Helix-helix interactions – homochirality and heterochirality

CrystEngComm ◽  
2011 ◽  
Vol 13 (24) ◽  
pp. 7207 ◽  
Author(s):  
Artur R. Stefankiewicz ◽  
André De Cian ◽  
Jack Harrowfield
Keyword(s):  
Helix Interactions

Specificity and promiscuity in membrane helix interactions

1994 ◽  
Vol 27 (2) ◽  
pp. 157-218 ◽  
Author(s):  
Mark A. Lemmon ◽  
Donald M. Engelman
Keyword(s):  
Membrane Proteins ◽  
Transmembrane Helix ◽  
Integral Membrane Proteins ◽  
Lipid Packing ◽  
Membrane Protein Folding ◽  
Membrane Spanning ◽  
Α Helix ◽  
Prosthetic Groups ◽  
Packing Effects ◽  
Helix Interactions

The membrane-spanning portions of many integral membrane proteins consist of one or a number of transmembrane α-helices, which are expected to be independently stable on thermodynamic grounds. Side-by-side interactions between these transmembrane α-helices are important in the folding and assembly of such integral membrane proteins and their complexes. In considering the contribution of these helix–helix interactions to membrane protein folding and oligomerization, a distinction between the energetics and specificity should be recognized. A number of contributions to the energetics of transmembrane helix association within the lipid bilayer will be relatively non-specific, including those resulting from charge–charge interactions and lipid–packing effects. Specificity (and part of the energy) in transmembrane α-helix association, however, appears to rely mainly upon a detailed stereochemical fit between sets of dynamically accessible states of particular helices. In some cases, these interactions are mediated in part by prosthetic groups.

Modulating Transmembrane α-Helix Interactions through pH-Sensitive Boundary Residues

Biochemistry ◽  
2016 ◽  
Vol 55 (31) ◽  
pp. 4306-4315 ◽  
Author(s):  
Derek P. Ng ◽  
Charles M. Deber
Keyword(s):  
Ph Sensitive ◽  
Α Helix ◽  
Helix Interactions

Transmembrane α-Helix Interactions are Required for the Functional Assembly of theEscherichia coliTol Complex

1995 ◽  
Vol 246 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Jean Claude Lazzaroni ◽  
Anne Vianney ◽  
Jean Luc Popot ◽  
Hélène Bénédetti ◽  
Fadel Samatey ◽  
...  
Keyword(s):  
Α Helix ◽  
Helix Interactions

Lipid Solvation Effects Contribute to the Affinity of Gly-xxx-Gly Motif-Mediated Helix−Helix Interactions†

Biochemistry ◽  
2006 ◽  
Vol 45 (28) ◽  
pp. 8507-8515 ◽  
Author(s):  
Rachel M. Johnson ◽  
Arianna Rath ◽  
Roman A. Melnyk ◽  
Charles M. Deber
Keyword(s):  
Solvation Effects ◽  
Helix Interactions

scholarly journals The N-terminal Sequence Affects Distant Helix Interactions in Hemoglobin

1998 ◽  
Vol 273 (52) ◽  
pp. 35032-35038 ◽  
Author(s):  
Antoine Dumoulin ◽  
Júlio César Padovan ◽  
Lois R. Manning ◽  
Anthony Popowicz ◽  
Robert M. Winslow ◽  
...  
Keyword(s):  
Terminal Sequence ◽  
Helix Interactions
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