A spirooxazine derivative as a highly sensitive cyanide sensor by means of UV-visible difference spectroscopy

The Analyst ◽  
2012 ◽  
Vol 137 (23) ◽  
pp. 5581 ◽  
Author(s):  
Shaoyin Zhu ◽  
Minjie Li ◽  
Lan Sheng ◽  
Peng Chen ◽  
Yumo Zhang ◽  
...  
Keyword(s):  
Difference Spectroscopy ◽  
Highly Sensitive ◽  
Uv Visible

A benzo[e]indole[2,1-b][1,3]benzooxazine derivative as a highly sensitive CN− sensor by means of UV–visible difference spectroscopy

2021 ◽  
Vol 189 ◽  
pp. 109252
Author(s):  
Yan Zhu ◽  
Guo-Guo Chen ◽  
Zhen-You Zhang ◽  
Shi-Li Shen ◽  
Yan-Qing Ge ◽  
...  
Keyword(s):  
Difference Spectroscopy ◽  
Highly Sensitive ◽  
Uv Visible

scholarly journals UV SPECTROPHOTOMETRIC ANALYSIS AND VALIDATION OF OSELTAMIVIRPHOSPHATE IN PURE AND PHARMACEUTICAL FORMULATION

2020 ◽  
pp. 111-114 ◽  
Author(s):  
SACHIN A. YANJANE ◽  
SHRISHAIL M. GHURGHURE ◽  
VINOD K. MATOLE
Keyword(s):  
Spectrophotometric Method ◽  
Spectrophotometric Analysis ◽  
Pharmaceutical Formulation ◽  
Ich Guidelines ◽  
Highly Sensitive ◽  
Double Beam ◽  
Recovery Study ◽  
Uv Visible ◽  
Oseltamivir Phosphate ◽  
Simple Economic

Objective: A new, simple, economical, precise, sensitive, linear, accurate, rapid UV spectrophotometric method has been developed for the estimation of Oseltamivir Phosphate in pure form and pharmaceutical formulation. Methods: This UV method was developed using Methanol as a solvent. In the present method, the wavelength selected for analysis was 218 nm. UV-Visible double beam spectrophotometer (Systronic 2201) was used to carry out spectral analysis. The ICH guidelines were used to validate the method. Results: The method was validated for linearity, range, accuracy, precision, robustness, LOD and LOQ. Linearity was found in the range of 10-50µg/ml. Accuracy was performed by using a recovery study. The amount of drug recovered was found to be in the range of 99.01-100.1%. The % RSD value was found to be less than 2. Conclusion: The developed UV spectrophotometric method was found to be simple, economic, sensitive, easy, accurate, linear, specific and highly sensitive and can be used for routine estimation of Oseltamivir Phosphate.

scholarly journals Area Under Curve by UV Spectrophotometric Method for Determination Albendazole in Bulk

2019 ◽  
Vol 9 (6) ◽  
pp. 47-50
Author(s):  
Kedar Vikas Dagdu ◽  
Manoj Gadhave ◽  
Shubham Bhujbal ◽  
Bhushan Shrinath
Keyword(s):  
Spectrophotometric Method ◽  
Area Under Curve ◽  
Active Pharmaceutical Ingredient ◽  
Control Analysis ◽  
Distilled Water ◽  
Quality Control Analysis ◽  
Ich Guidelines ◽  
Highly Sensitive ◽  
Uv Visible ◽  
Routine Quality Control

The aim of present investigation is to establish simple, precise, and rapid Spectrophotometric method for the quantification of Albendazole in Active Pharmaceutical Ingredient. In this, work is carried out to for estimation of Albendazole bulk by utilizing an Area under Curve (AUC) method using UV – Visible Spectrophotometry. The study is designed to validate the developed methods as per ICH guidelines. For this purpose the wavelength range between 200-400 nm was selected. Methanolic distilled water (50 ml methanol used for stock solution and serial dilution in 25 ml distilled water) was used as a solvent throughout the work. Linearity was obtained in concentration range 2 to 10 ɥg/ml (r2 = 0.992) for the method. The developed method was found to be simple, linear, accurate, precise and highly sensitive and which can be used for routine quality control analysis for Spectrophotometric estimation of Active Pharmaceutical Ingredient. KeywordS: Albendazole, linearity, AUC, spectrophotometer, methanol, distilled water.

scholarly journals Derivatizing Reagents for Detection of Organic Compounds By HPLC

