Facile fabrication of magnetic metal–organic framework nanocomposites for potential targeted drug delivery

2011 ◽  
Vol 21 (11) ◽  
pp. 3843 ◽  
Author(s):  
Fei Ke ◽  
Yu-Peng Yuan ◽  
Ling-Guang Qiu ◽  
Yu-Hua Shen ◽  
An-Jian Xie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Metal Organic Framework ◽  
Magnetic Metal ◽  
Metal Organic ◽  
Facile Fabrication ◽  
Targeted Drug ◽  
Organic Framework

Antibody-directed metal-organic framework nanoparticles for targeted drug delivery

2020 ◽  
Vol 103 ◽  
pp. 223-236 ◽  
Author(s):  
Vladimir R. Cherkasov ◽  
Elizaveta N. Mochalova ◽  
Andrey V. Babenyshev ◽  
Julian M. Rozenberg ◽  
Ilya L. Sokolov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Targeted Drug ◽  
Organic Framework

scholarly journals Dual-ligated Metal Organic Framework as Novel Multifunctional Nanovehicle for Targeted Drug Delivery for Hepatic Cancer Treatment

2021 ◽  
Author(s):  
Mostafa Fytory ◽  
Kholoud K. Arafa ◽  
Waleed El Rouby ◽  
Ahmed Farghali ◽  
Mahmoud Abdel-Hafiez ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Tumor Targeting ◽  
Rational Design ◽  
Metal Organic Framework ◽  
Hepatic Cancer ◽  
Metal Organic ◽  
Targeted Drug ◽  
Multifunctional Nanocarriers ◽  
Microscopic Techniques

Abstract In the last decade, nanosized metal organic frameworks (NMOFs) have gained an increasing applicability as multifunctional nanocarriers for drug delivery in cancer therapy. However, only a limited number of platforms have been reported that can serve as an effective targeted drug delivery system (DDSs). Herein, we report rational design and construction of doxorubicin (DOX)-loaded nanoscale Zr (IV)-based NMOF (NH2-UiO-66) decorated with active tumor targeting moieties; folic acid (FA), lactobionic acid (LA), glycyrrhetinic acid (GA), and dual ligands of LA and GA, as efficient multifunctional DDSs for hepatocellular carcinoma (HCC) therapy. The success of modification was exhaustively validated by various structural, thermal and microscopic techniques. Biocompatibility studies indicated the safety of pristine NH2-UiO-66 against HSF cells whereas DOX-loaded dual-ligated NMOF was found to possess superior cytotoxicity against HepG2 cells which was further confirmed by flow cytometry. Moreover, fluorescence microscopy was used for monitoring cellular uptake in comparison to the non-ligated and mono-ligated NMOF. Additionally, the newly developed dual-ligated NMOF depicted a pH-responsiveness towards the DOX release. These findings open new avenues in designing various NMOF-based DDSs that actively target hepatic cancer to achieve precise therapy.

scholarly journals Fabrication of a hyaluronic acid conjugated metal organic framework for targeted drug delivery and magnetic resonance imaging

RSC Advances ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 6581-6589 ◽  
Author(s):  
Fangpeng Shu ◽  
Daojun Lv ◽  
Xian-Lu Song ◽  
Bin Huang ◽  
Chong Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Magnetic Resonance ◽  
Targeted Drug Delivery ◽  
Metal Organic Framework ◽  
Resonance Imaging ◽  
One Pot ◽  
Metal Organic ◽  
Targeted Drug

DOX-doped MOF nanoparticles were prepared via a one-pot reaction and successively anchored with Fe3+ and HA for simultaneous targeted drug delivery and MR imaging.

scholarly journals Dual-ligated metal organic framework as novel multifunctional nanovehicle for targeted drug delivery for hepatic cancer treatment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mostafa Fytory ◽  
Kholoud K. Arafa ◽  
Waleed M. A. El Rouby ◽  
Ahmed A. Farghali ◽  
Mahmoud Abdel-Hafiez ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Tumor Targeting ◽  
Rational Design ◽  
Metal Organic Framework ◽  
Hepatic Cancer ◽  
Metal Organic ◽  
Targeted Drug ◽  
Multifunctional Nanocarriers ◽  
Microscopic Techniques

AbstractIn the last decade, nanosized metal organic frameworks (NMOFs) have gained an increasing applicability as multifunctional nanocarriers for drug delivery in cancer therapy. However, only a limited number of platforms have been reported that can serve as an effective targeted drug delivery system (DDSs). Herein, we report rational design and construction of doxorubicin (DOX)-loaded nanoscale Zr (IV)-based NMOF (NH2-UiO-66) decorated with active tumor targeting moieties; folic acid (FA), lactobionic acid (LA), glycyrrhetinic acid (GA), and dual ligands of LA and GA, as efficient multifunctional DDSs for hepatocellular carcinoma (HCC) therapy. The success of modification was exhaustively validated by various structural, thermal and microscopic techniques. Biocompatibility studies indicated the safety of pristine NH2-UiO-66 against HSF cells whereas DOX-loaded dual-ligated NMOF was found to possess superior cytotoxicity against HepG2 cells which was further confirmed by flow cytometry. Moreover, fluorescence microscopy was used for monitoring cellular uptake in comparison to the non-ligated and mono-ligated NMOF. Additionally, the newly developed dual-ligated NMOF depicted a pH-responsiveness towards the DOX release. These findings open new avenues in designing various NMOF-based DDSs that actively target hepatic cancer to achieve precise therapy.

scholarly journals Facile Fabrication of Magnetic Metal-Organic Framework Composites for the Highly Selective Removal of Cationic Dyes

Materials ◽  
2018 ◽  
Vol 11 (5) ◽  
pp. 744 ◽  
Author(s):  
Huijun Li ◽  
Qingqing Li ◽  
Yaling He ◽  
Ning Zhang ◽  
Zhouqing Xu ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Selective Removal ◽  
Cationic Dyes ◽  
Magnetic Metal ◽  
Metal Organic ◽  
Facile Fabrication ◽  
Organic Framework
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