Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents

2012 ◽  
Vol 41 (7) ◽  
pp. 2575-2589 ◽  
Author(s):  
Nohyun Lee ◽  
Taeghwan Hyeon
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Contrast ◽  
Designed Synthesis

scholarly journals Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

Inorganics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 28 ◽  
Author(s):  
Irene Fernández-Barahona ◽  
María Muñoz-Hernando ◽  
Jesus Ruiz-Cabello ◽  
Fernando Herranz ◽  
Juan Pellico
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Positive Contrast ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
The Past ◽  
T1 Contrast

Iron oxide nanoparticles have been extensively utilised as negative (T2) contrast agents in magnetic resonance imaging. In the past few years, researchers have also exploited their application as positive (T1) contrast agents to overcome the limitation of traditional Gd3+ contrast agents. To provide T1 contrast, these particles must present certain physicochemical properties with control over the size, morphology and surface of the particles. In this review, we summarise the reported T1 iron oxide nanoparticles and critically revise their properties, synthetic protocols and application, not only in MRI but also in multimodal imaging. In addition, we briefly summarise the most important nanoparticulate Gd and Mn agents to evaluate whether T1 iron oxide nanoparticles can reach Gd/Mn contrast capabilities.

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