Vanadium bromoperoxidase from Delisea pulchra: enzyme-catalyzed formation of bromofuranone and attendant disruption of quorum sensing

Moriah Sandy; Jayme N. Carter-Franklin; Jessica D. Martin; Alison Butler

doi:10.1039/c1cc15605e

Vanadium bromoperoxidase from Delisea pulchra: enzyme-catalyzed formation of bromofuranone and attendant disruption of quorum sensing

Chemical Communications ◽

10.1039/c1cc15605e ◽

2011 ◽

Vol 47 (44) ◽

pp. 12086 ◽

Cited By ~ 34

Author(s):

Moriah Sandy ◽

Jayme N. Carter-Franklin ◽

Jessica D. Martin ◽

Alison Butler

Keyword(s):

Quorum Sensing ◽

Delisea Pulchra

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Bioactive compound that inhabit quorum sensing system in gram negative bacteria

Biofarmasi Journal of Natural Product Biochemistry ◽

10.13057/biofar/f040107 ◽

2006 ◽

Vol 4 (1) ◽

pp. 34-40

Author(s):

NUR AINI ◽

AHMAD DWI SETYAWAN

Keyword(s):

Quorum Sensing ◽

Bioactive Compound ◽

Homoserine Lactone ◽

Cell Number ◽

Gram Negative Bacteria ◽

Gram Negative ◽

Sensing System ◽

Delisea Pulchra ◽

Novel Target ◽

Flustra Foliacea

Bacteria communicate using chemical signaling molecules as words. They release, detect, and respond to the accumulation of these molecules, which are called autoinducers. Detection of autoinducers allows bacteria to distinguish between low and high cell population density, and to control gene expression in response to changes the cell number. This process is termed quorum sensing. Many bacterial behaviors are regulated by quorum sensing, including virulence factors on gram negative bacteria. Quorum sensing is a novel target for antimicrobial therapies. Many eukariots including plants, fungus, and animals produce molecules that can interfered bacteria communication, such as halogen furanon from alga Delisea pulchra, N- (heptylsulfanylacetyl)-L-homoserine-lactone from Allium sativum, and flustramine from bryozoan Flustra foliacea.

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Structure–activity relationships of furanones, dihydropyrrolones and thiophenones as potential quorum sensing inhibitors

Future Medicinal Chemistry ◽

10.4155/fmc-2020-0244 ◽

2020 ◽

Vol 12 (21) ◽

pp. 1925-1943

Author(s):

Thérèse Lyons ◽

Cormac GM Gahan ◽

Timothy P O'Sullivan

Keyword(s):

Quorum Sensing ◽

Antimicrobial Agents ◽

Molecular Response ◽

Bacterial Strains ◽

Structure Activity Relationships ◽

Quorum Sensing Inhibitors ◽

Structure Activity ◽

Main Ring ◽

Delisea Pulchra ◽

Potential Inhibitors

Since their initial isolation from the marine alga Delisea pulchra, bromofuranones have been investigated as potential inhibitors of quorum sensing (QS) in various bacterial strains. QS is an important mechanism by which bacteria co-ordinate their molecular response to the environment. QS is intrinsically linked to bacterial antibiotic resistance. Inspired by nature, chemists have developed a wide variety of synthetic analogs in an effort to elucidate the structure–activity relationships of these compounds, and to ultimately develop novel antimicrobial agents. In this work, we describe advances in this field while paying particular attention to apparent structure–activity relationships. This review is organized according to the main ring systems under investigation, namely furanones, dihydropyrrolones and thiophenones.

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