Correlation between fibrin network structure and mechanical properties: an experimental and computational analysis

Soft Matter ◽  
2011 ◽  
Vol 7 (10) ◽  
pp. 4983 ◽  
Author(s):  
Eunjung Kim ◽  
Oleg V. Kim ◽  
Kellie R. Machlus ◽  
Xiaomin Liu ◽  
Timur Kupaev ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Network Structure ◽  
Computational Analysis ◽  
Fibrin Network ◽  
Fibrin Network Structure

scholarly journals Fibrin network structure and clot mechanical properties are altered by incorporation of erythrocytes

2009 ◽  
Vol 102 (12) ◽  
pp. 1169-1175 ◽  
Author(s):  
Kathryn Gersh ◽  
Chandrasekaran Nagaswami ◽  
John Weisel
Keyword(s):  
Mechanical Properties ◽  
Network Structure ◽  
Fibrin Clot ◽  
Scanning Electron Micrographs ◽  
Fiber Network ◽  
Fibrin Network ◽  
Clot Structure ◽  
Fibrin Network Structure

SummaryAlthough many in vitro fibrin studies are performed with plasma, in vivo clots and thrombi contain erythrocytes, or red blood cells (RBCs).To determine the effects of RBCs on fibrin clot structure and mechanical properties, we compared plasma clots without RBCs to those prepared with low (2 vol%), intermediate (5-10 vol%), or high (≥20 vol%) numbers of RBCs. By confocal microscopy, we found that low RBC concentrations had little effect on clot structure. Intermediate RBC concentrations caused heterogeneity in the fiber network with pockets of densely packed fibers alongside regions with few fibers. With high levels of RBCs, fibers arranged more uniformly but loosely around the cells. Scanning electron micrographs demonstrated an uneven distribution of RBCs throughout the clot and a significant increase in fiber diameter upon RBC incorporation. While permeability was not affected by RBC addition, at 20% or higher RBCs, the ratio of viscous modulus (G′′) to elastic modulus (G′) increased significantly over that of a clot without any RBCs. RBCs triggered variability in the fibrin network structure, individual fiber characteristics, and overall clot viscoelasticity compared to the absence of cells. These results are important for understanding in vivo clots and thrombi.

Foodstate vitamin C complex may beneficially affect haemostasis and fibrin network structure in hyperlipidaemic patients

2004 ◽  
Vol 15 (8) ◽  
pp. 677-685 ◽  
Author(s):  
Deirdr?? Loots ◽  
Welma Oosthuizen ◽  
Marlien Pieters ◽  
Christelle Spies ◽  
Hester H Vorster
Keyword(s):  
Vitamin C ◽  
Network Structure ◽  
Fibrin Network ◽  
C Complex ◽  
Fibrin Network Structure

scholarly journals Thyroid Dysfunction and Fibrin Network Structure: A Mechanism for Increased Thrombotic Risk in Hyperthyroid Individuals

2012 ◽  
Vol 97 (5) ◽  
pp. 1463-1473 ◽  
Author(s):  
J. M. W. Hooper ◽  
D. J. F. Stuijver ◽  
S. M. Orme ◽  
B. van Zaane ◽  
K. Hess ◽  
...  
Keyword(s):  
Network Structure ◽  
Thyroid Dysfunction ◽  
Thrombotic Risk ◽  
Fibrin Network ◽  
Fibrin Network Structure

scholarly journals High-Dose Aspirin Is Required to Influence Plasma Fibrin Network Structure in Patients With Type 1 Diabetes

Diabetes Care ◽  
2011 ◽  
Vol 35 (2) ◽  
pp. 404-408 ◽  
Author(s):  
S. Tehrani ◽  
A. Antovic ◽  
F. Mobarrez ◽  
K. Mageed ◽  
P.-E. Lins ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Network Structure ◽  
High Dose ◽  
Dose Aspirin ◽  
Fibrin Network ◽  
High Dose Aspirin ◽  
Fibrin Network Structure

31. Fibrin network structure and atherosclerosis: effect of lipids

1996 ◽  
Vol 10 ◽  
pp. 12
Author(s):  
C.H. Nair ◽  
E. Shats ◽  
J.D. Wilson ◽  
D.P. Dhall
Keyword(s):  
Network Structure ◽  
Fibrin Network ◽  
Fibrin Network Structure

scholarly journals Ex vivo addition of fibrinogen concentrate improves the fibrin network structure in plasma samples taken during liver transplantation

2015 ◽  
Vol 13 (12) ◽  
pp. 2192-2201 ◽  
Author(s):  
D. J. Groeneveld ◽  
J. Adelmeijer ◽  
G. C. G. Hugenholtz ◽  
R. A. S. Ariëns ◽  
R. J. Porte ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Network Structure ◽  
Ex Vivo ◽  
Plasma Samples ◽  
Fibrinogen Concentrate ◽  
Fibrin Network ◽  
Fibrin Network Structure
Sign in / Sign up

Export Citation Format

Share Document