Microscale fluid flow analysis in a human osteocyte canaliculus using a realistic high-resolution image-based three-dimensional model

2012 ◽  
Vol 4 (10) ◽  
pp. 1198-1206 ◽  
Author(s):  
Hiroshi Kamioka ◽  
Yoshitaka Kameo ◽  
Yuichi Imai ◽  
Astrid D. Bakker ◽  
Rommel G. Bacabac ◽  
...  
Author(s):  
Ersin Sayar ◽  
Bakhtier Farouk

Coupled structural and fluid flow analysis of a piezoelectric valveless micropump is carried out for liquid transport applications. The valveless micropump consists of trapezoidal prism inlet/outlet elements; the pump chamber, a thin structural layer (Pyrex glass) and a piezoelectric element (PZT-5A), as the actuator. Two-way coupling of forces and displacements between the solid and the liquid domains in the systems are considered where actuator deflection and motion causes fluid flow and vice-versa. Flow contraction and expansion (through the trapezoidal prism inlet and outlet respectively) generates net fluid flow. The pressure, velocity, flow rate and pump membrane deflections of the micropump are investigated for six different working fluids (acetone, methanol, ethanol, water, and two hypothetical fluids). For the compressible flow formulation, an isothermal equation of state for the working fluid is employed. Three-dimensional governing equations for the flow fields and the structural-piezoelectric bi-layer membrane motions are considered. Comparison of the pumping characteristics of the micropumps operating with different working fluids can be utilized to optimize the design of MEMS based micropumps in drug delivery and biomedical applications.


2005 ◽  
Vol 38 (3) ◽  
pp. 563-565 ◽  
Author(s):  
Filipe R. N. C. Maia ◽  
Abraham Szöke ◽  
Warren DeLano ◽  
David van der Spoel

A new tool has been developed to aid in the visualization of electron density in crystals or from quantum chemistry calculations. It displays the fine details of the electron density on a plane and the three-dimensional model of the molecule at the same time. The program enables the user to examine the details of weak or irregular features. Such features frequently occur in low-resolution maps, where they determine the correct tracing of a protein backbone. In high-resolution maps, solvent regions are difficult or impossible to observe using isosurfaces. The tool has been integrated into an existing molecular visualization package (PyMol) making it possible to observe and interact both with a structure model and the electron density slices freely, simultaneously and independently. This visualization model fills a gap in the visualization methods available to crystallographers and others who work with electron density maps.


2020 ◽  
Vol 61 (2) ◽  
pp. 1-9
Author(s):  
Ha Viet Nhu ◽  

In this study, the approaches and research methods have been proposed based on the analysis of challenges in modeling, establishing a three-dimensional model of geological engineering conditions of the Hanoi area. The three-dimensional model of the Hanoi area was composed of 21 geological engineering units as a stacked structure, with accuracy and reliability were verified by statistical evaluation. Based on the integration of engineering geological attributes, the model has contributed for reconstruction of the geospatial engineering geological structure of the study area as comprehensive, continuously, and high resolution.


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