2021 ◽  
pp. 1-13
Author(s):  
Pooja T. Chhanikar ◽  
Krishna R. Gupta ◽  
Milind J. Umekar
Keyword(s):  
Fluorescence Detection ◽  
Sulfonyl Chloride ◽  
Phenyl Isocyanate ◽  
Fluorescent Detection ◽  
Chemical Derivatization ◽  
Or Groups ◽  
Highly Sensitive ◽  
Simple Chemical ◽  
Derivatizing Agent ◽  
Uv Visible

Derivatization is the process of chemically modifying a compound to develope a new compound which has properties that are suitable for analysis using HPLC. Derivatization improves the detectability of a target analyte by reaction with suitable derivatizing agent. Derivatization reactions are simple chemical modification of substance that make it compatible with the selected separation method or transforms substance with a low UV- absorption into highly sensitive product. Derivatization reactions in liquid chromatography modify the solutes adding a chomophore for easy UV detection or a fluorophore for sensitive fluorescent detection. The chemical structure of the compound remains same and just modifies the specific functional group for reacting compounds to derivative of deviating chemical and physical properties in order to make them detectable. Introduction of certain elements or groups through chemical derivatization may enhance the detector’s response helpful for the elucidation of structure of analytes. In conclusion, the present review describe various derivatization reagents for pre-column and post column derivatization process in HPLC by UV-visible and fluorescence detection are summarized along with reactions and some practical aspects. The commonly used derivatizing reagents in HPLC are 1-fluoro-2, 4-dinitrobenzene, ninhydrine, 4-N-N-dimethylaminoazobenzene-4’-sulfonyl chloride, benzoyl chloride, phenyl isocyanate for UV-visible detection and o-phthalaldehyde, fluorescamine, 1-dimethylaminonapthalene-5-sulfonyl chloride (DNS-Cl), 9-fluorenylmethyl chloroformate (Fmoc-Cl), benzofurans for Fluorescence detection.

scholarly journals PAA Modified Upconversion Nanoparticles for Highly Selective and Sensitive Detection of Cu2+ Ions

2021 ◽  
Vol 8 ◽  
Author(s):  
Shaoshan Su ◽  
Zhurong Mo ◽  
Guizhen Tan ◽  
Hongli Wen ◽  
Xiang Chen ◽  
...  
Keyword(s):  
Near Infrared ◽  
Upconversion Emission ◽  
Upconversion Nanoparticles ◽  
Highly Sensitive ◽  
Carboxylate Complex ◽  
Sensitivity And Selectivity ◽  
Uv Visible ◽  
Emission Quenching ◽  
Co Precipitation ◽  
Higher Sensitivity

Detection of the Cu2+ ions is crucial because of its environmental and biological implications. The fluorescent-based organic sensors are not suitable for Cu2+ detection due to their short penetration depth caused by the UV/visible excitation source. Therefore, we have demonstrated a highly sensitive and selective near-infrared (NIR) excitable poly(acrylic acid) (PAA) coated upconversion nanoparticles (UCNPs) based sensor for Cu2+ detection. We construct the PAA modified Na(Yb, Nd)F4@Na(Yb, Gd)F4:Tm@NaGdF4 core-shell-shell structured UCNPs based sensor via a co-precipitation route. The upconversion emission intensity of the PAA-UCNPs decreases linearly with the increase in the Cu2+ concentration from 0.125 to 3.125 μM due to the copper carboxylate complex formation between Cu2+ and PAA-UCNPs. The calculated detection limit of the PAA-UCNPs based sensor is 0.1 μM. The PAA-UCNPs based sensor is very sensitive and selective toward detecting the Cu2+ ions, even when the Cu2+ co-exist with other metal ions. The EDTA addition has significantly reversed the upconversion emission quenching by forming the EDTA-Cu2+ complex based on their greater affinity toward the Cu2+. Therefore, the PAA-UCNPs based sensor can be a promising candidate for Cu2+ detection because of their higher sensitivity and selectivity under 980 nm NIR excitation.

Wafer-size growth of 2D layered SnSe films for UV-Visible-NIR photodetector arrays with high responsitivity

Nanoscale ◽  
2020 ◽  
Vol 12 (13) ◽  
pp. 7358-7365 ◽  
Author(s):  
Lanzhong Hao ◽  
Yongjun Du ◽  
Zegao Wang ◽  
Yupeng Wu ◽  
Hanyang Xu ◽  
...  
Keyword(s):  
Thin Films ◽  
Magnetron Sputtering ◽  
Crystal Quality ◽  
High Responsivity ◽  
High Uniformity ◽  
Highly Sensitive ◽  
Size Growth ◽  
Wafer Size ◽  
Uv Visible ◽  
Photodetector Arrays

Wafer-size SnSe thin films with high uniformity and high crystal quality were grown by magnetron sputtering technique, and exhibit a highly sensitive to a broadband wavelength with high responsivity of 277.3 AW−1 and detectivity of 7.6 × 1011 Jones.

