High efficiency and low toxicity of polyethyleneimine modified Pluronics (PEI–Pluronic) as gene delivery carriers in cell culture and dystrophic mdx mice

2012 ◽  
Vol 22 (13) ◽  
pp. 6038 ◽  
Author(s):  
Mingxing Wang ◽  
Peijuan Lu ◽  
Bo Wu ◽  
Jay D. Tucker ◽  
Caryn Cloer ◽  
...  
Keyword(s):  
Cell Culture ◽  
Gene Delivery ◽  
High Efficiency ◽  
Mdx Mice ◽  
Low Toxicity

Tris[2-(acryloyloxy)ethyl]isocyanurate Cross-Linked Low-Molecular-Weight Polyethylenimine as Gene Delivery Carriers in Cell Culture and Dystrophic mdx Mice

2012 ◽  
Vol 23 (4) ◽  
pp. 837-845 ◽  
Author(s):  
Mingxing Wang ◽  
Jay D. Tucker ◽  
Peijuan Lu ◽  
Bo Wu ◽  
Caryn Cloer ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Cell Culture ◽  
Gene Delivery ◽  
Mdx Mice ◽  
Low Molecular Weight

Recent advances in the analysis full/empty capsid ratio and genome integrity of adeno-associated virus (AAV) gene delivery vectors

2020 ◽  
Vol 20 ◽  
Author(s):  
L. Hajba ◽  
A. Guttman
Keyword(s):  
Gene Delivery ◽  
High Efficiency ◽  
Analytical Techniques ◽  
Viral Gene ◽  
Adeno Associated Virus ◽  
Gene Delivery Vectors ◽  
Empty Capsid ◽  
Purification Methods ◽  
Viral Gene Delivery

: Adeno-associated virus (AAV) is one of the most promising viral gene delivery vectors with long-term gene expression and disease correction featuring high efficiency and excellent safety in human clinical trials. During the production of AAV vectors,there are several quality control (QC)parameters that should be rigorously monitored to comply with clini-cal safety and efficacy. This review gives a short summary of the most frequently used AVV production and purification methods,focusing on the analytical techniques applied to determine the full/empty capsid ratio and the integrity of the encapsidated therapeutic DNA of the products.

scholarly journals Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2978
Author(s):  
Chia-Jung Li ◽  
Yen-Dun Tony Tzeng ◽  
Yi-Han Chiu ◽  
Hung-Yu Lin ◽  
Ming-Feng Hou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
High Efficiency ◽  
Early Recurrence ◽  
New Developments ◽  
Great Progress ◽  
Low Toxicity ◽  
Made In

Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies.

High efficiency lentiviral gene delivery in non-dividing cells by deoxynucleoside treatment

2002 ◽  
Vol 4 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Elisabetta Ravot ◽  
Giuditta Comolli ◽  
Franco Lori ◽  
Julianna Lisziewicz
Keyword(s):  
Gene Delivery ◽  
High Efficiency ◽  
Dividing Cells

Polyethylenimine-grafted polyamidoamine conjugates for gene delivery with high efficiency and low cytotoxicity

2014 ◽  
Vol 22 (7) ◽  
pp. 757-764 ◽  
Author(s):  
Tae-Hun Kim ◽  
Ho Won Seo ◽  
Jin Han ◽  
Kyung Soo Ko ◽  
Joon Sig Choi
Keyword(s):  
Gene Delivery ◽  
High Efficiency ◽  
Low Cytotoxicity

Layer-by-Layer Biomimetic Microgels for 3D Cell Culture and Nonviral Gene Delivery

2021 ◽  
Author(s):  
Bruna G. Carvalho ◽  
Franciele F. Vit ◽  
Hernandes F. Carvalho ◽  
Sang W. Han ◽  
Lucimara G. de la Torre
Keyword(s):  
Cell Culture ◽  
Gene Delivery ◽  
3D Cell Culture ◽  
Nonviral Gene Delivery ◽  
Layer By Layer

Facile synthesis of GalNAc monomers and block polycations for hepatocyte gene delivery

2021 ◽  
Author(s):  
Matthew R. Bockman ◽  
Rishad J. Dalal ◽  
Ramya Kumar ◽  
Theresa M. Reineke
Keyword(s):  
Gene Delivery ◽  
Synthetic Route ◽  
Facile Synthesis ◽  
Low Toxicity ◽  
Delivery Vehicles

Here, we present a facile synthetic route for a monomer displaying N-acetyl-d-galactosamine and subsequent copolymerization in a block format with cationic subunits readily accessing liver-targeted polymeric pDNA delivery vehicles with low toxicity.

scholarly journals High-efficiency endovascular gene delivery via therapeutic ultrasound

2001 ◽  
Vol 37 (7) ◽  
pp. 1975-1980 ◽  
Author(s):  
Philippe G Amabile ◽  
Jacob M Waugh ◽  
Thomas N Lewis ◽  
Christopher J Elkins ◽  
Wolfgang Janas ◽  
...  
Keyword(s):  
Gene Delivery ◽  
High Efficiency ◽  
Therapeutic Ultrasound
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