Distinguishing between polymorphic forms of linezolid by solid-phase electronic and vibrational circular dichroism

2012 ◽  
Vol 48 (43) ◽  
pp. 5295 ◽  
Author(s):  
Jadwiga Frelek ◽  
Marcin Górecki ◽  
Marta Łaszcz ◽  
Agata Suszczyńska ◽  
Elemér Vass ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Solid Phase ◽  
Vibrational Circular Dichroism ◽  
Polymorphic Forms ◽  
Circular Dichroïsm

scholarly journals Solid Phase Nitrosylation of Enantiomeric Cobalt(II) Complexes

Chemistry ◽  
2021 ◽  
Vol 3 (2) ◽  
pp. 585-597
Author(s):  
Mads Sondrup Møller ◽  
Morten Czochara Liljedahl ◽  
Vickie McKee ◽  
Christine J. McKenzie
Keyword(s):  
Circular Dichroism ◽  
Solid State ◽  
Atmospheric Pressure ◽  
Solid Phase ◽  
Cobalt Complexes ◽  
Vibrational Circular Dichroism ◽  
Chiral Induction ◽  
Solution State ◽  
Circular Dichroïsm ◽  
Salen Ligand

Accompanied by a change in color from red to black, the enantiomorphic phases of the cobalt complexes of a chiral salen ligand (L2−, Co(L)·CS2, and Co(L) (L = LS,S or LR,R)) chemisorb NO (g) at atmospheric pressure and rt over hours for the CS2 solvated phase, and within seconds for the desolvated phase. NO is installed as an axial nitrosyl ligand. Aligned but unconnected voids in the CS2 desorbed Co(LR,R)·CS2 structure indicate conduits for the directional desorption of CS2 and reversible sorption of NO, which occur without loss of crystallinity. Vibrational circular dichroism (VCD) spectra have been recorded for both hands of LH2, Zn(L), Co(L)·CS2, Co(L), Co(NO)(L), and Co(NO)(L)·CS2, revealing significant differences between the solution-state and solid-state spectra. Chiral induction enables the detection of the νNO band in both condensed states, and surprisingly also the achiral lattice solvent (CS2 (νCS at 1514 cm−1)) in the solid-state VCD. Solution-state spectra of the paramagnetic Co(II) complex shows a nearly 10-fold enhancement and more extensive inversion of polarity of the vibrations of dominant VCD bands compared to the spectra of the diamagnetic compounds. This enhancement is less pronounced when there are fewer polarity inversions in the solid state VCD spectra.

A vibrational circular dichroism (VCD) methodology for the measurement of enantiomeric excess in chiral compounds in the solid phase and for the complementary use of NMR and VCD techniques in solution: the camphor case

The Analyst ◽  
2018 ◽  
Vol 143 (6) ◽  
pp. 1406-1416 ◽  
Author(s):  
María Mar Quesada-Moreno ◽  
Albert Virgili ◽  
Eva Monteagudo ◽  
Rosa M. Claramunt ◽  
Juan Ramón Avilés-Moreno ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Solid Phase ◽  
Enantiomeric Excess ◽  
Vibrational Circular Dichroism ◽  
Solid Samples ◽  
Chiral Compounds ◽  
First Time ◽  
Circular Dichroïsm

For the first time, it is shown that VCD spectroscopy can be used to determine the % ee in chiral solid samples.

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