ◽  
Yinghua Li ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Antiproliferative Activity ◽  
Protein Complexes ◽  
Selenium Nanoparticles ◽  
Surface Decoration

Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles

2011 ◽  
Vol 83 (1) ◽  
pp. 183-187 ◽  
Author(s):  
Jun-Sheng Zheng ◽  
Shan-Yuan Zheng ◽  
Yi-Bo Zhang ◽  
Bo Yu ◽  
Wenjie Zheng ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Cellular Uptake ◽  
Selenium Nanoparticles ◽  
Surface Decoration

Fluorescent Copper(II) Complexes of Asymmetric Bis(Thiosemicarbazone)s: Electrochemistry, Cellular Uptake and Antiproliferative Activity

2021 ◽  
Vol 6 (24) ◽  
pp. 6063-6070
Author(s):  
Deepti U. Kirtani ◽  
Niraj S. Ghatpande ◽  
Komal R. Suryavanshi ◽  
Prasad P. Kulkarni ◽  
Anupa A. Kumbhar
Keyword(s):  
Cellular Uptake ◽  
Antiproliferative Activity

scholarly journals Multifunctional selenium nanoparticles with Galangin-induced HepG2 cell apoptosis through p38 and AKT signalling pathway

2018 ◽  
Vol 5 (11) ◽  
pp. 180509 ◽  
Author(s):  
Yinghua Li ◽  
Min Guo ◽  
Zhengfang Lin ◽  
Mingqi Zhao ◽  
Yu Xia ◽  
...  
Keyword(s):  
Hepg2 Cell ◽  
Cell Apoptosis ◽  
Hepg2 Cells ◽  
Caspase 3 ◽  
Selenium Nanoparticles ◽  
Potential Candidate ◽  
Common Cancer ◽  
Anti Cancer ◽  
Surface Decoration ◽  
Cancer Activity

The morbidity and mortality of hepatocellular carcinoma, the most common cancer, are increasing continuously worldwide. Galangin (Ga) has been demonstrated to possess anti-cancer effect, but the efficacy of Ga was limited by its low permeability and poor solubility. To develop aqueous formulation and improve the anti-cancer activity of Ga, surface decoration of functionalized selenium nanoparticles with Ga (Se@Ga) was synthesized in the present study. The aim of this study was to evaluate the anti-cancer effect of Se@Ga and the mechanism on HepG2 cells. Se@Ga-induced HepG2 cell apoptosis was confirmed by depletion of mitochondrial membrane potential, translocation of phosphatidylserine and caspase-3 activation. Furthermore, Se@Ga enhanced the anti-cancer activity of HepG2 cells through ROS-mediated AKT and p38 signalling pathways. In summary, these results suggest that Se@Ga might be potential candidate chemotherapy for cancer.

Differential effects of amino acid surface decoration on the anticancer efficacy of selenium nanoparticles

2014 ◽  
Vol 43 (4) ◽  
pp. 1854-1861 ◽  
Author(s):  
Yanxian Feng ◽  
Jianyu Su ◽  
Zhennan Zhao ◽  
Wenjie Zheng ◽  
Hualian Wu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Selenium Nanoparticles ◽  
Anticancer Efficacy ◽  
Differential Effects ◽  
Surface Decoration

Preparation and growth‐promoting effect of selenium nanoparticles capped by polysaccharide‐protein complexes on tilapia

2020 ◽  
Vol 101 (2) ◽  
pp. 476-485
Author(s):  
Lirong Ren ◽  
Zhencong Wu ◽  
Ying Ma ◽  
Wenjie Jian ◽  
Hejian Xiong ◽  
...  
Keyword(s):  
Protein Complexes ◽  
Selenium Nanoparticles ◽  
Promoting Effect ◽  
Growth Promoting

Design and Characterization of a Cancer-Targeted Drug Co-Delivery System Composed of Liposomes and Selenium Nanoparticles

2020 ◽  
Vol 20 (9) ◽  
pp. 5295-5304
Author(s):  
Guangshan Xuan ◽  
Min Zhang ◽  
Yang Chen ◽  
Shan Huang ◽  
Imshik Lee
Keyword(s):  
Folic Acid ◽  
Zeta Potential ◽  
Cellular Uptake ◽  
Delivery System ◽  
Mtt Assay ◽  
Hela Cells ◽  
Selenium Nanoparticles ◽  
Spherical Particles ◽  
Anticancer Efficacy ◽  
Targeted Drug

A drug co-delivery system composed of selenium nanoparticles (SeNPs) has attracted increasing interest due to its ability to increase the anticancer efficacy against multidrug-resistant cancer cells. In this study, a cancer-targeted drug co-delivery system combining fluorescein-loaded liposomes and SeNPs was designed and evaluated. The system was developed by coating SeNPs and fluorescein-loaded liposomes with folic acid-chitosan conjugates (FA-CS-SeNPs-Lips). Folic acid-chitosan conjugates (FA-CS) were synthesized by coupling folic acid (FA) with chitosan (CS), and the structure was confirmed by performing Fourier transform spectroscopy (FT-IR) and nuclear magnetic resonance (1H-NMR) spectroscopy. Dynamic light scattering (DLS) measurements and transmission electron microscopy (TEM) were used to evaluate the particle size, Zeta potential, and morphology. The cytotoxicity of SeNPs coated with FA-CS conjugates (FA-CS-SeNPs) toward A549 cells and HeLa cells was examined using the MTT assay. The cancer-targeting ability and drug release behaviors were evaluated in vitro by measuring the cellular uptake of fluorescein and dialysis, respectively. The FA-CS-SeNPs were uniform, spherical particles with a ~50 nm diameter and high positive Zeta potential (+57.7 mV). Based on the results of the MTT assay, FA-CS-SeNPs displayed a more significant increase in the anticancer efficacy in HeLa cells than CS-SeNPs. FA-CS-SeNPs-Lips not only slowly released fluorescein but also specifically targeted HeLa cells through selective binding between folate and folate receptors to increase the cellular uptake of fluorescein.

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