Deducing primary nucleation parameters from metastable zone width and induction time data determined with simulation

CrystEngComm ◽  
2013 ◽  
Vol 15 (6) ◽  
pp. 1199-1209 ◽  
Author(s):  
M. Kobari ◽  
N. Kubota ◽  
I. Hirasawa
Keyword(s):  
Induction Time ◽  
Time Data ◽  
Metastable Zone Width ◽  
Zone Width ◽  
Nucleation Parameters ◽  
Primary Nucleation ◽  
Metastable Zone

scholarly journals Comparison of the Nucleation Parameters of Aqueous L-glycine Solutions in the Presence of L-arginine from Induction Time and Metastable-Zone-Width Data

Crystals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1226
Author(s):  
Lie-Ding Shiau
Keyword(s):  
Free Energy ◽  
Induction Time ◽  
Impurity Concentration ◽  
Lag Time ◽  
Interfacial Free Energy ◽  
Time Data ◽  
Metastable Zone Width ◽  
Zone Width ◽  
Nucleation Parameters ◽  
Metastable Zone

Induction time and metastable-zone-width (MSZW) data for aqueous L-glycine solutions in the presence of L-arginine impurity were experimentally measured using a turbidity probe in this study. The nucleation parameters, including the interfacial free energy and pre-exponential nucleation factor, obtained from induction time data, were compared with those obtained from MSZW data. The influences of lag time on the nucleation parameters were examined for the induction time data. The effects of L-arginine impurity concentration on the nucleation parameters based on both the induction time and MSZW data were investigated in detail.

A model for determination of the interfacial energy from the induction time or metastable zone width data based on turbidity measurements

CrystEngComm ◽  
2014 ◽  
Vol 16 (41) ◽  
pp. 9743-9752 ◽  
Author(s):  
Lie-Ding Shiau ◽  
Tsan-Sheng Lu
Keyword(s):  
Interfacial Energy ◽  
Induction Time ◽  
Metastable Zone Width ◽  
Zone Width ◽  
Metastable Zone

A model is developed to recover the interfacial energy from the induction time and the metastable zone width data.

Crystallization of Pentaerythritol I. Solubility, Density and Metastable Zone Width

1994 ◽  
Vol 59 (6) ◽  
pp. 1261-1269 ◽  
Author(s):  
Miloslav Karel ◽  
Jaroslav Nývlt ◽  
Angelo Chianese
Keyword(s):  
Aqueous Solutions ◽  
Nucleation Rate ◽  
Laboratory Experiments ◽  
Metastable Zone Width ◽  
Zone Width ◽  
Kinetics Of Crystallization ◽  
Primary Nucleation ◽  
Metastable Zone ◽  
Width Measurements ◽  
Kinetics Of

Solubility of pentaerythritol in water has been determined using literature data, the polythermal method and the dry residue method. Densities of its aqueous solutions have been measured using a pycnometer. Kinetics of crystallization of the pentaerythritol has been determined in laboratory experiments. In this paper, metastable zone width measurements have been employed for the assessment of the primary nucleation rate.

scholarly journals The Metastability and Nucleation Thresholds of Ibuprofen in Ethanol and Water-Ethanol Mixtures

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Abdur Rashid ◽  
Edward T. White ◽  
Tony Howes ◽  
James D. Litster ◽  
Ivan Marziano
Keyword(s):  
Water Content ◽  
Propanoic Acid ◽  
Secondary Nucleation ◽  
Metastable Zone Width ◽  
Zone Width ◽  
Primary Nucleation ◽  
Metastable Zone ◽  
The Times ◽  
Induction Times ◽  
Supersaturated Solutions

To investigate the crystallization of ibuprofen [((RS)-2-(4-(2-methylpropyl) phenyl) propanoic acid)] from ethanol and water-ethanol mixtures it is necessary to know the nucleation limits of its solutions. In the absence of crystals, nucleation will seldom occur below the PNT (primary nucleation threshold). If crystals are present, nucleation will seldom occur until below the lower SNT (secondary nucleation threshold). Below the SNT, crystals will still grow with negligible nucleation. PNT and SNT values (expressed as relative supersaturationσ) have been measured at 10, 25, and 40°C for ibuprofen in ethanol and in a range of mixtures of different ethanol (E)/water (W) ratios. The induction times were determined from observing the times to nucleate for a range of different supersaturated solutions at a given temperature andE/Wratio. As expected, lowering the supersaturation leads to longer induction times. In ethanol, the SNT values are small and thus the secondary metastable zone width (MSZW) is relatively narrow with a 1 h SNT relative supersaturation typically aboutσ~ 0.05. The 1 h PNT values are much larger with values forσaround 0.3. In aqueous ethanolic mixtures at 25°C, both the PNT and SNT decrease as the water content increases.

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