A new hybrid scaffold using rapid prototyping and electrohydrodynamic direct writing for bone tissue regeneration

2011 ◽  
Vol 21 (47) ◽  
pp. 19138 ◽  
Author(s):  
Geun Hyung Kim ◽  
Seung Hyun Ahn ◽  
Hyeong Jin Lee ◽  
SuYeon Lee ◽  
Youngseok Cho ◽  
...  
Author(s):  
R. Fradique ◽  
T. R. Correia ◽  
S. P. Miguel ◽  
K. D. de Sá ◽  
D. R. Figueira ◽  
...  

RSC Advances ◽  
2016 ◽  
Vol 6 (60) ◽  
pp. 55022-55032 ◽  
Author(s):  
Jae Yoon Lee ◽  
Woo-Jae Chung ◽  
GeunHyung Kim

A hybrid scaffold (M13-phage/alginate and PCL) was proposed as a biomedical scaffold.


2016 ◽  
Vol 24 (4) ◽  
pp. 1013-1023 ◽  
Author(s):  
Pranav S. Sapkal ◽  
Abhaykumar M. Kuthe ◽  
Rajpal S. Kashyap ◽  
Amit R. Nayak ◽  
Sudhanshu A. Kuthe ◽  
...  

2016 ◽  
Vol 23 (4) ◽  
pp. 927-935 ◽  
Author(s):  
Pranav S. Sapkal ◽  
Abhaykumar M. Kuthe ◽  
Rajpal S. Kashyap ◽  
Amit R. Nayak ◽  
Sudhanshu A. Kuthe ◽  
...  

2016 ◽  
Vol 5 (4) ◽  
pp. 79 ◽  
Author(s):  
Pranav S. Sapkal ◽  
Shraddha Jaiswal ◽  
Abhaykumar M. Kuthe

<p class="1Body">The review article focuses on Rapid Prototyped assisted scaffold fabrication for bone tissue regeneration, particularly in respect of its mechanical properties and cell culture abilities. The distinct feature of computer aided design and computer aided manufacturing (CAD &amp; CAM), imaging technology and rapid prototyping (RP) technology has been used by different researchers to print porous scaffolds with requisite shape and interconnected channels for osseous tissue formation. This study concludes that the use of RP in scaffold manufacturing offers patient specific designed scaffolds<strong> </strong>with improved strength, in-vitro and in-vivo cell culture capability unlike traditional scaffold fabrication techniques. Tissue engineering using 3D Printing is a viable substitute for organ transplant, which<strong> </strong>requires willing donors to part with their organs. This study reviewed the benefits of RP/imaging/CAD-CAM to develop scaffolds for bone<strong> </strong>tissue regeneration and it serves those patients who could not be accurately treated by traditional means. The article is helpful to study the influence of RP in the field of organ transplant</p>


2020 ◽  
Vol 27 (6) ◽  
pp. 838-853 ◽  
Author(s):  
Madalina Icriverzi ◽  
Valentina Dinca ◽  
Magdalena Moisei ◽  
Robert W. Evans ◽  
Mihaela Trif ◽  
...  

: Among the multiple properties exhibited by lactoferrin (Lf), its involvement in bone regeneration processes is of great interest at the present time. A series of in vitro and in vivo studies have revealed the ability of Lf to promote survival, proliferation and differentiation of osteoblast cells and to inhibit bone resorption mediated by osteoclasts. Although the mechanism underlying the action of Lf in bone cells is still not fully elucidated, it has been shown that its mode of action leading to the survival of osteoblasts is complemented by its mitogenic effect. Activation of several signalling pathways and gene expression, in an LRPdependent or independent manner, has been identified. Unlike the effects on osteoblasts, the action on osteoclasts is different, with Lf leading to a total arrest of osteoclastogenesis. : Due to the positive effect of Lf on osteoblasts, the potential use of Lf alone or in combination with different biologically active compounds in bone tissue regeneration and the treatment of bone diseases is of great interest. Since the bioavailability of Lf in vivo is poor, a nanotechnology- based strategy to improve the biological properties of Lf was developed. The investigated formulations include incorporation of Lf into collagen membranes, gelatin hydrogel, liposomes, loading onto nanofibers, porous microspheres, or coating onto silica/titan based implants. Lf has also been coupled with other biologically active compounds such as biomimetic hydroxyapatite, in order to improve the efficacy of biomaterials used in the regulation of bone homeostasis. : This review aims to provide an up-to-date review of research on the involvement of Lf in bone growth and healing and on its use as a potential therapeutic factor in bone tissue regeneration.


Author(s):  
Bipin Gaihre ◽  
Xifeng Liu ◽  
Linli Li ◽  
A. Lee Miller ◽  
Emily T. Camilleri ◽  
...  

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