Small-molecule fluorescent probes for specific RNA targets

2011 ◽  
Vol 47 (16) ◽  
pp. 4712 ◽  
Author(s):  
Asako Murata ◽  
Shin-ichi Sato ◽  
Yoshinori Kawazoe ◽  
Motonari Uesugi
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Rna Targets

scholarly journals Small-molecule fluorescence-based probes for interrogating major organ diseases

2021 ◽  
Author(s):  
Hai-Hao Han ◽  
He Tian ◽  
Yi Zang ◽  
Adam C. Sedgwick ◽  
Jia Li ◽  
...  
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Recent Advances ◽  
Major Organ

This tutorial review describes recent advances involving small molecule fluorescent probes designed to aid in the study of major organ diseases.

Recent Development of Reactional Small-Molecule Fluorescent Probes Based on Resorufin

2021 ◽  
pp. 109351
Author(s):  
Han Wang ◽  
Huihui Su ◽  
Nannan Wang ◽  
Jiamin Wang ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes

Advances in the chemistry of small molecule fluorescent probes

2011 ◽  
Vol 15 (6) ◽  
pp. 752-759 ◽  
Author(s):  
Laura M Wysocki ◽  
Luke D Lavis
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes

scholarly journals Fluorescent Probes with Unnatural Amino Acids to Monitor Proteasome Activity in Real-Time

2020 ◽  
Author(s):  
Breanna L. Zerfas ◽  
Rachel A. Coleman ◽  
Andres Salazar Chaparro ◽  
Nathaniel J. Macatangay ◽  
Darci Trader
Keyword(s):  
Amino Acids ◽  
Small Molecule ◽  
Fluorescent Probes ◽  
Unnatural Amino Acids ◽  
Cell Types ◽  
Proteasome Activity ◽  
Live Cells ◽  
Fluorescent Substrate ◽  
The Individual ◽  
Small Molecule Modulators

<div> <div> <div> <p>The proteasome is an essential protein complex that, when dysregulated, can result in various diseases in eukaryotic cells. As such, understanding the enzymatic activity of the proteasome and what can alter it is crucial to elucidating its roles in these diseases. This can be done effectively by using activity-based fluorescent substrate probes, of which there are many commercially available that target the individual protease-like subunits in the 20S CP of the proteasome. Unfortunately, these probes have not displayed appropriate characteristics for their use in live cell-based assays. In the work presented here, we have developed a set of probes which have shown improved fluorescence properties and selectivity towards the proteasome compared to other cellular proteases. By including unnatural amino acids, we have found probes which can be utilized in various applications, including monitoring the effects of small molecule stimulators of the proteasome in live cells and comparing the relative proteasome activity across different cancer cell types. In future studies, we expect the fluorescent probes presented here will serve as tools to support the discovery and characterization of small molecule modulators of proteasome activity. </p> </div> </div> </div>

Small Molecule Fluorescent Probes for Sensing and Bioimaging of Nitroreductase

2022 ◽  
Vol 7 (1) ◽  
Author(s):  
Samarpita Das ◽  
Harish K. Indurthi ◽  
Pulkit Asati ◽  
Deepak K. Sharma
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes

Small Molecule as Fluorescent Probes for Monitoring Intracellular Enzymatic Transformations

2019 ◽  
Vol 119 (22) ◽  
pp. 11718-11760 ◽  
Author(s):  
Harwinder Singh ◽  
Karishma Tiwari ◽  
Rajeshwari Tiwari ◽  
Sumit Kumar Pramanik ◽  
Amitava Das
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes

Small molecule fluorescent probes of protein vicinal dithiols

2019 ◽  
Vol 30 (10) ◽  
pp. 1704-1716 ◽  
Author(s):  
Guodong Hu ◽  
Huiyi Jia ◽  
Lanning Zhao ◽  
Dong-Hyung Cho ◽  
Jianguo Fang
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Vicinal Dithiols

scholarly journals Correction to Small Molecule as Fluorescent Probes for Monitoring Intracellular Enzymatic Transformations

2020 ◽  
Vol 120 (9) ◽  
pp. 4254-4255 ◽  
Author(s):  
Harwinder Singh ◽  
Karishma Tiwari ◽  
Rajeshwari Tiwari ◽  
Sumit Kumar Pramanik ◽  
Amitava Das
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes
Sign in / Sign up

Export Citation Format

Share Document