Determination of enantiomeric purity by an optically active nuclear magnetic resonance shift reagent of wide applicability

1971 ◽  
pp. 1450 ◽  
Author(s):  
Robert R. Fraser ◽  
Michel A. Petit ◽  
John K. Saunders
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Shift Reagent ◽  
Enantiomeric Purity ◽  
Optically Active ◽  
Wide Applicability ◽  
Resonance Shift ◽  
Nuclear Magnetic Resonance Shift ◽  
Nuclear Magnetic

Application of Chiral Lanthanide Nuclear Magnetic Resonance Shift Reagents to Pharmaceutical Analysis. II. Determination of Dextroand Levoamphetamine Mixtures

1981 ◽  
Vol 64 (4) ◽  
pp. 848-850
Author(s):  
Irving W Wainer ◽  
Lynda C Schneider ◽  
John D Weber
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Pharmaceutical Preparations ◽  
Shift Reagent ◽  
Resonance Shift ◽  
Bulk Drug ◽  
Optically Pure ◽  
Nuclear Magnetic Resonance Shift ◽  
Nuclear Magnetic

Abstract Optically pure d- and l-amphetamine sulfate, as well as various mixtures of the 2 enantiomers, were analyzed using a europium chiral nuclear magnetic resonance shift reagent. The enantiomeric shift difference (ΔΔδ) exhibited by the doublet associated with the α-methyl protons was large enough to differentiate between the levo- and dextro-isomers. The α-methyl protons were decoupled and the enantiomeric composition was determined by using the peak heights of the resulting singlets. As little as 5% of the levo-isomer in the presence of the dextro-isomer can be determined using this method. The method is applicable to the analysis of bulk drug and pharmaceutical preparations.

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