A new way to detect the interaction of DNA and anticancer drugs based on the decreased resonance light scattering signal and its potential application

The Analyst ◽  
2011 ◽  
Vol 136 (19) ◽  
pp. 3927 ◽  
Author(s):  
Zhanguang Chen ◽  
Tianhe Song ◽  
Yurui Peng ◽  
Xi Chen ◽  
Junhui Chen ◽  
...  
Keyword(s):  
Light Scattering ◽  
Anticancer Drugs ◽  
Potential Application ◽  
Resonance Light Scattering ◽  
Scattering Signal

An assay of DNA by resonance light scattering technique and its application in screening anticancer drugs

2012 ◽  
Vol 4 (6) ◽  
pp. 1546-1551 ◽  
Author(s):  
Xi Chen ◽  
Guoliang Liu ◽  
Shengwang Liang ◽  
Sihua Qian ◽  
Jinbin Liu ◽  
...  
Keyword(s):  
Light Scattering ◽  
Anticancer Drugs ◽  
Resonance Light Scattering ◽  
Scattering Technique ◽  
Resonance Light Scattering Technique ◽  
Light Scattering Technique

Spectroscopic studies of aggregation behavior of meso-tetra(4-hydroxyphenyl)porphyrin in aqueous AOT solution

2008 ◽  
Vol 12 (02) ◽  
pp. 101-108 ◽  
Author(s):  
Hongmin Ma ◽  
Shuting Sun ◽  
Xin Chen ◽  
Dan Wu ◽  
Peihua Zhu ◽  
...  
Keyword(s):  
Surface Tension ◽  
Light Scattering ◽  
Aqueous Solutions ◽  
Absorption Spectroscopy ◽  
Fluorescence Anisotropy ◽  
Soret Band ◽  
Spectroscopic Studies ◽  
Resonance Light Scattering ◽  
Scattering Signal ◽  
Resonance Light Scattering Technique

The interactions of two amphiphilic porphyrins with anionic surfactant sodium bis(2-ethylhexyl)sulfosuccinate (AOT) in aqueous solutions were studied by UV-vis absorption spectroscopy, fluorescence spectroscopy, resonance light scattering technique, fluorescence anisotropy and surface tension measurements. The two porphyrins, meso-tetra(4-hydroxyphenyl)porphyrin (THPP) and meso-tetra(3,5-dibromo-4-hydroxylphenyl)porphyrin (T(DBHP)P), exist as irregular aggregates in aqueous solutions with a broad and low absorption peak near the maximum of monomer peak. The interaction of THPP with AOT leads to the formation of a fluorescent aggregate of porphyrin which was assigned as J-type aggregate according to exciton theory. A long red-shifted Soret band together with a new strong Q-band, a broad emission peak and a sharply peaked resonance light scattering signal are observed for this J-aggregate. The formation of J-aggregate is independent of the initial THPP concentration and can be influenced greatly by ionic strength. The aggregation kinetics has been investigated by UV-vis absorption spectroscopy and fluorescence anisotropy. Conversion of the porphyrin monomers to J-aggregate is observed. The addition of THPP increases the surface tension of solution and changes the critical micelle concentration of AOT. J-aggregate was not observed for T(DBHP)P in AOT solutions which only shows solubilization. The mechanism of aggregation was discussed.

An Instrument-Based Screening Assay for DNA-Targeted Anticancer Drugs Using Resonance Light Scattering

2010 ◽  
Vol 13 (5) ◽  
pp. 383-392 ◽  
Author(s):  
Zhanguang Chen ◽  
Guoliang Liu ◽  
Maohuai Chen ◽  
Xi Chen ◽  
Mingyao Wu ◽  
...  
Keyword(s):  
Light Scattering ◽  
Anticancer Drugs ◽  
Resonance Light Scattering ◽  
Screening Assay

Selective and sensitive detection of lysozyme based on plasmon resonance light-scattering of hydrolyzed peptidoglycan stabilized-gold nanoparticles

The Analyst ◽  
2018 ◽  
Vol 143 (5) ◽  
pp. 1133-1140 ◽  
Author(s):  
Fei Fu ◽  
Linyao Li ◽  
Qingman Luo ◽  
Qingjin Li ◽  
Tingrui Guo ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Light Scattering ◽  
Plasmon Resonance ◽  
Resonance Light Scattering ◽  
Sensitive Detection ◽  
Scattering Signal

Simple, rapid, selective and sensitive detection of lysozyme based on plasmon resonance light scattering signal of hydrolyzed peptidoglycan stabilized-gold nanoparticles.

Correlation between light scattering signal and tissue reversibility in rat brain exposed to hypoxia

2010 ◽  
Author(s):  
Satoko Kawauchi ◽  
Shunichi Sato ◽  
Yoichi Uozumi ◽  
Hiroshi Nawashiro ◽  
Miya Ishihara ◽  
...  
Keyword(s):  
Light Scattering ◽  
Rat Brain ◽  
Scattering Signal
Sign in / Sign up

Export Citation Format

Share Document