Interaction of thymidylate synthase with pyridoxal 5'-phosphate as studied by UV/visible difference spectroscopy and molecular modeling

Biochemistry ◽  
1993 ◽  
Vol 32 (44) ◽  
pp. 11819-11824 ◽  
Author(s):  
Daniel V. Santi ◽  
Tian Mei Ouyang ◽  
Anthony K. Tan ◽  
Donald H. Gregory ◽  
Thomas Scanlan ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Thymidylate Synthase ◽  
Difference Spectroscopy ◽  
Uv Visible

UV Spectrophotometric Method Development and Validation of Carbimazole in Bulk and Tablet Dosage form

2021 ◽  
pp. 163-166
Author(s):  
Zainab A. Bagalkote ◽  
Ganesh Gajeli
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Method Development ◽  
Uv Spectrum ◽  
Highly Sensitive ◽  
Method Development And Validation ◽  
Uv Visible ◽  
Development And Validation ◽  
Tablet Dosage ◽  
The Given

Objective: A new, simple, sensitive, precise, reproducible UV visible spectrophotometric method was developed for the estimation of Carbimazole in Tablet dosage form. Methods: The UV spectrum of Carbimazole in methanol and distilled water (30:70) showed λ max at 289.6nm. Beer’s law is valid in the concentration range of 10-50µg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 10-50µg/ml with the regression equation y = 0.0232x + 0.0466, and regression coefficient i.e, r2= 0.9992 moreover, the method was found to be highly sensitive with LOD (1.818µg/ml) and LOQ (5.509µg/ml). Conclusion: From the results it can be concluded that the given method can be successfully applied for assay of Carbimazole in Tablet dosage form.

scholarly journals UV VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF DASATINIB IN BULK AND SOLID DOSAGE FORM

2020 ◽  
pp. 90-93
Author(s):  
SAILI MADUR ◽  
VINOD MATOLE ◽  
MALLINATH KALSHETTI
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Method Development ◽  
Uv Spectrum ◽  
Solid Dosage ◽  
Highly Sensitive ◽  
Method Development And Validation ◽  
Uv Visible ◽  
Development And Validation ◽  
Tablet Dosage

Objective: A new, simple, sensitive, precise, reproducible UV visible spectrophotometric method was developed for the determination of Dasatinib in Tablet dosage form with­­­ methanol. Methods: The method is based on the formation of a colorlesscomplex. The UV spectrum of Dasatinib in methanol showed maximum wavelength at 248 nm. Beer’s law is valid in the concentration range of 7-35µg/ml. this method was validated for linearity, accuracy, precision, assay, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 7-35µg/ml with the regression equation y = 0.0332x+0.0633 and regression coefficient i.e. r2= 0.9994moreover, the method was found to be highly sensitive with LOD(1.08µg/ml) and LOQ(3.29µg/ml). Conclusion: Based on the results the proposed method can be successfully applied for the assay of Dasatinib in various tablet dosage forms.

scholarly journals DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF TADALAFIL IN BULK AND FORMULATION

2020 ◽  
pp. 74-77
Author(s):  
SHRISHAIL M. GHURGHURE ◽  
MANISHA S. DYAWARKONDA ◽  
SACHIN YANJANE
Keyword(s):  
Dimethyl Sulfoxide ◽  
Spectroscopic Method ◽  
Dosage Forms ◽  
Uv Spectrum ◽  
Pharmaceutical Dosage Forms ◽  
Highly Sensitive ◽  
Uv Visible ◽  
Development And Validation ◽  
Regression Correlation

Objective: A new simple, sensitive, precise and reproducible spectroscopic method was developed for the determination of Tadalafil in Pharmaceutical formulation with Dimethyl Sulfoxide. Methods: The UV spectrum of Tadalafil in Dimethyl sulfoxide (DMSO) showed λ max at 285.6 nm. Beer’s law is valid in the concentration range of 10-60µg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness. Results: The method was demonstrated excellent linearity over the range of 10-60µg/ml with regression equation y= 0.0337x-0.1343 and regression correlation R2= 0.998. Moreover, the method was found to be highly sensitive with LOD (2.44µg/ml) and LOQ (7.40µg/ml). Conclusion: Based on results, the proposed method can be successfully applied for assay of Tadalafil in various pharmaceutical dosage forms.

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