Monooxygenation by a thermophilic cytochrome P450 via direct electron donation from NADH

Metallomics ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 389 ◽  
Author(s):  
Hirotoshi Matsumura ◽  
Keisuke Matsuda ◽  
Nobuhumi Nakamura ◽  
Akashi Ohtaki ◽  
Hiromi Yoshida ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Electron Donation

Electron transfer in human cytochrome P450 reductase

2003 ◽  
Vol 31 (3) ◽  
pp. 497-501 ◽  
Author(s):  
A. Gutierrez ◽  
A. Grunau ◽  
M. Paine ◽  
A.W. Munro ◽  
C.R. Wolf ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Cytochrome P450 ◽  
Site Directed Mutagenesis ◽  
Cytochrome P450 Reductase ◽  
Cytochrome P450 Enzymes ◽  
P450 Reductase ◽  
Human Cytochrome ◽  
Redox Potentiometry ◽  
Electron Donation

Cytochrome P450 reductase (CPR) is a diflavin enzyme responsible for electron donation to mammalian cytochrome P450 enzymes in the endoplasmic reticulum. Dissection of the enzyme into functional domains and studies by site-directed mutagenesis have enabled detailed characterization of the mechanism of electron transfer using stopped-flow and equilibrium-perturbation methods, and redox potentiometry. These studies and the mechanism of electron transfer in CPR are reported herein.

scholarly journals Proximal Ligand Electron Donation and Reactivity of the Cytochrome P450 Ferric–Peroxo Anion

2012 ◽  
Vol 134 (15) ◽  
pp. 6673-6684 ◽  
Author(s):  
Santhosh Sivaramakrishnan ◽  
Hugues Ouellet ◽  
Hirotoshi Matsumura ◽  
Shenheng Guan ◽  
Pierre Moënne-Loccoz ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Ferric Peroxo ◽  
Electron Donation

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052457079-8
Author(s):  
Y. Nishiya ◽  
K. Hagihara ◽  
A. Kurihara ◽  
N. Okudaira ◽  
N.A. Farid ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Cytochrome ◽  
Cytochrome P450 2C19

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

2000 ◽  
Vol 86 (5) ◽  
pp. 215-221 ◽  
Author(s):  
Paivi Taavitsainen ◽  
Markku Anttila ◽  
Leena Nyman ◽  
Hari Karnani ◽  
Jarmo S. Salonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Vitro Study
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