Rapid analysis of abused drugs using nanostructured silicon surface assisted laser desorption/ionization mass spectrometry

The Analyst ◽  
2012 ◽  
Vol 137 (3) ◽  
pp. 654-661 ◽  
Author(s):  
Yu-Che Cheng ◽  
Kun-Han Chen ◽  
Juo-Shin Wang ◽  
Wen-Liu Hsu ◽  
Chih-Cheng Chien ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Silicon Surface ◽  
Laser Desorption ◽  
Rapid Analysis ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Nanostructured Silicon ◽  
Abused Drugs

Silicon surface assisted laser desorption ionization mass spectrometry for quantitative analysis

2021 ◽  
pp. 146906672110060
Author(s):  
Alexander A Grechnikov ◽  
Alexey S Borodkov ◽  
Yaroslav O Simanovsky ◽  
Sergey M Nikiforov
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Analysis ◽  
Silicon Substrate ◽  
Silicon Surface ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Surface Ionization ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization

The approach to quantitative analysis by silicon Surface Assisted Laser Desorption Ionization Mass Spectrometry (Si-SALDI) is proposed. The approach is based on the new method for forming an active surface layer on a silicon substrate by exposing to laser radiation directly in the ion source of a mass spectrometer. The method can be used repeatedly on the same substrate, providing high reproducibility of its surface ionization properties and high ionization efficiency of organic compounds. Within the proposed approach, the methods of improvement of signal reproducibility are also considered, including continuous monitoring of the silicon surface ionization properties using a Knudsen effusion cell; scanning the surface of a silicon substrate with a laser beam; selecting the optimal value of laser fluence and using a reproducible sample introduction technique. It is demonstrated that this approach can be successfully applied to quantify clinically relevant concentrations of pharmaceutical drugs in extracts of blood.

Surface-enhanced laser desorption/ionization mass spectrometry for rapid analysis of organic environmental pollutants by using polydopamine nanospheres as a substrate

The Analyst ◽  
2020 ◽  
Vol 145 (16) ◽  
pp. 5664-5669
Author(s):  
Kailong Luo ◽  
Baichuan Yang ◽  
Wenjing Guo ◽  
Qianqian Sun ◽  
Ouyang Dan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Environmental Pollutants ◽  
Laser Desorption ◽  
Rapid Analysis ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Surface Enhanced

Polydopamine nanospheres was designed to serve as a substrate for surface-enhanced desorption/ionization mass spectrometry, which showed superior LDI performance in the analysis of a variety of environmental pollutants.

Laser desorption ionization mass spectrometry of protein tryptic digests on nanostructured silicon plates

2012 ◽  
Vol 75 (7) ◽  
pp. 1973-1990 ◽  
Author(s):  
Mathieu Dupré ◽  
Yannick Coffinier ◽  
Rabah Boukherroub ◽  
Sonia Cantel ◽  
Jean Martinez ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Nanostructured Silicon
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