A novel approach for the direct determination of residual template molecules in molecularly imprinted polymer matrices

2012 ◽  
Vol 4 (9) ◽  
pp. 2755 ◽  
Author(s):  
Florian Meier ◽  
Sven M. Elbert ◽  
Boris Mizaikoff
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Direct Determination ◽  
Polymer Matrices ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Novel Approach

scholarly journals Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues

2013 ◽  
Vol 63 (2) ◽  
pp. 265-275 ◽  
Author(s):  
Rym Lahsini ◽  
Mohamed R. Louhaichi ◽  
Nafaa Adhoum ◽  
Lotfi Monser
Keyword(s):  
Molecularly Imprinted Polymer ◽  
High Performance ◽  
Solid Phase ◽  
Industrial Process ◽  
Direct Determination ◽  
Dimethyl Formamide ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Recovery Percentage

The performance of a molecularly imprinted polymer (MIP) as selective packing material for solid-phase extraction (SPE) of residual glibenclamide in an industrial process was investigated. MIP was prepared using 4-vinylpyridine as monomer, ethylenedimethacrylate as cross linker, 2,2’-azobis-2-methylpropionitrile as initiator and dimethyl formamide as porogen. Use of acetonitrile as a rebinding solvent allows good recognition of the glibenclamide template. It was found that this polymer can be used for determination of trace levels of glibenclamide with a recovery percentage that could reach 87.1 %. Furthermore, the synthesized MIP showed higher selectivity towards glibenclamide than other compounds such as glimepiride and metformine. The synthesized MIP enabled direct determination of the target contaminant after an enrichment step that allowed quantification of glibenclamide at a concentration as low as 0.016 mg L-1. Combination of high performance liquid chromatography with MIP-SPE could be successfully used for quality control of pharmaceuticals during the cleaning process in the production of dry drug forms.

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