Synthesis and oxidation of 2-hydroxynevirapine, a metabolite of the HIV reverse transcriptase inhibitor nevirapine

2011 ◽  
Vol 9 (22) ◽  
pp. 7822 ◽  
Author(s):  
Alexandra M. M. Antunes ◽  
David A. Novais ◽  
J. L. Ferreira da Silva ◽  
Pedro P. Santos ◽  
M. Conceição Oliveira ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Transcriptase Inhibitor ◽  
Hiv Reverse Transcriptase ◽  
Reverse Transcriptase Inhibitor

Enzymatic kinetic studies with the non-nucleoside HIV reverse transcriptase inhibitor U-9843

1992 ◽  
Vol 48 (11-12) ◽  
pp. 1127-1132 ◽  
Author(s):  
I. W. Althaus ◽  
R. J. LeMay ◽  
A. J. Gonzales ◽  
M. R. Deibel ◽  
S. K. Sharma ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Kinetic Studies ◽  
Transcriptase Inhibitor ◽  
Hiv Reverse Transcriptase ◽  
Reverse Transcriptase Inhibitor

Swertifrancheside, an HIV-Reverse Transcriptase Inhibitor and the First Flavone-Xanthone Dimer, from Swertia franchetiana

1994 ◽  
Vol 57 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Jian-Nong Wang ◽  
Cui-Ying Hou ◽  
Yong-Long Liu ◽  
Long-Ze Lin ◽  
Roberto R. Gil ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Transcriptase Inhibitor ◽  
Hiv Reverse Transcriptase ◽  
Reverse Transcriptase Inhibitor

Current structure-based methods for designing non-nucleoside reverse transcriptase inhibitors

2019 ◽  
Vol 14 (8) ◽  
pp. 537-544
Author(s):  
Kathleen M Frey ◽  
Tasnim Tabassum
Keyword(s):  
Crystal Structure ◽  
Reverse Transcriptase ◽  
Nucleoside Reverse Transcriptase Inhibitor ◽  
Transcriptase Inhibitor ◽  
Hiv Reverse Transcriptase ◽  
Reverse Transcriptase Inhibitors ◽  
Antiretroviral Therapies ◽  
New Ideas ◽  
Inhibitor Drug ◽  
Reverse Transcriptase Inhibitor

In 2019, structure-based methods continue to guide the design of novel antiretroviral therapies targeting HIV reverse transcriptase. This Review summarizes key findings from reverse transcriptase–non-nucleoside reverse transcriptase inhibitor analog crystal structure complexes reported from 2015 to 2019. Results from the literature and structure analysis have informed new ideas for structure-guided non-nucleoside reverse transcriptase inhibitor drug design.

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