Bio-modified Fe3O4core/Au shell nanoparticles for targeting and multimodal imaging of cancer cells

2012 ◽  
Vol 22 (2) ◽  
pp. 470-477 ◽  
Author(s):  
Ting Zhou ◽  
Baoyan Wu ◽  
Da Xing
Keyword(s):  
Cancer Cells ◽  
Multimodal Imaging ◽  
Shell Nanoparticles

Iron Oxide-Gold Core-Shell Nanoparticles as Multimodal Imaging Contrast Agent

2013 ◽  
Vol 13 (6) ◽  
pp. 2341-2347 ◽  
Author(s):  
Luca Menichetti ◽  
Leonardo Manzoni ◽  
Luigi Paduano ◽  
A. Flori ◽  
Claudia Kusmic ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Multimodal Imaging ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Gold Core ◽  
Core Shell Nanoparticles ◽  
Imaging Contrast Agent

Docetaxel-loaded SiO2@Au@GO core–shell nanoparticles for chemo-photothermal therapy of cancer cells

RSC Advances ◽  
2016 ◽  
Vol 6 (54) ◽  
pp. 48379-48386 ◽  
Author(s):  
Xiaolin Li ◽  
Zhi Yang ◽  
Nantao Hu ◽  
Liying Zhang ◽  
Yafei Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Photothermal Therapy ◽  
Prostate Cancer Cell ◽  
Core Shell ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

The multifunctional antitumor SiO2@Au@GO core–shell nanoparticles (NPs) have been fabricated for serving as drug nanocarrier and photothermal inducer to have a treatment on human prostate cancer cell DU 145.

Fabrication of gold–silver core–shell nanoparticles for performing as ultrabright SERS-nanotags inside human ovarian cancer cells

2019 ◽  
Vol 30 (31) ◽  
pp. 315701 ◽  
Author(s):  
Alexandru-Milentie Hada ◽  
Monica Potara ◽  
Sorina Suarasan ◽  
Adriana Vulpoi ◽  
Timea Nagy-Simon ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Core Shell ◽  
Human Ovarian Cancer ◽  
Shell Nanoparticles ◽  
Gold Silver ◽  
Core Shell Nanoparticles ◽  
Silver Core

Multifunctional gadolinium-labeled silica-coated core/shell quantum dots for magnetic resonance and fluorescence imaging of cancer cells

RSC Advances ◽  
2014 ◽  
Vol 4 (40) ◽  
pp. 20641-20648 ◽  
Author(s):  
Babao Lin ◽  
Xiuzhong Yao ◽  
Yihua Zhu ◽  
Jianhua Shen ◽  
Xiaoling Yang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Magnetic Resonance ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
High Relaxivity ◽  
Core Shell Nanoparticles

Multifunctional gadolinium-labeled silica-coated core/shell nanoparticles with high relaxivity and photoluminescence were synthesized for dual-modal contrast.

Fabrication and Biofunctionalization of Selenium-Polypyrrole Core–Shell Nanoparticles for Targeting and Imaging of Cancer Cells

2008 ◽  
Vol 8 (5) ◽  
pp. 2488-2491 ◽  
Author(s):  
Jing-Liang Li ◽  
Xiang-Yang Liu
Keyword(s):  
Cancer Cells ◽  
Polymerization Process ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Cervical Cancer Cells ◽  
Core Shell Nanoparticles ◽  
Human Cervical Cancer Cells ◽  
Thermal Stability Of ◽  
Human Cervical Cancer

Selenium-polypyrrole core–shell nanoparticles are fabricated by an in-situ polymerization process and functionalized with transferrin for targeting and imaging of human cervical cancer cells. The shell thickness and chemical composition of the as-synthesized particles can be manipulated by controlling the precursor concentration. The presence of the polymer layer can greatly increase the thermal stability of the selenium nanoparticles. The presence of transferrin molecules on the surface of the core–shell nanoparticles can significantly enhance their cellular uptake. The tranferrin-conjugated core–shell nanoparticles can be potentially used for the targeting and imaging of cancer cells.

scholarly journals Development of Folic Acid-Conjugated and Methylene Blue-Adsorbed Au@TNA Nanoparticles for Enhanced Photodynamic Therapy of Bladder Cancer Cells

Nanomaterials ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1351
Author(s):  
Che-Wei Hsu ◽  
Nai-Chi Cheng ◽  
Mei-Yi Liao ◽  
Ting-Yu Cheng ◽  
Yi-Chun Chiu
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Au Nanoparticle ◽  
Shell Nanoparticles ◽  
High Accumulation ◽  
Bladder Cancer Cells ◽  
Promising Treatment ◽  
Core Shell Nanoparticles

