Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

2012 ◽  
Vol 48 (6) ◽  
pp. 847-849 ◽  
Author(s):  
Jenny Z. Zhang ◽  
Ezequiel Wexselblatt ◽  
Trevor W. Hambley ◽  
Dan Gibson
Keyword(s):  
Electrochemical Reduction ◽  
Reduction Potential

Réduction catalytique de cétones α,β-éthyléniques à température modérée par

1979 ◽  
Vol 57 (2) ◽  
pp. 218-221 ◽  
Author(s):  
D. Beaupere ◽  
P. Bauer ◽  
R. Uzan
Keyword(s):  
Electrochemical Reduction ◽  
Reduction Potential ◽  
Initial Rate ◽  
Substituent Effects ◽  
Hydrogenation Reaction ◽  
Unsaturated Ketones ◽  
Hydride Ion ◽  
Inverse Effect ◽  
Electron Donating Groups

The use of the catalyst [Formula: see text] in the reduction of the ethylenic system of styryl ketones by 1-phenylethanol permits the hydrogenation reaction to proceed at 50 °C. Some substituent effects in the α,β-unsaturated ketones were demonstrated at this temperature. These showed an increase in the initial rate of reduction for electron-attracting groups and the inverse effect for electron-donating groups. The observation of a relation between the electrochemical reduction potential of these ketones and their rate of hydrogenation suggests a transfer of hydrogen to the ketone by a hydride ion intermediate. [Journal translation]

Diammonium Salts Derived From 1,4-Diazabicyclo[2.2.2]octane

1994 ◽  
Vol 47 (1) ◽  
pp. 7 ◽  
Author(s):  
A Bayada ◽  
GA Lawrance ◽  
M Maeder
Keyword(s):  
Aqueous Solution ◽  
Electrochemical Reduction ◽  
Functional Group ◽  
Reduction Potential ◽  
Hofmann Elimination

The syntheses of a range of quaternary diammonium and some monoammonium salts derived from 1,4-diazabicyclo[2.2.2]octane with N-alkyl arms or N-alkyl arms terminated by a functional group are reported. In aqueous solution they are susceptible to only very slow Hofmann elimination, and the kinetics were investigated for the 1-(2′-ammonioethyl)-4-dodecyl-1,4-diazoniabicyclo[2.2.2]octane ion, which undergoes a base-induced elimination ( kOH 6.9×10-4 dm3 mol-1 s-1 at 55°C) consistent with an ElcB mechanism. In aqueous solution, the diammonium cations are not oxidized but undergo irreversible electrochemical reduction below -1.2 V v . Ag/ AgCl , with the reduction potential apparently influenced by the electron-withdrawing or -donating nature of substituent arms.

scholarly journals Redox properties and prooxidant cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX).

2013 ◽  
Vol 60 (2) ◽  
Author(s):  
Jonas Šarlauskas ◽  
Aušra Nemeikaitė-Čėnienė ◽  
Lina Misevičienė ◽  
Kastis Krikštopaitis ◽  
Žilvinas Anusevičius ◽  
...  
Keyword(s):  
Electrochemical Reduction ◽  
Bovine Leukemia Virus ◽  
Reduction Potential ◽  
Leukemia Virus ◽  
Redox Properties ◽  
Single Electron ◽  
Reduction Peak ◽  
Neuroleptic Agent ◽  
Electron Reduction ◽  
Dt Diaphorase

In order to characterize the possible mechanism(s) of cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX) we examined the redox properties of DNQX, and its mononitro- (NQX) and denitro- (QX) derivatives. The irreversible electrochemical reduction of the nitro groups of DNQX was characterized by the reduction peak potentials (Ep,7) of -0.43 V and -0.72 V vs. Ag/AgCl at pH 7.0, whereas NQX was reduced at Ep,7 = -0.67 V. The reactivities of DNQX and NQX towards the single-electron transferring enzymes NADPH:cytochrome P-450 reductase and NADPH:adrenodoxin reductase/adrenodoxin complex were similar to those of model nitrobenzenes with the single-electron reduction potential (E¹₇) values of -0.29 V - -0.42 V. DNQX and NQX also acted as substrates for two-electron transferring mammalian NAD(P)H:quinone oxidoreductase (DT-diaphorase). The cytotoxicity of DNQX in bovine leukemia virus-transformed lamb kidney fibroblasts (line FLK) was prevented by antioxidants and an inhibitor of NQO1, dicoumarol, and was enhanced by the prooxidant alkylating agent 1,3-bis(2-chloromethyl)-1-nitrosourea. A comparison with model nitrobenzene compounds shows that the cytotoxicity of DNQX and NQX reasonably agrees with the ease of their electrochemical reduction, and/or their reactivities towards the used enzymatic single-electron reducing systems. Thus, our data imply that the cytotoxicity of DNQX in FLK cells is exerted mainly through oxidative stress.

