Unique electrochemically synthesized polypyrrole:poly(lactic-co-glycolic acid) blends for biomedical applications

2010 ◽  
Vol 20 (40) ◽  
pp. 8865 ◽  
Author(s):  
Leandro Forciniti ◽  
Nathalie K. Guimard ◽  
Sueyeon Lee ◽  
Christine E. Schmidt
Keyword(s):  
Biomedical Applications ◽  
Glycolic Acid

Bioadhesives in Biomedical Applications: A Critical Review

2020 ◽  
Vol 8 (2) ◽  
pp. 130-152
Author(s):  
Aishee Dey ◽  
Proma Bhattacharya ◽  
Sudarsan Neogi
Keyword(s):  
Clinical Trials ◽  
Biomedical Applications ◽  
Glycolic Acid ◽  
Mucus Layer ◽  
Poly Ethylene Glycol ◽  
Naturally Occurring ◽  
Long Time ◽  
Biomedical Industry ◽  
Poly Ethylene ◽  
Poor Adhesion

The necessity for a long time contact between the drug and mucus layer/epithelial cell or a combination of the two requires a bioadhesive. A bioadhesive is known to intensify contact between the two and help in controlled release of drugs. The conventionally used bioadhesives are known to have poor adhesion strength and can have toxic side effects. This review focuses on the various types of polymers and their composites for use as bioadhesives which can overcome the previously mentioned issues. These include some naturally occurring bioadhesives such as collagen, chitosan, albumin, dextran and some synthetic bioadhesives like gelatin, poly(ethylene glycol), poly(acrylic acid), poly(lactic-co-glycolic acid) based bioadhesives. The clinical trials prove the effectiveness of these bioadhesives and they are found to be more efficient than the commercial glues and hence possess great potential for use in the biomedical industry.

scholarly journals Poly(glycolide) multi-arm star polymers: Improved solubility via limited arm length

2010 ◽  
Vol 6 ◽  
Author(s):  
Florian K Wolf ◽  
Anna M Fischer ◽  
Holger Frey
Keyword(s):  
Molecular Weight ◽  
Ring Opening ◽  
Biomedical Applications ◽  
Weight Control ◽  
Glycolic Acid ◽  
Polymer Melt ◽  
Degree Of Polymerization ◽  
Star Block Copolymers ◽  
Grafting From ◽  
Low Solubility

Due to the low solubility of poly(glycolic acid) (PGA), its use is generally limited to the synthesis of random copolyesters with other hydroxy acids, such as lactic acid, or to applications that permit direct processing from the polymer melt. Insolubility is generally observed for PGA when the degree of polymerization exceeds 20. Here we present a strategy that allows the preparation of PGA-based multi-arm structures which significantly exceed the molecular weight of processable oligomeric linear PGA (<1000 g/mol). This was achieved by the use of a multifunctional hyperbranched polyglycerol (PG) macroinitiator and the tin(II)-2-ethylhexanoate catalyzed ring-opening polymerization of glycolide in the melt. With this strategy it is possible to combine high molecular weight with good molecular weight control (up to 16,000 g/mol, PDI = 1.4–1.7), resulting in PGA multi-arm star block copolymers containing more than 90 wt % GA. The successful linkage of PGA arms and PG core via this core first/grafting from strategy was confirmed by detailed NMR and SEC characterization. Various PG/glycolide ratios were employed to vary the length of the PGA arms. Besides fluorinated solvents, the materials were soluble in DMF and DMSO up to an average arm length of 12 glycolic acid units. Reduction in the T g and the melting temperature compared to the homopolymer PGA should lead to simplified processing conditions. The findings contribute to broadening the range of biomedical applications of PGA.

Surface modification of poly(glycolic acid) (PGA) for biomedical applications

2003 ◽  
Vol 92 (5) ◽  
pp. 933-937 ◽  
Author(s):  
Kyung-Bok Lee ◽  
Kuk Ro Yoon ◽  
Seong Ihl Woo ◽  
Insung S. Choi
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Glycolic Acid

scholarly journals PLGA – THE SMART POLYMER FOR DRUG DELIVERY

2021 ◽  
Vol 9 (5) ◽  
pp. 334-345
Author(s):  
N. Surya ◽  
S. Bhattacharyya
Keyword(s):  
Drug Delivery ◽  
Biodegradable Polymers ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Glycolic Acid ◽  
Delivery Systems ◽  
Nano Particles ◽  
Natural Polymers ◽  
Smart Polymer ◽  
Novel Drug

Polymers have become an integral part of novel drug delivery system. One such successful biodegradable polymer is poly lactic-co-glycolic acid (PLGA) which consists of polyesters of lactic acid and glycolic acid. It is one of the FDA-approved biodegradable polymers which is extensively used for therapeutic purposes in recent times.The aim. To illuminate researchers on the chemistry, novel properties and applications of PLGA in pharmaceutical fields.Materials and methods. Various internet sources like Science Direct, Scopus, Web of Science, PubMed and google scholar were used as the data source. The key words search was carried out for the following words and combinations: PLGA, Novel drug delivery, PLGA Nano particles, biomedical applications of PLGA.Results. Pharmaceutical and biomedical industries are flooded with the use of synthetic and natural polymers. The mechanical and viscoelastic properties of the polymers make them suitable for the temporal and spatial delivery of therapeutic agents for an extended period. Employment of copolymerization techniques lead to the modification of water solubility of the polymers and make them suitable for various applications of drug delivery systems. Biodegradable polymers due to their biocompatibility and biodegradable property have attracted their use in novel drug delivery systems. PLGA is one of them. PLGA is versatile as it can be fabricated into any size, shape, and can be used to encapsulate small molecules, tissue engineering, and bone repair, etc.Conclusion. The sensitivity and biodegradability of PLGA makes it a smart polymer for targeted and sustained delivery of drugs and in various biomedical applications.

Poly(α-hydroxyacids) in biomedical applications: synthesis and properties of lactic acid polymers

e-Polymers ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Rodica Lipsa ◽  
Nita Tudorachi ◽  
Cornelia Vasile
Keyword(s):  
Lactic Acid ◽  
Ring Opening ◽  
Biomedical Applications ◽  
Glycolic Acid ◽  
Recent Literature ◽  
Poly Lactic Acid ◽  
Biodegradation Rate ◽  
Degradation Behaviour ◽  
Food Applications ◽  
Us Fda

AbstractPoly( -hydroxy acids), especially poly(glycolic acid) (PGA), poly(lactic acid) (PLA) and their copolymers poly(lactic-co-glycolic acid) (PLGA) are novel class of commodity polymers, also used in biomedical applications. They can be synthesized with a controlled biodegradation rate and are biocompatible, bioresorbable and approved by US Food and Drug Administration (US FDA) for clinical use. Lactic acid polymers are developed in medicine (sutures, implants, orthopaedics, tissue engineering), pharmacy (controlled drug delivery systems) as well as in packaging, agriculture (mulch films, seed preservation), food applications, etc. The paper reviews recent literature data concerning lactic acid polymers synthesis (polycondensation, ring opening polymerization), physical (thermophysical, solubility, miscibility), mechanical properties, degradation behaviour, emphasizing on the poly(α -hydroxyacids) and lactic acid polymers applications in medicine and pharmacy.

scholarly journals Customizing poly(lactic-co-glycolic acid) particles for biomedical applications

2018 ◽  
Vol 73 ◽  
pp. 38-51 ◽  
Author(s):  
Edyta Swider ◽  
Olga Koshkina ◽  
Jurjen Tel ◽  
Luis J. Cruz ◽  
I. Jolanda M. de Vries ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Glycolic Acid
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