scholarly journals Hyperspectral darkfield microscopy of single hollow gold nanoparticles for biomedical applications

2013 ◽  
Vol 15 (12) ◽  
pp. 4163-4168 ◽  
Author(s):  
Natasha Fairbairn ◽  
Agathi Christofidou ◽  
Antonios G. Kanaras ◽  
Tracey A. Newman ◽  
Otto L. Muskens
Keyword(s):  
Gold Nanoparticles ◽  
Biomedical Applications ◽  
Hollow Gold Nanoparticles ◽  
Darkfield Microscopy

scholarly journals Phosphatidylserine-Gold Nanoparticles (PS-AuNP) Induce Prostate and Breast Cancer Cell Apoptosis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1094
Author(s):  
Allan Radaic ◽  
Nam E. Joo ◽  
Soo-Hwan Jeong ◽  
Seong-II Yoo ◽  
Nicholas Kotov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Biomedical Applications ◽  
Therapeutic Potential ◽  
Control Treatment ◽  
Track Record ◽  
Males And Females ◽  
Breast And Prostate Cancer ◽  
First Time

Prostate and breast cancer are the current leading causes of new cancer cases in males and females, respectively. Phosphatidylserine (PS) is an essential lipid that mediates macrophage efferocytosis and is dysregulated in tumors. Therefore, developing therapies that selectively restore PS may be a potential therapeutic approach for carcinogenesis. Among the nanomedicine strategies for delivering PS, biocompatible gold nanoparticles (AuNPs) have an extensive track record in biomedical applications. In this study, we synthesized biomimetic phosphatidylserine-caped gold nanoparticles (PS-AuNPs) and tested their anticancer potential in breast and prostate cancer cells in vitro. We found that both cell lines exhibited changes in cell morphology indicative of apoptosis. After evaluating for histone-associated DNA fragments, a hallmark of apoptosis, we found significant increases in DNA fragmentation upon PS-AuNP treatment compared to the control treatment. These findings demonstrate the use of phosphatidylserine coupled with gold nanoparticles as a potential treatment for prostate and breast cancer. To the best of our knowledge, this is the first time that a phosphatidylserine-capped AuNP has been examined for its therapeutic potential in cancer therapy.

scholarly journals Molecular detection using aptamer-modified gold nanoparticles with an immobilized DNA brush for the prevention of non-specific aggregation

RSC Advances ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 11984-11991
Author(s):  
Yuki Yano-Ozawa ◽  
Nadine Lobsiger ◽  
Yu Muto ◽  
Takahiro Mori ◽  
Ken Yoshimura ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Molecular Detection ◽  
Darkfield Microscopy

We demonstrated molecular detection using aptamer-modified gold nanoparticles with DNA-brush for the prevention of non-specific aggregation and smartphone darkfield microscopy.

scholarly journals Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 844 ◽  
Author(s):  
Andrea Rónavári ◽  
Nóra Igaz ◽  
Dóra I. Adamecz ◽  
Bettina Szerencsés ◽  
Csaba Molnar ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Biomedical Applications ◽  
Biological Activities ◽  
Large Body ◽  
Chemical Properties ◽  
Biological Synthesis ◽  
Silver And Gold Nanoparticles ◽  
Comprehensive Collection ◽  
Synthetic Approaches ◽  
Physical And Chemical

The nanomaterial industry generates gigantic quantities of metal-based nanomaterials for various technological and biomedical applications; however, concomitantly, it places a massive burden on the environment by utilizing toxic chemicals for the production process and leaving hazardous waste materials behind. Moreover, the employed, often unpleasant chemicals can affect the biocompatibility of the generated particles and severely restrict their application possibilities. On these grounds, green synthetic approaches have emerged, offering eco-friendly, sustainable, nature-derived alternative production methods, thus attenuating the ecological footprint of the nanomaterial industry. In the last decade, a plethora of biological materials has been tested to probe their suitability for nanomaterial synthesis. Although most of these approaches were successful, a large body of evidence indicates that the green material or entity used for the production would substantially define the physical and chemical properties and as a consequence, the biological activities of the obtained nanomaterials. The present review provides a comprehensive collection of the most recent green methodologies, surveys the major nanoparticle characterization techniques and screens the effects triggered by the obtained nanomaterials in various living systems to give an impression on the biomedical potential of green synthesized silver and gold nanoparticles.

