Strategies in biomimetic surface engineering of nanoparticles for biomedical applications

Nanoscale ◽  
2012 ◽  
Vol 4 (2) ◽  
pp. 360-368 ◽  
Author(s):  
Yong-kuan Gong ◽  
Françoise M. Winnik
Keyword(s):  
Biomedical Applications ◽  
Surface Engineering ◽  
Biomimetic Surface

scholarly journals Organic dots (O-dots) for theranostic applications: preparation and surface engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2253-2291
Author(s):  
Amin Shiralizadeh Dezfuli ◽  
Elmira Kohan ◽  
Sepand Tehrani Fateh ◽  
Neda Alimirzaei ◽  
Hamidreza Arzaghi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Surface Engineering ◽  
Graphene Quantum Dots ◽  
Carbon Quantum Dots ◽  
Cargo Delivery ◽  
Bio Imaging ◽  
Theranostic Applications

Organic dots is a term used to represent materials including graphene quantum dots and carbon quantum dots because they rely on the presence of other atoms (O, H, and N) for their photoluminescence or fluorescence properties. Cargo delivery, bio-imaging, photodynamic therapy and photothermal therapy are major biomedical applications of organic dots.

scholarly journals Surface Engineering of Graphene-Based Nanomaterials for Biomedical Applications

2014 ◽  
Vol 25 (9) ◽  
pp. 1609-1619 ◽  
Author(s):  
Sixiang Shi ◽  
Feng Chen ◽  
Emily B. Ehlerding ◽  
Weibo Cai
Keyword(s):  
Biomedical Applications ◽  
Surface Engineering

Surface Engineering of Polymers for Biomedical Applications

2018 ◽  
pp. 49-80
Author(s):  
H. J. Griesser ◽  
R. C. Chatelier ◽  
T. R. Gengenbach ◽  
Z. R. Vasic ◽  
G. Johnson ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Surface Engineering

scholarly journals Bioclickable and mussel adhesive peptide mimics for engineering vascular stent surfaces

2020 ◽  
Vol 117 (28) ◽  
pp. 16127-16137 ◽  
Author(s):  
Zhilu Yang ◽  
Xin Zhao ◽  
Rui Hao ◽  
Qiufen Tu ◽  
Xiaohua Tian ◽  
...  
Keyword(s):  
Surface Engineering ◽  
Vascular Stents ◽  
Biomimetic Surface ◽  
Cardiovascular Stents ◽  
Stent Restenosis ◽  
Clinical Complications ◽  
Engineering Strategy ◽  
Promising Solution ◽  
Targeting Peptide ◽  
Mussel Adhesive

Thrombogenic reaction, aggressive smooth muscle cell (SMC) proliferation, and sluggish endothelial cell (EC) migration onto bioinert metal vascular stents make poststenting reendothelialization a dilemma. Here, we report an easy to perform, biomimetic surface engineering strategy for multiple functionalization of metal vascular stents. We first design and graft a clickable mussel-inspired peptide onto the stent surface via mussel-inspired adhesion. Then, two vasoactive moieties [i.e., the nitric-oxide (NO)-generating organoselenium (SeCA) and the endothelial progenitor cell (EPC)-targeting peptide (TPS)] are clicked onto the grafted surfaces via bioorthogonal conjugation. We optimize the blood and vascular cell compatibilities of the grafted surfaces through changing the SeCA/TPS feeding ratios. At the optimal ratio of 2:2, the surface-engineered stents demonstrate superior inhibition of thrombosis and SMC migration and proliferation, promotion of EPC recruitment, adhesion, and proliferation, as well as prevention of in-stent restenosis (ISR). Overall, our biomimetic surface engineering strategy represents a promising solution to address clinical complications of cardiovascular stents and other blood-contacting metal materials.

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