Boletus edulis biologically active biopolymers induce cell cycle arrest in human colon adenocarcinoma cells

2013 ◽  
Vol 4 (4) ◽  
pp. 575 ◽  
Author(s):  
Marta Kinga Lemieszek ◽  
Claudia Cardoso ◽  
Fernando Hermínio Ferreira Milheiro Nunes ◽  
Ana Isabel Ramos Novo Amorim de Barros ◽  
Guilhermina Marques ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Colon Adenocarcinoma ◽  
Human Colon ◽  
Biologically Active ◽  
Induce Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Adenocarcinoma Cells ◽  
Human Colon Adenocarcinoma ◽  
Colon Adenocarcinoma Cells

Widdrol induces cell cycle arrest, associated with MCM down-regulation, in human colon adenocarcinoma cells

2010 ◽  
Vol 290 (1) ◽  
pp. 96-103 ◽  
Author(s):  
Hyun Ju Kwon ◽  
Yun Kyung Hong ◽  
Cheol Park ◽  
Yung Hyun Choi ◽  
Hee Jung Yun ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Colon Adenocarcinoma ◽  
Human Colon ◽  
Down Regulation ◽  
Cycle Arrest ◽  
Adenocarcinoma Cells ◽  
Human Colon Adenocarcinoma ◽  
Colon Adenocarcinoma Cells

scholarly journals Pharmacokinetic, Antiproliferative and Apoptotic Effects of Phenolic Acids in Human Colon Adenocarcinoma Cells Using In Vitro and In Silico Approaches

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2569 ◽  
Author(s):  
Lana Rosa ◽  
Nathállia Jordão ◽  
Nathália da Costa Pereira Soares ◽  
Joelma deMesquita ◽  
Mariana Monteiro ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Viability ◽  
Colon Adenocarcinoma ◽  
Human Colon ◽  
G1 Phase ◽  
Apoptotic Cells ◽  
Adenocarcinoma Cells ◽  
Human Colon Adenocarcinoma ◽  
Colon Adenocarcinoma Cells

Colon cancer is the second most common cause of cancer deaths in the USA and Europe. Despite aggressive therapies, many tumors are resistant to current treatment protocols and epidemiological data suggest that diet is a major factor in the etiology of colon cancer. This study aimed to evaluate the antioxidant activity and the influence of 3,4-dihydroxyphenylacetic (3,4-DHPAA), p-coumaric (p-CoA), vanillic (VA) and ferulic (FA) acids on cell viability, cell cycle progression, and rate of apoptosis in human colon adenocarcinoma cells (HT-29). The results showed that all compounds tested reduce cell viability in human colon cancer cells. 3,4-DHPAA promoted the highest effect antiproliferative with an increase in the percentage of cells in G0/G1 phase, accompanied by a reduction of cells in G2/M phase. Cell cycle analysis of VA and FA showed a decrease in the proportion of cells in G0/G1 phase (10.0 µM and 100.0 µM). p-CoA and FA acids increased the percentage of apoptotic cells and non-apoptotic cells. 3,4-DHPAA seems to be the substance with the greatest potential for in vivo studies, opening thus a series of perspectives on the use of these compounds in the prevention and treatment of colon cancer.

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