Green and facile preparation and dual-enhancement cytotoxicity of eupatilin loaded on hollow gold nanoparticles under near-infrared light

2021 ◽  
Author(s):  
Yi-wei Sun ◽  
Hui Liang ◽  
Kun-qi Zong ◽  
Xin Che ◽  
Da-li Meng
Keyword(s):  
Gold Nanoparticles ◽  
Natural Products ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Hollow Gold Nanoparticles ◽  
Facile Preparation ◽  
Gold Nanomaterials ◽  
Anti Tumor Activity ◽  
Targeted Release

Using NIR irradiation, gold nanomaterials loaded with natural products can achieve targeted release as well as better anti-tumor activity.

Hyperthermic Cytotoxicity Induced by Noninvasive Radiofrequency Field Exposure After Delivery of EGFR Family Targeted Gold Nanoparticles

2010 ◽  
Author(s):  
Evan S. Glazer ◽  
Warna D. Kaluarachchi ◽  
Steven A. Curley
Keyword(s):  
Flow Cytometry ◽  
Gold Nanoparticles ◽  
Metal Nanoparticles ◽  
Biomedical Applications ◽  
Carcinoma Cells ◽  
Field Exposure ◽  
Radiofrequency Field ◽  
Hep3b Cells ◽  
Egfr Family ◽  
Similar Decrease

Noninvasive radiofrequency (RF) fields heat metal nanoparticles in a concentration dependent fashion. Gold nanoparticles are especially interesting for biomedical applications because they not only heat well, but they have an established biosafety profile. Antibody-targeted gold nanoparticles have been used to induce hyperthermic cytotoxicity when exposed to RF fields. Two carcinoma cells lines, Panc-1 and Hep3B, were individually treated with 100 nM panitumumab and trastuzumab antibody conjugated 10 nm gold nanoparticles and subsequently exposed to an RF field for a total generator power of ∼100 kJ. Two days later, control cells treated with antibody labeled gold nanoparticles, but not exposed to the RF field, maintained an average viability of 92.1% ± 2.5% for Hep 3B cells and 89.1% ± 2.1% for Panc-1 cells based on flow cytometry. Panc-1 cells treated the same way with subsequent RF field exposure had viability less than 80% (p ∼ 0.001). Hep3B cells showed a similar decrease in viability after trastuzumab-gold treatment (74.5% ± 6.9%), but not panitumumab. This demonstrates a new and developing use of antibodies, specifically, against EGFR family targets.

Nanogold-based materials in medicine: from their origins to their future

Nanomedicine ◽  
2021 ◽  
Author(s):  
Tânia Ferreira-Gonçalves ◽  
David Ferreira ◽  
Hugo A Ferreira ◽  
Catarina P Reis
Keyword(s):  
Gold Nanoparticles ◽  
Optical Properties ◽  
Potential Application ◽  
Biomedical Applications ◽  
Production Method ◽  
Therapeutic Approaches ◽  
Production Methods ◽  
Research Fields

The properties of gold-based materials have been explored for centuries in several research fields, including medicine. Multiple published production methods for gold nanoparticles (AuNPs) have shown that the physicochemical and optical properties of AuNPs depend on the production method used. These different AuNP properties have allowed exploration of their usefulness in countless distinct biomedical applications over the last few years. Here we present an extensive overview of the most commonly used AuNP production methods, the resulting distinct properties of the AuNPs and the potential application of these AuNPs in diagnostic and therapeutic approaches in biomedicine.

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