LC– and CZE–ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(iii)] (KP1339) in mouse plasma

Metallomics ◽  
2011 ◽  
Vol 3 (10) ◽  
pp. 1049 ◽  
Author(s):  
Anna K. Bytzek ◽  
Katharina Boeck ◽  
Gerrit Hermann ◽  
Stephan Hann ◽  
Bernhard K. Keppler ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Candidate ◽  
Mouse Plasma ◽  
Icp Ms ◽  
In Vivo Analysis

In Vitro and In Vivo Investigations into the Carbene Copper Bromide Anticancer Drug Candidate WBC4

2014 ◽  
Vol 11 (7) ◽  
pp. 825-832 ◽  
Author(s):  
Wolfgang Walther ◽  
Iduna Fichtner ◽  
Frauke Hackenberg ◽  
Wojciech Streciwilk ◽  
Matthias Tacke
Keyword(s):  
Anticancer Drug ◽  
Drug Candidate ◽  
Copper Bromide

In-Silico Analysis to Identify Potential Inhibitors Against the Protein NSP12 of SARS-CoV-2

2021 ◽  
Vol 6 (3) ◽  
pp. 48-60
Author(s):  
Hima Vyshnavi ◽  
Gayathri S. S. ◽  
Shahanas Naisam ◽  
Suvanish Kumar ◽  
Nidhin Sreekumar
Keyword(s):  
In Silico ◽  
Interaction Analysis ◽  
In Silico Analysis ◽  
Drug Efficacy ◽  
Drug Candidate ◽  
In Vivo Analysis ◽  
The Stability ◽  
Potential Inhibitors ◽  
Silico Analysis

In this pandemic condition, a drug candidate which is effective against COVID-19 is very much desired. This study initiates an in silico analysis to screen small molecules such as phytochemicals, drug metabolites, and natural metabolites against Nsp12 (a catalytic unit for RNA transcription and replication). Molecular interaction analysis of 6M71 was carried out against 2,860 ligands using Schrodinger Glide software. After docking analysis, the top 10 molecules (Glide score) were subjected to MD simulation for validating the stability. It resulted in top 10 compounds with high binding affinities with the target molecule NSP 12. Out of these, top 3 compounds including PSID_08_LIG3 (HMDB0133544), PSID_08_LIG4 (HMDB0132898), and PSID_08_LIG9 (HMDB0128199) show better Glide scores, better H-bond interaction, better MMGBSA value and stability on dynamic simulation after analysis of the results. The suggested ligands can be postulated as effective antiviral drugs against COVID-19. Further in vivo analysis is needed for validating the drug efficacy.

In Vitro and In Vivo Investigations into the Carbene Silver Acetate Anticancer Drug Candidate SBC1

2012 ◽  
Vol 9 (9) ◽  
pp. 815-822 ◽  
Author(s):  
Iduna Fichtner ◽  
Jindrich Cinatl ◽  
Martin Michaelis ◽  
Lara C. Sanders ◽  
Ralf Hilger ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Candidate ◽  
Silver Acetate

Abcb1a (P-glycoprotein) limits brain exposure of the anticancer drug candidate seliciclib in vivo in adult mice

2017 ◽  
Vol 132 ◽  
pp. 232-236 ◽  
Author(s):  
Franciska Erdő ◽  
Ildikó Nagy ◽  
Beáta Tóth ◽  
Annamária Bui ◽  
Éva Molnár ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Candidate ◽  
Adult Mice ◽  
P Glycoprotein ◽  
Brain Exposure

scholarly journals Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS

The Analyst ◽  
2017 ◽  
Vol 142 (17) ◽  
pp. 3165-3176 ◽  
Author(s):  
Karla Pelivan ◽  
Lisa Frensemeier ◽  
Uwe Karst ◽  
Gunda Koellensperger ◽  
Bjoern Bielec ◽  
...  
Keyword(s):  
Electrochemical Oxidation ◽  
Anticancer Drug ◽  
In Vivo Analysis ◽  
Microsomal Incubation

The metabolism of the anticancer thiosemicarbazone Triapine was investigated.

Meiotic CENP-C is a shepherd: bridging the space between the centromere and the kinetochore in time and space

2020 ◽  
Vol 64 (2) ◽  
pp. 251-261
Author(s):  
Jessica E. Fellmeth ◽  
Kim S. McKim
Keyword(s):  
Chromosome Segregation ◽  
New Technologies ◽  
Early Prophase ◽  
Unique Role ◽  
Kinetochore Assembly ◽  
M Phase ◽  
In Vivo Analysis ◽  
Meiosis I

Abstract While many of the proteins involved in the mitotic centromere and kinetochore are conserved in meiosis, they often gain a novel function due to the unique needs of homolog segregation during meiosis I (MI). CENP-C is a critical component of the centromere for kinetochore assembly in mitosis. Recent work, however, has highlighted the unique features of meiotic CENP-C. Centromere establishment and stability require CENP-C loading at the centromere for CENP-A function. Pre-meiotic loading of proteins necessary for homolog recombination as well as cohesion also rely on CENP-C, as do the main scaffolding components of the kinetochore. Much of this work relies on new technologies that enable in vivo analysis of meiosis like never before. Here, we strive to highlight the unique role of this highly conserved centromere protein that loads on to centromeres prior to M-phase onset, but continues to perform critical functions through chromosome segregation. CENP-C is not merely a structural link between the centromere and the kinetochore, but also a functional one joining the processes of early prophase homolog synapsis to late metaphase kinetochore assembly and signaling.

1059: In Vivo Analysis of Chronic Phosphodiesterase-5 Inhibition in Penile Erectile Tissue: No Tachyphylaxis Effect

2005 ◽  
Vol 173 (4S) ◽  
pp. 287-287
Author(s):  
Anhur L. Burnett ◽  
Hunter C. Champion ◽  
Robyn E. Becker ◽  
Melissa F. Kramer ◽  
Tongyun Liu ◽  
...  
Keyword(s):  
Erectile Tissue ◽  
In Vivo Analysis ◽  
Phosphodiesterase 5

In vivo Analysis of Murine Pneumococcal Pneumonia for Mathematical Modelling of Community Aquired Pneumonia

Pneumologie ◽  
2017 ◽  
Vol 71 (S 01) ◽  
pp. S1-S125
Author(s):  
S Berger ◽  
C Gökeri ◽  
U Behrendt ◽  
SM Wienhold ◽  
J Lienau ◽  
...  
Keyword(s):  
Mathematical Modelling ◽  
Pneumococcal Pneumonia ◽  
In Vivo Analysis ◽  
Community Aquired Pneumonia

Regulation of glucose uptake and metabolism by working muscle. An in vivo analysis

Diabetes ◽  
1993 ◽  
Vol 42 (7) ◽  
pp. 956-965 ◽  
Author(s):  
B. A. Zinker ◽  
D. B. Lacy ◽  
D. Bracy ◽  
J. Jacobs ◽  
D. H. Wasserman
Keyword(s):  
Glucose Uptake ◽  
In Vivo Analysis ◽  
Uptake And Metabolism
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