Design of biomaterials to enhance stem cell survival when transplanted into the damaged central nervous system

Soft Matter ◽  
2010 ◽  
Vol 6 (20) ◽  
pp. 4988 ◽  
Author(s):  
M. J. Cooke ◽  
K. Vulic ◽  
M. S. Shoichet
RSC Advances ◽  
2019 ◽  
Vol 9 (15) ◽  
pp. 8315-8325 ◽  
Author(s):  
Zhiping Qi ◽  
Wenlai Guo ◽  
Shuang Zheng ◽  
Chuan Fu ◽  
Yue Ma ◽  
...  

The mammalian central nervous system has a limited ability for self-repair under injury conditions.


2006 ◽  
Vol 166 (3) ◽  
pp. 495-503 ◽  
Author(s):  
Jeffrey A. Coderre ◽  
Gerard M. Morris ◽  
Peggy L. Micca ◽  
John W. Hopewell ◽  
Ilja Verhagen ◽  
...  

Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.


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