Ruthenium–alkylidene catalysed cross-metathesis of fatty acid derivatives with acrylonitrile and methyl acrylate: a key step toward long-chain bifunctional and amino acid compounds

2011 ◽  
Vol 13 (10) ◽  
pp. 2911 ◽  
Author(s):  
X. Miao ◽  
R. Malacea ◽  
C. Fischmeister ◽  
C. Bruneau ◽  
P. H. Dixneuf
Keyword(s):  
Fatty Acid ◽  
Amino Acid ◽  
Methyl Acrylate ◽  
Cross Metathesis ◽  
Fatty Acid Derivatives ◽  
Long Chain

Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer’s agent

2014 ◽  
Vol 24 (2) ◽  
pp. 604-608 ◽  
Author(s):  
Hong-Yan Zhang ◽  
Yu-ichiro Yamakawa ◽  
Yuji Matsuya ◽  
Naoki Toyooka ◽  
Chihiro Tohda ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Fatty Acid Derivatives ◽  
Long Chain

scholarly journals Electrospray Tandem Mass Spectrometry for Analysis of Acylcarnitines in Dried Postmortem Blood Specimens Collected at Autopsy from Infants with Unexplained Cause of Death

2001 ◽  
Vol 47 (7) ◽  
pp. 1166-1182 ◽  
Author(s):  
Donald H Chace ◽  
James C DiPerna ◽  
Brenda L Mitchell ◽  
Bethany Sgroi ◽  
Lindsay F Hofman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fatty Acid ◽  
Amino Acid ◽  
Tandem Mass Spectrometry ◽  
Metabolic Disorders ◽  
Tandem Mass ◽  
Postmortem Blood ◽  
Blood Specimens ◽  
Medical Examiners ◽  
Long Chain

Abstract Background: Deaths from inherited metabolic disorders may remain undiagnosed after postmortem examination and may be classified as sudden infant death syndrome. Tandem mass spectrometry (MS/MS) may reveal disorders of fatty acid oxidation in deaths of previously unknown cause. Methods: We obtained filter-paper blood from 7058 infants from United States and Canadian Medical Examiners. Acylcarnitine and amino acid profiles were obtained by MS/MS. Specialized interpretation was used to evaluate profiles for disorders of fatty acid, organic acid, and amino acid metabolism. The analyses of postmortem blood specimens were compared with the analyses of bile specimens, newborn blood specimens, and specimens obtained from older infants at risk for metabolic disorders. Results: Results on 66 specimens suggested diagnoses of metabolic disorders. The most frequently detected disorders were medium-chain and very-long-chain acyl-CoA dehydrogenase deficiencies (23 and 9 cases, respectively), glutaric acidemia type I and II deficiencies (3 and 8 cases, respectively), carnitine palmitoyl transferase type II/translocase deficiencies (6 cases), severe carnitine deficiency (4 cases), isovaleric acidemia/2-methylbutyryl-CoA dehydrogenase deficiencies (4 cases), and long-chain hydroxyacyl-CoA dehydrogenase/trifunctional protein deficiencies (4 cases). Conclusions: Postmortem metabolic screening can explain deaths in infants and children and provide estimates of the number of infant deaths attributable to inborn errors of metabolism. MS/MS is cost-effective for analysis of postmortem specimens and should be considered for routine use by Medical Examiners and pathologists in unexpected/unknown infant and child death.

scholarly journals Cover Picture: Cross-Metathesis of Biosourced Fatty Acid Derivatives: A Step Further Toward Improved Reactivity (ChemSusChem 7/2015)

ChemSusChem ◽  
2015 ◽  
Vol 8 (7) ◽  
pp. 1097-1097
Author(s):  
Paul Vignon ◽  
Tom Vancompernolle ◽  
Jean-Luc Couturier ◽  
Jean-Luc Dubois ◽  
André Mortreux ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cross Metathesis ◽  
Fatty Acid Derivatives
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