Evaluating Atmospheric pressure Solids Analysis Probe (ASAP) mass spectrometry for the analysis of low molecular weight synthetic polymers

The Analyst ◽  
2012 ◽  
Vol 137 (19) ◽  
pp. 4524 ◽  
Author(s):  
Michael J. P. Smith ◽  
Neil R. Cameron ◽  
Jackie A. Mosely
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Atmospheric Pressure ◽  
Synthetic Polymers ◽  
Low Molecular Weight ◽  
Solids Analysis

scholarly journals FAPA mass spectrometry of hydroxychalcones. Comparative studies with classical methods of ionization

2014 ◽  
Vol 27 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Marek Smoluch ◽  
Grazyna Bartkowiak ◽  
Edward Reszke ◽  
Wojciech Lechowicz ◽  
Jerzy Silberring ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Comparative Studies ◽  
Atmospheric Pressure ◽  
Ion Sources ◽  
Low Molecular Weight ◽  
Fragmentation Pathways ◽  
Low Molecular Weight Compounds ◽  
Flowing Atmospheric Pressure Afterglow ◽  
Comparison Of The Results

Abstract In this paper we are focused on analysis of hydroxychalcones, i.e. 2’-hydroxychalcone, 3’-hydroxychalcone and 4’-hydroxychalcone, by the Flowing Atmospheric Pressure Afterglow mass spectrometry (FAPA-MS), and on comparison of the obtained data with other classical methods including ESI-MS, APCI, MALDI, and GC/EI-MS. The paper is presenting fragmentation pathways of both positive-, and negative hydroxychalcone ions. Tested compounds were characterized by comparison of the results (signals m/z and relative intensities) from the five mass spectrometry techniques, showing very good utility of FAPA method for fast and easy analysis of the low molecular weight compounds. Moreover, FAPA does not require a time-consuming derivatization, nor search for a suitable solvent or matrix, often incompatible with various ion sources.

scholarly journals Atmospheric pressure chemical ionisation mass spectrometry for the routine analysis of low molecular weight analytes

2021 ◽  
pp. 146906672110050
Author(s):  
Paul J Gates
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Atmospheric Pressure ◽  
Chemical Space ◽  
Negative Ion ◽  
Routine Analysis ◽  
Low Molecular Weight ◽  
Electrospray Ionisation ◽  
Pressure Chemical ◽  
Chemical Ionisation

The routine analysis of low molecular weight analytes by mass spectrometry is often complicated by the lability of the analyte’s functional groups and/or the lack of moieties that can be easily charged. If a molecule is too labile this precludes analysis by techniques such as electron ionisation or chemical ionisation as the analyte will undergo thermal decomposition prior to ionisation as well as spontaneous fragmentation during the ionisation process. If the analyte has a low propensity to form ions in electrospray ionisation (i.e., lacks acidic or basic sites) then often no analyte related ions are observed. In this paper, the robustness and versatility of the established method of atmospheric pressure chemical ionisation is demonstrated for the analysis of low molecular weight analytes. The utility of the technique is demonstrated through the analysis of 30 reference standards of varying functionality, and further by the analysis of 75 synthetic samples which were problematic when analysed by electron or electrospray ionisation. The resulting spectra are dominated by intact molecular species ([M+H]+ and M+ in positive ion mode and [M − H]− and [M + Cl]− in negative ion mode) along with logical neutral losses reminiscent of what you might expect from the analyte’s structure (losses of H2O from alcohols or CO from aldehydes etc). This paper presents atmospheric pressure chemical ionisation as an essential tool for broadening the chemical space of successful analyses for any routine mass spectrometry service laboratory of facility.

A novel trityl/acridine derivatization agent for analysis of thiols by (matrix-assisted)(nanowire-assisted)laser desorption/ionization and electrospray ionization mass spectrometry

2017 ◽  
Vol 9 (45) ◽  
pp. 6335-6340 ◽  
Author(s):  
Artyom P. Topolyan ◽  
Maria A. Belyaeva ◽  
Mariya S. Slyundina ◽  
Valentina V. Ilyushenkova ◽  
Andrey A. Formanovsky ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Laser Desorption ◽  
Fixed Charge ◽  
Low Molecular Weight ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization

A new agent was used for fixed-charge derivatization of low molecular weight thiols.

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