The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells

2012 ◽  
Vol 22 (2) ◽  
pp. 660-665 ◽  
Author(s):  
Lyudmila Turyanska ◽  
Tracey D. Bradshaw ◽  
Mei Li ◽  
Philip Bardelang ◽  
William C. Drewe ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Differential Effect ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Cancerous Cells

scholarly journals Differential Effect of Jasmonic Acid and Abscisic Acid on Cell Cycle Progression in Tobacco BY-2 Cells

2002 ◽  
Vol 128 (1) ◽  
pp. 201-211 ◽  
Author(s):  
Agnieszka Świa̧tek ◽  
Marc Lenjou ◽  
Dirk Van Bockstaele ◽  
Dirk Inzé ◽  
Harry Van Onckelen
Keyword(s):  
Cell Cycle ◽  
Abscisic Acid ◽  
Jasmonic Acid ◽  
Differential Effect ◽  
Cell Cycle Progression ◽  
Cycle Progression

scholarly journals Differential Effect of Rac and Cdc42 on p38 Kinase Activity and Cell Cycle Progression of Nonadherent Primary Mouse Fibroblasts

2000 ◽  
Vol 275 (8) ◽  
pp. 5911-5917 ◽  
Author(s):  
Alexandre Philips ◽  
Pierre Roux ◽  
Vincent Coulon ◽  
Jean-Michel Bellanger ◽  
Annick Vié ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Differential Effect ◽  
Cell Cycle Progression ◽  
Kinase Activity ◽  
P38 Kinase ◽  
Cycle Progression ◽  
Mouse Fibroblasts ◽  
Primary Mouse

scholarly journals Design of Amino Acid- and Carbohydrate-Based Anticancer Drugs to Inhibit PIM kinases, an In Silico Study

2021 ◽  
Author(s):  
Sepideh Kalhor ◽  
Alireza Fattahi
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
The Novel ◽  
Serine Threonine Kinase ◽  
Cycle Progression ◽  
Threonine Kinase ◽  
Pim Kinases ◽  
In Silico Study ◽  
Regulation Of Cell Cycle ◽  
Cancerous Cells

PIM-1 is a serine-threonine kinase which is mainly expressed in tissues such as Thymus, spleen, bone marrow, and liver. This protein takes a role in many stages of the cell cycle, including the regulation of cell cycle progression and apoptosis. According to many studies, overexpression of PIM kinases happens in various types of human tumors; such as lymphomas, prostate cancer, and oral cancer. As a result, the design of drugs to inhibit PIM-1 in cancerous cells has attracted many attentions in recent years. This study aimed to design the alternative inhibitors for PIM-1 kinase, which are based on carbohydrates and amino acids and are expected to be non-toxic and to have the same chemotherapeutic effects as the traditional agents. The combinatorial use of quantum mechanics studies and molecular dynamic simulation (MD) has enabled us to precisely predict the mechanism of the inhibition of PIM-1 kinase by the novel designed drugs and to compare them with the recently synthesized chemotherapeutic drugs; such as DBC.

Effects of Galbanic Acid on Proliferation, Migration, and Apoptosis of Glioblastoma Cells Through the PI3K/Akt/MTOR Signaling Pathway

2020 ◽  
Vol 14 (1) ◽  
pp. 79-87
Author(s):  
Seyed H. Shahcheraghi ◽  
Marzieh Lotfi ◽  
Mohammad Soukhtanloo ◽  
Majid Ghayour Mobarhan ◽  
Hossein Z. Jaliani ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Migration ◽  
Cell Cycle Progression ◽  
Gelatin Zymography ◽  
Glioblastoma Cells ◽  
Cycle Progression ◽  
Scratch Assay ◽  
Expression Of Genes ◽  
Cancerous Cells ◽  
Galbanic Acid

Background: Glioblastoma is one of the most aggressive tumors of central nervous system. Galbanic acid, a natural sesquiterpene coumarin, has shown favorable effects on cancerous cells in previous studies. Objective: The aim of the present work was to evaluate the effects of galbanic acid on proliferation, migration, and apoptosis of the human malignant glioblastoma (U87) cells. Methods: Anti-proliferative activity of the compound was determined by MTT assay. Cell cycle alterations and apoptosis were analyzed via flow cytometry. Action on cell migration was evaluated by scratch assay and gelatin zymography. Quantitative Real-Time PCR was used to determine the expression of genes involved in cell migration (matrix metalloproteinases, MMPs) and survival (the pathways of PI3K/Akt/mTOR and WNT/β-catenin). Alteration in the level of protein Akt was determined by Western blotting. Results: Galbanic acid significantly decreased cell proliferation, inhibited cell cycle, and stimulated apoptosis of the glioblastoma cells. Also, it could decrease migration capability of glioblastoma cells, which was accompanied by an inhibition in the activity and expression of MMP2 and MMP9. While galbanic acid reduced the gene expression of Akt, mTOR, and PI3K and increased the PTEN expression, it had no significant effect on WNT, β-catenin, and APC genes. Also, the protein level of p-Akt decreased after treatment with galbanic acid. The effects of galbanic acid were observed at concentrations lower than those of temozolomide. Conclusion: Galbanic acid decreased proliferation, cell cycle progression, and survival of glioblastoma cells through inhibiting PI3K/Akt/mTOR pathway. This compound also reduced migration capability of the cells by suppressing the activity and expression of MMPs.

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