Size control of hollow poly-allylamine hydrochloride/poly-sodium styrene sulfonate microcapsules using the bubble template method

Soft Matter ◽  
2011 ◽  
Vol 7 (5) ◽  
pp. 1897 ◽  
Author(s):  
Jay Jesus Molino Cornejo ◽  
Eitaro Matsuoka ◽  
Hirofumi Daiguji
Author(s):  
Jay J. Molino ◽  
Hirofumi Daiguji ◽  
Fumio Takemura

Biodegradable hollow poly-lactic acid (PLA) microcapsules and hollow polyelectrolyte microcapsules made of poly-allylamine hydrochloride (PAH) were synthesized by directly adsorbing these polymers to N2 (air) and CO2 microbubbles respectively, using the bubble template method. To manufacture PLA microcapsules, droplets of a solution of PLA in methylene chloride (CH2Cl2) were emulsified in water. Then by solvent diffusion, N2 microbubbles nucleated inside the droplets and PLA adsorbed to the bubble surface to form microcapsules. Likewise, for PAH microcapsules, when an aqueous solution of Na2CO3 including PAH is titrated with HCl, within a specific range 7.5 < pH < 9.0, colloidal PAH particles are formed and then adsorbs to the nucleated CO2 microbubbles. This yields to hollow PAH microcapsules. If the solution pH is outside this range, colloidal particles can no longer exist, thus no microcapsules can be synthesized. This document mainly focuses on size control of these two types of microcapsules.


RSC Advances ◽  
2016 ◽  
Vol 6 (17) ◽  
pp. 14421-14426 ◽  
Author(s):  
Ya Lu ◽  
Ming Li ◽  
Zihan Guo ◽  
Xiaoyang Guo

A retarder comprised of sodium styrene sulfonate, itaconic acid and hydroxyethyl methacrylate was synthesized by aqueous free radical copolymerization, which can be applied to a long cementing interval.


2020 ◽  
Vol 26 (7-8) ◽  
pp. 450-459 ◽  
Author(s):  
Jagadeesh K. Venkatesan ◽  
Céline Falentin-Daudré ◽  
Amélie Leroux ◽  
Véronique Migonney ◽  
Magali Cucchiarini

ACS Omega ◽  
2020 ◽  
Vol 5 (14) ◽  
pp. 8137-8145
Author(s):  
Céline Falentin-Daudré ◽  
Mounia Aitouakli ◽  
Jean Sébastien Baumann ◽  
Nadia Bouchemal ◽  
Vincent Humblot ◽  
...  

Nanomedicine ◽  
2020 ◽  
Vol 15 (26) ◽  
pp. 2543-2561
Author(s):  
Shu-Jyuan Yang ◽  
Shu-Yi Tseng ◽  
Chung-Hao Wang ◽  
Tai-Horng Young ◽  
Ke-Cheng Chen ◽  
...  

Aim: Cells with CD133 overexpression, a theoretical cancer stem cells (CSCs) marker, have been shown to induce colorectal cancer (CRC) initiation and relapse. Therefore, the detection and treatment of CSCs are the most important factors in overcoming CRC. Materials & methods: Herein, we developed a magnetite-based nanomedicine (superparamagnetic iron oxide@poly(sodium styrene sulfonate)/irinotecan/human serum albumin-anti-CD133 nanoparticle) using loco-regional hyperthermia combined with chemotherapy for CRC- and CSC-specific targeting treatment. Results: The designed nanoparticles were highly biocompatible and exhibited a higher temperature increase rate under radiofrequency generator irradiation. The nanoparticles could be used as a T2-weighted magnetic resonance imaging contrast media, and also applied during hyperthermia and chemotherapy to display a synergistic anticancer effect. Conclusion: Therefore, the superparamagnetic iron oxide@poly(sodium styrene sulfonate)/irinotecan/human serum albumin-anti-CD133 nanoparticles are a powerful candidate for future antitumor strategies.


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