scholarly journals Label-free electrical detection of pyrophosphate generated from DNA polymerase reactions on field-effect devices

The Analyst ◽  
2012 ◽  
Vol 137 (6) ◽  
pp. 1351 ◽  
Author(s):  
Grace M. Credo ◽  
Xing Su ◽  
Kai Wu ◽  
Oguz H. Elibol ◽  
David J. Liu ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Field Effect ◽  
Label Free ◽  
Electrical Detection ◽  
Field Effect Devices

scholarly journals Label-free Electrostatic Detection of DNA Amplification by PCR Using Capacitive Field-effect Devices

2016 ◽  
Vol 168 ◽  
pp. 514-517 ◽  
Author(s):  
A. Poghossian ◽  
T.S. Bronder ◽  
S. Scheja ◽  
C. Wu ◽  
T. Weinand ◽  
...  
Keyword(s):  
Field Effect ◽  
Dna Amplification ◽  
Label Free ◽  
Field Effect Devices

Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling

2012 ◽  
Vol 209 (5) ◽  
pp. 925-934 ◽  
Author(s):  
Maryam H. Abouzar ◽  
Arshak Poghossian ◽  
Andrey G. Cherstvy ◽  
Angela M. Pedraza ◽  
Sven Ingebrandt ◽  
...  
Keyword(s):  
Field Effect ◽  
Label Free ◽  
Electrical Detection

scholarly journals Field-Effect Sensors for Virus Detection: From Ebola to SARS-CoV-2 and Plant Viral Enhancers

2020 ◽  
Vol 11 ◽  
Author(s):  
Arshak Poghossian ◽  
Melanie Jablonski ◽  
Denise Molinnus ◽  
Christina Wege ◽  
Michael J. Schöning
Keyword(s):  
Field Effect ◽  
Point Of Care ◽  
Virus Detection ◽  
Fast Response ◽  
Plant Viruses ◽  
Clinical Samples ◽  
Label Free ◽  
Label Free Detection ◽  
Field Effect Devices ◽  
Long Time

Coronavirus disease 2019 (COVID-19) is a novel human infectious disease provoked by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, no specific vaccines or drugs against COVID-19 are available. Therefore, early diagnosis and treatment are essential in order to slow the virus spread and to contain the disease outbreak. Hence, new diagnostic tests and devices for virus detection in clinical samples that are faster, more accurate and reliable, easier and cost-efficient than existing ones are needed. Due to the small sizes, fast response time, label-free operation without the need for expensive and time-consuming labeling steps, the possibility of real-time and multiplexed measurements, robustness and portability (point-of-care and on-site testing), biosensors based on semiconductor field-effect devices (FEDs) are one of the most attractive platforms for an electrical detection of charged biomolecules and bioparticles by their intrinsic charge. In this review, recent advances and key developments in the field of label-free detection of viruses (including plant viruses) with various types of FEDs are presented. In recent years, however, certain plant viruses have also attracted additional interest for biosensor layouts: Their repetitive protein subunits arranged at nanometric spacing can be employed for coupling functional molecules. If used as adapters on sensor chip surfaces, they allow an efficient immobilization of analyte-specific recognition and detector elements such as antibodies and enzymes at highest surface densities. The display on plant viral bionanoparticles may also lead to long-time stabilization of sensor molecules upon repeated uses and has the potential to increase sensor performance substantially, compared to conventional layouts. This has been demonstrated in different proof-of-concept biosensor devices. Therefore, richly available plant viral particles, non-pathogenic for animals or humans, might gain novel importance if applied in receptor layers of FEDs. These perspectives are explained and discussed with regard to future detection strategies for COVID-19 and related viral diseases.

A Dual-Gate Field-Effect Transistor for Label-Free Electrical Detection of Avian Influenza

2012 ◽  
Vol 2 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Jee-Yeon Kim ◽  
Jae-Hyuk Ahn ◽  
Dong-Il Moon ◽  
Sungho Kim ◽  
Tae Jung Park ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Label Free ◽  
Electrical Detection ◽  
Dual Gate ◽  
Effect Transistor

Monitoring Amyloid Sup35NM Growth with Label-Free Electrical Detection Using a Field-Effect Transistor Biosensor

2013 ◽  
Vol 1 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Sho Hideshima ◽  
Shofarul Wustoni ◽  
Shigeki Kuroiwa ◽  
Takuya Nakanishi ◽  
Ayumi Koike-Takeshita ◽  
...  
Keyword(s):  
Field Effect ◽  
Field Effect Transistor ◽  
Label Free ◽  
Electrical Detection ◽  
Effect Transistor

Label-free electronic detection of biomolecules using a-Si:H field-effect devices

2006 ◽  
Vol 352 (9-20) ◽  
pp. 2007-2010 ◽  
Author(s):  
D. Gonçalves ◽  
D.M.F. Prazeres ◽  
V. Chu ◽  
J.P. Conde
Keyword(s):  
Field Effect ◽  
Label Free ◽  
Electronic Detection ◽  
Field Effect Devices ◽  
Detection Of Biomolecules

scholarly journals Label-Free DNA Detection with Capacitive Field-Effect Devices—Challenges and Opportunities

Proceedings ◽  
2017 ◽  
Vol 1 (8) ◽  
pp. 719
Author(s):  
Michael J. Schöning ◽  
Thomas S. Bronder ◽  
Chunsheng Wu ◽  
Sabrina Scheja ◽  
Max Jessing ◽  
...  
Keyword(s):  
Field Effect ◽  
Dna Detection ◽  
Label Free ◽  
Free Dna ◽  
Challenges And Opportunities ◽  
Field Effect Devices
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