Photodynamic therapy (PDT) is a promising treatment for malignancy. However, the low molecular solubility of photosensitizers (PSs) with a low accumulation at borderline malignant potential lesions results in the tardy and ineffective management of recurrent urothelial carcinoma. Herein, we used tannic acid (TNA), a green precursor, to reduce HAuCl4 in order to generate Au@TNA core-shell nanoparticles. The photosensitizer methylene blue (MB) was subsequently adsorbed onto the surface of the Au@TNA nanoparticles, leading to the incorporation of a PS within the organic shell of the Au nanoparticle nanosupport, denoted as Au@TNA@MB nanoparticles (NPs). By modifying the surface of the Au@TNA@MB NPs with the ligand folate acid (FA) using NH2-PEG-NH2 as a linker, we demonstrated that the targeted delivery strategy achieved a high accumulation of PSs in cancer cells. The cell viability of T24 cells decreased to 87.1%, 57.1%, and 26.6% upon treatment with 10 ppm[Au] Au@TNA/MB NPs after 45 min, 2 h, and 4 h of incubation, respectively. We also applied the same targeted PDT treatment to normal urothelial SV-HUC-1 cells and observed minor phototoxicity, indicating that this safe photomedicine shows promise for applications aiming to achieve the local depletion of cancer sites without side effects.

scholarly journals A DM1-doped porous gold nanoshell system for NIR accelerated redox-responsive release and triple modal imaging guided photothermal synergistic chemotherapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Pengcheng Xu ◽  
Ru Wang ◽  
Wenqian Yang ◽  
Yanyan Liu ◽  
Dongsheng He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Multimodal Imaging ◽  
Breast Cancer Cells ◽  
M2 Macrophage ◽  
Tumour Targeting ◽  
Porous Gold

Abstract Background Although many treatments for breast cancer are available, poor tumour targeting limits the effectiveness of most approaches. Consequently, it is difficult to achieve satisfactory results with monotherapies. The lack of accurate diagnostic and monitoring methods also limit the benefits of cancer treatment. The aim of this study was to design a nanocarrier comprising porous gold nanoshells (PGNSs) co-decorated with methoxy polyethylene glycol (mPEG) and trastuzumab (Herceptin®, HER), a therapeutic monoclonal antibody that binds specifically to human epidermal receptor-2 (HER2)-overexpressing breast cancer cells. Furthermore, a derivative of the microtubule-targeting drug maytansine (DM1) was incorporated in the PGNSs. Methods Prepared PGNSs were coated with mPEG, DM1 and HER via electrostatic interactions and Au–S bonds to yield DM1-mPEG/HER-PGNSs. SK-BR-3 (high HER2 expression) and MCF-7 (low HER2) breast cancer cells were treated with DM1-mPEG/HER-PGNSs, and cytotoxicity was evaluated in terms of cell viability and apoptosis. The selective uptake of the coated PGNSs by cancer cells and subsequent intracellular accumulation were studied in vitro and in vivo using inductively coupled plasma mass spectrometry and fluorescence imaging. The multimodal imaging feasibility and synergistic chemo-photothermal therapeutic efficacy of the DM1-mPEG/HER-PGNSs were investigated in breast cancer tumour-bearing mice. The molecular mechanisms associated with the anti-tumour therapeutic use of the nanoparticles were also elucidated. Result The prepared DM1-mPEG/HER-PGNSs had a size of 78.6 nm and displayed excellent colloidal stability, photothermal conversion ability and redox-sensitive drug release. These DM1-mPEG/HER-PGNSs were taken up selectively by cancer cells in vitro and accumulated at tumour sites in vivo. Moreover, the DM1-mPEG/HER-PGNSs enhanced the performance of multimodal computed tomography (CT), photoacoustic (PA) and photothermal (PT) imaging and enabled chemo-thermal combination therapy. The therapeutic mechanism involved the induction of tumour cell apoptosis via the activation of tubulin, caspase-3 and the heat shock protein 70 pathway. M2 macrophage suppression and anti-metastatic functions were also observed. Conclusion The prepared DM1-mPEG/HER-PGNSs enabled nanodart-like tumour targeting, visibility by CT, PA and PT imaging in vivo and powerful tumour inhibition mediated by chemo-thermal combination therapy in vivo. In summary, these unique gold nanocarriers appear to have good potential as theranostic nanoagents that can serve both as a probe for enhanced multimodal imaging and as a novel targeted anti-tumour drug delivery system to achieve precision nanomedicine for cancers.

A polydopamine-coated LAPONITE®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy

2019 ◽  
Vol 7 (24) ◽  
pp. 3856-3864 ◽  
Author(s):  
Mengxue Liu ◽  
Jiulong Zhang ◽  
Xin Li ◽  
Chao Cai ◽  
Xueyan Cao ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Sialic Acid ◽  
Magnetic Resonance ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Photoacoustic Imaging

A novel targeted theranostic nanoplatform (LAP–Fe3O4@PDA–PEG–PBA) is constructed for magnetic resonance and photoacoustic imaging-guided photothermal therapy of cancer cells overexpressing sialic acid.

Sign in / Sign up

Export Citation Format

Share Document