Localized flexible integration of high-efficiency surface enhanced Raman scattering (SERS) monitors into microfluidic channels

Lab on a Chip ◽  
2011 ◽  
Vol 11 (19) ◽  
pp. 3347 ◽  
Author(s):  
Bin-Bin Xu ◽  
Zhuo-Chen Ma ◽  
Lei Wang ◽  
Ran Zhang ◽  
Li-Gang Niu ◽  
...  
Keyword(s):  
Raman Scattering ◽  
High Efficiency ◽  
Surface Enhanced Raman Scattering ◽  
Microfluidic Channels ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Flexible Integration ◽  
Enhanced Raman Scattering

Surface-enhanced Raman scattering (SERS) chips made from metal nanoparticle-doped polymer fibers

RSC Advances ◽  
2014 ◽  
Vol 4 (45) ◽  
pp. 23838-23845 ◽  
Author(s):  
Wenran Gao ◽  
Gang Chen ◽  
Weiqing Xu ◽  
Chenggong Yang ◽  
Shuping Xu
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Metal Nanoparticle ◽  
Microfluidic Channels ◽  
Polymer Nanofiber ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Nanofiber Mats ◽  
Doped Polymer

We employed an electrospinning method to prepare metal nanoparticle (NP) doped polymer nanofiber mats, which can be easily cut to size and fixed on slides or in microfluidic channels for surface-enhanced Raman scattering (SERS) measurements.

Three-Dimensional Surface-Enhanced Raman Scattering Substrate Fabricated Using Chemical Decoration of Silver Nanoparticles on Electrospun Polycarbonate Nanofibers

2016 ◽  
Vol 71 (5) ◽  
pp. 879-887 ◽  
Author(s):  
Murugesan Balamurugan ◽  
Jyisy Yang
Keyword(s):  
Silver Nanoparticles ◽  
Raman Scattering ◽  
High Efficiency ◽  
Three Dimensional ◽  
Surface Enhanced Raman Scattering ◽  
Simple Method ◽  
Sers Substrates ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

In this work, a simple method via decoration of silver nanoparticles (AgNPs) on electrospun polycarbonate nanofibers (PCNFs) was proposed to prepare highly sensitive three-dimensional (3D) substrates for surface-enhanced Raman scattering (SERS) measurements. The method proposed in this work gave a high sensitive Ag@PCNFs substrate, which resulted from a successful production of high surface area of PCNFs with a high efficiency in the decoration of AgNPs. To produce PCNFs suitable for SERS application, parameters in fabrication of PCNFs were systematically examined and correlated with their corresponding scanning electron microscope (SEM) images. Examined parameters included the concentration of PC solution, the solvent to form PC solution, the applied voltage, and the rotating speed of a drum collector. Using the optimized condition, the bead-free PCNFs with a diameter in the range of 200–400 nm were successfully produced. To increase the efficiency in decoration of AgNPs, the surface properties of PNCFs were altered with an organic solvent, which was selected experimentally with guidance of Hildebrand solubility parameter. Results indicated that methanol was the most suitable solvent to effectively decorate AgNPs on PCNFs. By probing with para-hydroxythiophenol (pHTP), prepared SERS substrates of Ag@PCNFs provided an enhancement factor to the order of 7, which is at least an order of magnitude larger than the reported values in the literature for SERS substrates prepared with the electrospinning technique.

