Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkyl Grignard reagents or arylboronic acids

2011 ◽  
Vol 1 (7) ◽  
pp. 1149 ◽  
Author(s):  
Manabu Hatano ◽  
Riku Gouzu ◽  
Tomokazu Mizuno ◽  
Hitoshi Abe ◽  
Toshihide Yamada ◽  
...  
Keyword(s):  
Grignard Reagents ◽  
Arylboronic Acids ◽  
Aldehydes And Ketones ◽  
Organozinc Reagents

Synthesis of allyl-aziridines from α-halo oxime ethers and allyl zinc bromides

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 26437-26440 ◽  
Author(s):  
Songlin Zheng ◽  
Songlin Zhang
Keyword(s):  
Grignard Reagents ◽  
Mild Conditions ◽  
Novel Method ◽  
Organozinc Reagents

A novel method for the preparation of allyl aziridines by reacting α-halo oxime ethers with allylic zinc reagents under mild conditions. Some advantages of using organozinc reagents are that they are easily prepared, non-toxic, and more selective than Grignard reagents.

Recent Advances in the Synthesis of Enantiomerically Enriched Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols through Addition of Organometallic Reagents to Carbonyl Compounds

Synthesis ◽  
2020 ◽  
Vol 52 (13) ◽  
pp. 1855-1873
Author(s):  
Senthil Narayanaperumal ◽  
Ricardo S. Schwab ◽  
Wystan K. O. Teixeira ◽  
Danilo Yano de Albuquerque
Keyword(s):  
Carbonyl Compounds ◽  
Building Blocks ◽  
Short Review ◽  
Biological Properties ◽  
Enantioselective Synthesis ◽  
Grignard Reagents ◽  
Organometallic Reagents ◽  
Important Family ◽  
Organolithium Reagents ◽  
Organozinc Reagents

Enantiomerically enriched diaryl, aryl heteroaryl, and dihetero­aryl alcohols are an important family of compounds known for their biological properties. Moreover, these molecules are highly privileged scaffolds used as building blocks for the synthesis of pharmaceutically relevant products. This short review provides background on the enantioselective arylation and heteroarylation of carbonyl compounds, as well as, the most significant improvements in this field with special emphasis on the application of organometallic reagents.1 Introduction2 Background on the Enantioselective Synthesis of Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols3 Organozinc Reagents4 Organolithium Reagents5 Grignard Reagents6 Organoaluminum Reagents7 Organotitanium Reagents8 Organobismuth Reagents9 Miscellaneous10 Conclusion

Reactions of .alpha.,.beta.-epoxysilanes with Grignard reagents. Generation and trapping of .alpha.-trimethylsilyl aldehydes and ketones

1980 ◽  
Vol 45 (22) ◽  
pp. 4444-4448 ◽  
Author(s):  
Paul F. Hudrlik ◽  
Anne M. Hudrlik ◽  
Raj N. Misra ◽  
David Peterson ◽  
Gregory P. Withers ◽  
...  
Keyword(s):  
Grignard Reagents ◽  
Aldehydes And Ketones ◽  
Alpha Beta

ChemInform Abstract: The Rhodium-Catalyzed 1,2-Addition of Arylboronic Acids to Aldehydes and Ketones with Sulfonated S-Phos.

ChemInform ◽  
2010 ◽  
Vol 41 (14) ◽  
Author(s):  
James R. White ◽  
Gareth J. Price ◽  
Pawel K. Plucinski ◽  
Christopher G Frost
Keyword(s):  
Arylboronic Acids ◽  
Aldehydes And Ketones

ChemInform Abstract: Aminomethylation of Functionalized Organozinc Reagents and Grignard Reagents Using Immonium Trifluoroacetates.

ChemInform ◽  
2000 ◽  
Vol 31 (41) ◽  
pp. no-no
Author(s):  
Nicolas Millot ◽  
Claudia Piazza ◽  
Salvatore Avolio ◽  
Paul Knochel
Keyword(s):  
Grignard Reagents ◽  
Organozinc Reagents
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