scholarly journals Synthesis, spectroscopic studies and electrochemical properties of Schiff bases derived from 2-hydroxyaldehydes and phenazopyridine hydrochloride

2013 ◽  
Vol 78 (6) ◽  
pp. 795-804 ◽  
Author(s):  
Sultan Yagmur ◽  
Selehattin Yilmaz ◽  
Gulsen Saglikoglu ◽  
Murat Sadikoglu ◽  
Mustafa Yildiz ◽  
...  
Keyword(s):  
Electrochemical Properties ◽  
Electrochemical Reduction ◽  
Schiff Bases ◽  
Glassy Carbon ◽  
Reduction Potential ◽  
Spectroscopic Studies ◽  
Spectroscopic Techniques ◽  
Carbon Electrode ◽  
Reduction Mechanism ◽  
Cyclic Voltammetric

Novel Schiff bases (1-4) were synthesized by the reaction of 2-hydroxybenzaldehyde, 2-hydroxy-5-methoxybenzaldehyde, 2-hydroxy-5-nitrobenzaldehyde, 2-hydroxy-1-naptaldehyde with phenazopypridine hydrochloride (PAP) and their structures were elucidated by means of spectroscopic techniques. The electrochemical reduction of PAP and its Schiff bases (1-4) were carried out on glassy carbon electrode (GCE) in dimethyl sulfoxide (DMSO) using the cyclic voltammetric (CV) technique. The effect of functional groups on reduction potential of Schiff bases was investigated. A general electrochemical reduction mechanism of the compounds was also suggested.

scholarly journals Controlled decomposition of SF6 by electrochemical reduction

2020 ◽  
Vol 16 ◽  
pp. 2948-2953
Author(s):  
Sébastien Bouvet ◽  
Bruce Pégot ◽  
Stéphane Sengmany ◽  
Erwan Le Gall ◽  
Eric Léonel ◽  
...  
Keyword(s):  
Ambient Temperature ◽  
Electrochemical Reduction ◽  
Sulfur Hexafluoride ◽  
Reduction Potential ◽  
Environmentally Benign ◽  
Fluoride Anion ◽  
Electrical Detection ◽  
Exact Number

The electroreduction of SF6 is shown at ambient temperature in acetonitrile using an array of platinum microelectrodes to improve the electrical detection. Its half reduction potential occurs at −2.17 V vs Fc+/Fc. The exact number of electrons for the full consumption of sulfur hexafluoride was determined and this gas further quantitatively transformed into environmentally benign fluoride anion and sulfur by electrochemical reduction.

Réduction électrochimique de cétones aromatiques encombrées en milieu aprotique et en présence de chlorure de manganèse

1983 ◽  
Vol 61 (9) ◽  
pp. 2121-2125 ◽  
Author(s):  
Françoise Fournier ◽  
Jacques Berthelot ◽  
Yves-Louis Pascal
Keyword(s):  
Electrochemical Reduction ◽  
Electrode Surface ◽  
Reduction Potential ◽  
Aromatic Ketones ◽  
Aprotic Medium ◽  
Total Lack

The electrochemical reduction of hindered aromatic ketones which are difficult to reduce can be achieved in an aprotic medium (DMF) on a mercury pool cathode, in presence of Mn(II) chloride, at the reduction potential of the Mn(II)/Mn(0) system, but less negative than that of the ketone itself. There is selective hydrodimerization into an α-glycol, with total lack of polymerization. With dissymmetric ketones, the dl diastereoisomers of the diols are produced preferentially. The effect of manganese is due either to the reduction of a Mn(I) or Mn(0) – ketone complex or to the reduction of the ketone by a film of colloidal manganese on the electrode surface.

Sign in / Sign up

Export Citation Format

Share Document