Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase

2012 ◽  
Vol 41 (21) ◽  
pp. 6468 ◽  
Author(s):  
Bruno Demoro ◽  
Francesco Caruso ◽  
Miriam Rossi ◽  
Diego Benítez ◽  
Mercedes González ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Metal Complexes ◽  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase ◽  
Selective Inhibitors

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design

2005 ◽  
Vol 62 (1) ◽  
pp. 80-88 ◽  
Author(s):  
Sandra B. Gabelli ◽  
Jason S. McLellan ◽  
Andrea Montalvetti ◽  
Eric Oldfield ◽  
Roberto Docampo ◽  
...  
Keyword(s):  
Drug Design ◽  
Trypanosoma Cruzi ◽  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase

scholarly journals Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase

2012 ◽  
Vol 55 (14) ◽  
pp. 6445-6454 ◽  
Author(s):  
Srinivas Aripirala ◽  
Sergio H. Szajnman ◽  
Jean Jakoncic ◽  
Juan B. Rodriguez ◽  
Roberto Docampo ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Crystallographic Analysis ◽  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase ◽  
Design Synthesis

scholarly journals Farnesyl diphosphate synthase localizes to the cytoplasm of Trypanosoma cruzi and T. brucei

2008 ◽  
Vol 119 (2) ◽  
pp. 308-312 ◽  
Author(s):  
Marcela Ferella ◽  
Zhu-Hong Li ◽  
Björn Andersson ◽  
Roberto Docampo
Keyword(s):  
Trypanosoma Cruzi ◽  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase

scholarly journals Inhibitors of Leishmania Major Farnesyl Diphosphate Synthase: Crystallographic and Calorimetric Studies

2011 ◽  
Vol 100 (3) ◽  
pp. 218a-219a
Author(s):  
Srinivas Aripirala ◽  
Sandra Gabelli ◽  
Eric Oldfield ◽  
Dolores Gonzalez Pacanowska ◽  
Mario Amzel
Keyword(s):  
Leishmania Major ◽  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase ◽  
Calorimetric Studies
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