Facile route to functionalized mesoporous silica nanoparticles by click chemistry

2011 ◽  
Vol 21 (35) ◽  
pp. 13476 ◽  
Author(s):  
Nirmalya Moitra ◽  
Philippe Trens ◽  
Laurence Raehm ◽  
Jean-Olivier Durand ◽  
Xavier Cattoën ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Click Chemistry ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica ◽  
Facile Route

Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (39) ◽  
pp. 30640-30646 ◽  
Author(s):  
Yue Yan ◽  
Jie Fu ◽  
Xin Liu ◽  
Tianfu Wang ◽  
Xiuyang Lu
Keyword(s):  
Mesoporous Silica ◽  
Click Chemistry ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Functionalized Mesoporous Silica ◽  
Doxorubicin Release

An intracellular acidity-triggered doxorubicin release from “click chemistry” functionalized mesoporous silica nanoparticle was demonstrated.

Curcumin-Loaded Amine-Functionalized Mesoporous Silica Nanoparticles Inhibit α-Synuclein Fibrillation and Reduce Its Cytotoxicity-Associated Effects

Langmuir ◽  
2016 ◽  
Vol 32 (50) ◽  
pp. 13394-13402 ◽  
Author(s):  
Nayere Taebnia ◽  
Dina Morshedi ◽  
Soheila Yaghmaei ◽  
Farhang Aliakbari ◽  
Fatemeh Rahimi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized

scholarly journals Isolation and Quantification of miRNA from the Biomolecular Corona on Mesoporous Silica Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1196
Author(s):  
Carla Vidaurre-Agut ◽  
Eva María Rivero-Buceta ◽  
Christopher C. Landry ◽  
Pablo Botella
Keyword(s):  
Prostate Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Incubation Temperature ◽  
Mesoporous Silica Nanoparticles ◽  
Nanoparticle Concentration ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized ◽  
Commercial Kit ◽  
Higher Sensitivity

To understand the factors that control the formation of the biomolecular corona, a systematic study of the adsorption of several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica nanoparticles (MSN-NH2) has been performed. Process parameters including miRNA type, nanoparticle concentration, incubation temperature and incubation time were investigated, as well as the potential competition for adsorption between different miRNA molecules. The influence of proteins and particle PEGylation on miRNA adsorption were also explored. We found that low particle concentrations and physiological temperature both led to increased miRNA adsorption. Adsorption of miRNA was also higher when proteins were present in the same solution; reducing or preventing protein adsorption by PEGylating the MSNs hindered adsorption. Finally, the amount of miRNA adsorbed from human serum by MSN-NH2 was compared to a commercial miRNA purification kit (TaqMan®, Life Technologies, Carlsbad, CA, USA). MSN-NH2 adsorbed six times as much miRNA as the commercial kit, demonstrating higher sensitivity to subtle up- and downregulation of circulating miRNA in the blood of patients.

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