Engineered approaches to the stem cell microenvironment for cardiac tissue regeneration

Lab on a Chip ◽  
2011 ◽  
Vol 11 (18) ◽  
pp. 3031 ◽  
Author(s):  
Ebrahim Ghafar-Zadeh ◽  
John R. Waldeisen ◽  
Luke P. Lee
Keyword(s):  
Stem Cell ◽  
Tissue Regeneration ◽  
Cardiac Tissue ◽  
Cell Microenvironment

Stem Cell Engineering for Cardiac Tissue Regeneration

Cardiology ◽  
2010 ◽  
Vol 115 (3) ◽  
pp. 191-193 ◽  
Author(s):  
Masashi Yoshida ◽  
Hidemasa Oh
Keyword(s):  
Stem Cell ◽  
Tissue Regeneration ◽  
Cardiac Tissue ◽  
Cell Engineering ◽  
Stem Cell Engineering

scholarly journals Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration

2020 ◽  
Vol 21 (13) ◽  
pp. 4770 ◽  
Author(s):  
Yi-Hsiung Lin ◽  
Lin Kang ◽  
Wen-Han Feng ◽  
Tsung-Lin Cheng ◽  
Wei-Chung Tsai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Blood Lipids ◽  
Cardiac Tissue ◽  
Lipid Lowering ◽  
Lipids And Lipoproteins ◽  
Msc Differentiation

Mesenchymal stem cells (MSCs) have two characteristics of interest for this paper: the ability to self-renew, and the potential for multiple-lineage differentiation into various cells. MSCs have been used in cardiac tissue regeneration for over a decade. Adult cardiac tissue regeneration ability is quite low; it cannot repair itself after injury, as the heart cells are replaced by fibroblasts and lose function. It is therefore important to search for a feasible way to repair and restore heart function through stem cell therapy. Stem cells can differentiate and provide a source of progenitor cells for cardiomyocytes, endothelial cells, and supporting cells. Studies have shown that the concentrations of blood lipids and lipoproteins affect cardiovascular diseases, such as atherosclerosis, hypertension, and obesity. Furthermore, the MSC lipid profiles, such as the triglyceride and cholesterol content, have been revealed by lipidomics, as well as their correlation with MSC differentiation. Abnormal blood lipids can cause serious damage to internal organs, especially heart tissue. In the past decade, the accumulated literature has indicated that lipids/lipoproteins affect stem cell behavior and biological functions, including their multiple lineage capability, and in turn affect the outcome of regenerative medicine. This review will focus on the effect of lipids/lipoproteins on MSC cardiac regenerative medicine, as well as the effect of lipid-lowering drugs in promoting cardiomyogenesis-associated MSC differentiation.

Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration

Biomaterials ◽  
2011 ◽  
Vol 32 (10) ◽  
pp. 2508-2515 ◽  
Author(s):  
Chunying Shi ◽  
Qingguo Li ◽  
Yannan Zhao ◽  
Wei Chen ◽  
Bing Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tissue Regeneration ◽  
Cardiac Tissue ◽  
Collagen Scaffold

scholarly journals Biomaterials Loaded with Growth Factors/Cytokines and Stem Cells for Cardiac Tissue Regeneration

2020 ◽  
Vol 21 (17) ◽  
pp. 5952 ◽  
Author(s):  
Saltanat Smagul ◽  
Yevgeniy Kim ◽  
Aiganym Smagulova ◽  
Kamila Raziyeva ◽  
Ayan Nurkesh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Stem Cells ◽  
Stem Cell ◽  
Tissue Regeneration ◽  
Tissue Damage ◽  
Cardiac Tissue ◽  
Heart Function ◽  
Left Ventricle Remodeling ◽  
And Migration

Myocardial infarction causes cardiac tissue damage and the release of damage-associated molecular patterns leads to activation of the immune system, production of inflammatory mediators, and migration of various cells to the site of infarction. This complex response further aggravates tissue damage by generating oxidative stress, but it eventually heals the infarction site with the formation of fibrotic tissue and left ventricle remodeling. However, the limited self-renewal capability of cardiomyocytes cannot support sufficient cardiac tissue regeneration after extensive myocardial injury, thus, leading to an irreversible decline in heart function. Approaches to improve cardiac tissue regeneration include transplantation of stem cells and delivery of inflammation modulatory and wound healing factors. Nevertheless, the harsh environment at the site of infarction, which consists of, but is not limited to, oxidative stress, hypoxia, and deficiency of nutrients, is detrimental to stem cell survival and the bioactivity of the delivered factors. The use of biomaterials represents a unique and innovative approach for protecting the loaded factors from degradation, decreasing side effects by reducing the used dosage, and increasing the retention and survival rate of the loaded cells. Biomaterials with loaded stem cells and immunomodulating and tissue-regenerating factors can be used to ameliorate inflammation, improve angiogenesis, reduce fibrosis, and generate functional cardiac tissue. In this review, we discuss recent findings in the utilization of biomaterials to enhance cytokine/growth factor and stem cell therapy for cardiac tissue regeneration in small animals with myocardial infarction.

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