Fabrication of copper substrates for surface-enhanced Raman scattering using the microscratching method

2016 ◽  
Vol 232 (7) ◽  
pp. 1310-1315 ◽  
Author(s):  
Jingran Zhang ◽  
Yongda Yan ◽  
Zhenjiang Hu ◽  
Xuesen Zhao
Keyword(s):  
Raman Scattering ◽  
High Efficiency ◽  
Normal Load ◽  
High Surface ◽  
Surface Enhanced Raman Scattering ◽  
Crystallographic Plane ◽  
Nano Structures ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

The method of a tip-based microscratching is used to fabricate micro/nano structures on single crystal copper (110) and (111) planes under room temperature. The surface-enhanced Raman scattering enhancement performance of the structured Cu surface has been studied by rhodamine 6G probe molecules. Such micro/nano structures can be machined by varying the scratching parameters such as the feed and the normal load. Experimental results show that the high surface-enhanced Raman scattering enhancement is attributed to the nanostructures formed by pile-ups between adjacent grooves and nanocracks at the bottom of the microsquare. In addition, the Raman intensity of the crystallographic plane (110) is stronger than that of the crystallographic plane (111). This work verifies that the microscratching method is a feasible way to machine active surface-enhanced Raman scattering substrates on Cu surfaces with low cost and high efficiency.

scholarly journals Facile fabrication of microfluidic surface-enhanced Raman scattering devices via lift-up lithography

2018 ◽  
Vol 5 (4) ◽  
pp. 172034 ◽  
Author(s):  
Yuanzi Wu ◽  
Ye Jiang ◽  
Xiaoshan Zheng ◽  
Shasha Jia ◽  
Zhi Zhu ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Soft Lithography ◽  
Low Cost ◽  
Surface Enhanced Raman Scattering ◽  
Microfluidic Channels ◽  
Sers Substrate ◽  
Microfluidic Chips ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

We describe a facile and low-cost approach for a flexibly integrated surface-enhanced Raman scattering (SERS) substrate in microfluidic chips. Briefly, a SERS substrate was fabricated by the electrostatic assembling of gold nanoparticles, and shaped into designed patterns by subsequent lift-up soft lithography. The SERS micro-pattern could be further integrated within microfluidic channels conveniently. The resulting microfluidic SERS chip allowed ultrasensitive in situ SERS monitoring from the transparent glass window. With its advantages in simplicity, functionality and cost-effectiveness, this method could be readily expanded into optical microfluidic fabrication for biochemical applications.

scholarly journals Immobilization and 3D Hot-Junction Formation of Gold Nanoparticles on Two-Dimensional Silicate Nanoplatelets as Substrates for High-Efficiency Surface-Enhanced Raman Scattering Detection

Nanomaterials ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 324 ◽  
Author(s):  
Yen-Chen Lee ◽  
Chih-Wei Chiu
Keyword(s):  
Gold Nanoparticles ◽  
Raman Scattering ◽  
High Efficiency ◽  
Surface Enhanced Raman Scattering ◽  
Detection Sensitivity ◽  
Sers Substrate ◽  
Two Dimensional ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

We synthesize a high-efficiency substrate for surface-enhanced Raman scattering (SERS) measurements, which is composed of gold nanoparticles (AuNPs) on two-dimensional silicate nanoplatelets acting as an inorganic stabilizer, via the in-situ reduction of hydrogen tetrachloroaurate (III) by sodium citrate in an aqueous solution. Silicate platelets of ~1-nm thickness and various sizes, viz. laponite (50 nm), sodium montmorillonite (Na+–MMT, 100 nm), and mica (500 nm), are used to stabilize the AuNPs (Au@silicate), which are formed with uniform diameters ranging between 25 and 30 nm as confirmed by transmission electron microscopy (TEM). In particular, the laponite SERS substrate can be used in biological, environmental, and food safety applications to measure small molecules such as DNA (adenine molecule), dye (Direct Blue), and herbicide (paraquat) as it shows high detection sensitivity with a detection limit of 10−9 M for adenine detection. These highly sensitive SERS substrates, with their three-dimensional hot-junctions formed with AuNPs and two-dimensional silicate nanoplatelets, allow the highly efficient detection of organic molecules. Therefore, these Au@silicate nanohybrid substrates have great potential in biosensor technology because of their environmentally-friendly and simple fabrication process, high efficiency, and the possibility of rapid detection.

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