Brief, efficient and highly diastereoselective synthesis of (±)-pumiliotoxin C based on the generation of an octahydroquinoline precursor via a four-component reaction

2011 ◽  
Vol 47 (38) ◽  
pp. 10554 ◽  
Author(s):  
Swarupananda Maiti ◽  
J. Carlos Menéndez
Keyword(s):  
Diastereoselective Synthesis ◽  
Pumiliotoxin C

Naturally Occurring Organic Acid-catalyzed Facile Diastereoselective Synthesis of Biologically Active (E)-3-(arylimino)indolin-2-one Derivatives in Water at Room Temperature

2019 ◽  
Vol 23 (16) ◽  
pp. 1778-1788 ◽  
Author(s):  
Gurpreet Kaur ◽  
Arvind Singh ◽  
Kiran Bala ◽  
Mamta Devi ◽  
Anjana Kumari ◽  
...  
Keyword(s):  
Room Temperature ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Diastereoselective Synthesis ◽  
Substituted Anilines ◽  
Reaction Conditions ◽  
Naturally Occurring ◽  
Acid Catalyzed ◽  
Reaction Media ◽  
Column Chromatographic

A simple, straightforward and efficient method has been developed for the synthesis of (E)-3-(arylimino)indolin-2-one derivatives and (E)-2-((4-methoxyphenyl)imino)- acenaphthylen-1(2H)-one. The synthesis of these biologically-significant scaffolds was achieved from the reactions of various substituted anilines and isatins or acenaphthaquinone, respectively, using commercially available, environmentally benign and naturally occurring organic acids such as mandelic acid or itaconic acid as catalyst in aqueous medium at room temperature. Mild reaction conditions, energy efficiency, good to excellent yields, environmentally benign conditions, easy isolation of products, no need of column chromatographic separation and the reusability of reaction media are some of the significant features of the present protocol.

Diastereoselective Synthesis of Novel Optically Active Five Membered O- and N-heterocyclic Compounds

2012 ◽  
Vol 9 (2) ◽  
pp. 81-88 ◽  
Author(s):  
Ervin Kovacs ◽  
Ferenc Farkas ◽  
Angelika Thurner ◽  
Aron Szollosy ◽  
Ferenc Faigl
Keyword(s):  
Heterocyclic Compounds ◽  
Optically Active ◽  
Diastereoselective Synthesis

ChemInform Abstract: Diastereoselective Synthesis of the Key Intermediate of the BO-2727 Side Chain.

ChemInform ◽  
2010 ◽  
Vol 29 (3) ◽  
pp. no-no
Author(s):  
N. OHTAKE ◽  
H. JONA ◽  
S. OKADA ◽  
O. OKAMOTO ◽  
Y. IMAI ◽  
...  
Keyword(s):  
Side Chain ◽  
Diastereoselective Synthesis

Biocatalytic approaches for enantio and diastereoselective synthesis of chiral β-nitroalcohols

2021 ◽  
Author(s):  
D. H. Sreenivasa Rao ◽  
Ayon Chatterjee ◽  
Santosh Kumar Padhi
Keyword(s):  
Bioactive Molecules ◽  
Diastereoselective Synthesis ◽  
Synthetic Intermediates

Chiral β-nitroalcohols are versatile synthetic intermediates for several pharmaceuticals, and bioactive molecules. This review describes the importance and various biocatalytic approaches for their enantio and diastereoselective synthesis.

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