scholarly journals Synthesis of bioactive class II poly(γ-glutamic acid)/silica hybrids for bone regeneration

2010 ◽  
Vol 20 (40) ◽  
pp. 8952 ◽  
Author(s):  
Gowsihan Poologasundarampillai ◽  
Claudia Ionescu ◽  
Olga Tsigkou ◽  
Muthu Murugesan ◽  
Robert G. Hill ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Bone Regeneration ◽  
Class Ii ◽  
Silica Hybrids

scholarly journals Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease

2007 ◽  
Vol 5 (24) ◽  
pp. 749-758 ◽  
Author(s):  
James A Snyder ◽  
Eugene Demchuk ◽  
Erin C McCanlies ◽  
Christine R Schuler ◽  
Kathleen Kreiss ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Mhc Class Ii ◽  
Protein Interactions ◽  
Class Ii ◽  
Chronic Beryllium Disease ◽  
Glutamic Acid Residue ◽  
The One ◽  
Class Ii Antigen ◽  
Antigen Presenting ◽  
Beryllium Disease

Chronic beryllium disease (CBD) is a granulomatous lung disease that occurs primarily in workers who are exposed to beryllium dust or fumes. Although exposure to beryllium is a necessary factor in the pathobiology of CBD, alleles that code for a glutamic acid residue at the 69th position of the HLA-DPβ1 gene have previously been found to be associated with CBD. To date, 43 HLA-DPβ1 alleles that code for glutamic acid 69 (E69) have been described. Whether all of these E69 coding alleles convey equal risk of CBD is unknown. The present study demonstrates that, on the one hand, E69 alleloforms of major histocompatibility complex class II antigen-presenting proteins with the greatest negative surface charge convey the highest risk of CBD, and on the other hand, irrespective of allele, they convey equal risk of beryllium sensitization (BeS). In addition, the data suggest that the same alleles that cause the greatest risk of CBD are also important for the progression from BeS to CBD. Alleles convey the highest risk code for E26 in a constant region and for E69, aspartic acid 55 (D55), E56, D84 and E85 in hypervariable regions of the HLA-DPβ1 chain. Together with the calculated high binding affinities for beryllium, these results suggest that an adverse immune response, leading to CBD, is triggered by chemically specific metal–protein interactions.

Class II tubulin, the major brain β tubulin isotype is polyglutamylated on glutamic acid residue 435

FEBS Letters ◽  
1992 ◽  
Vol 308 (1) ◽  
pp. 101-105 ◽  
Author(s):  
Manfred Rüdiger ◽  
Uwe Plessman ◽  
Klaus-Dieter Klöppel ◽  
Jürgen Wehland ◽  
Klaus Weber
Keyword(s):  
Glutamic Acid ◽  
Class Ii ◽  
Glutamic Acid Residue ◽  
Tubulin Isotype ◽  
Β Tubulin

scholarly journals Electrospun Poly(γ–glutamic acid)/β–Tricalcium Phosphate Composite Fibrous Mats for Bone Regeneration

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 227 ◽  
Author(s):  
Chun-Hsu Yao ◽  
Shau-Pei Yang ◽  
Yueh-Sheng Chen ◽  
Kuo-Yu Chen
Keyword(s):  
Glutamic Acid ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Bone Growth ◽  
Weight Ratio ◽  
Cranial Bone ◽  
Cross Linking ◽  
Scanning Electron Micrographs ◽  
Electrospinning Technique

A poly(γ–glutamic acid)/β–tricalcium phosphate (γ–PGA/β–TCP) composite fibrous mat was fabricated using the electrospinning technique as a novel bone substitute. The mat was then cross-linked with cystamine in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide to improve its water-resistant ability. Scanning electron micrographs revealed that the γ–PGA/β–TCP fibers had a uniform morphology with diameters ranging from 0.64 ± 0.07 µm to 1.65 ± 0.16 µm. The average diameter of the fibers increased with increasing cross-linking time. Moreover, increasing the cross-linking time and decreasing the γ–PGA/β–TCP weight ratio decreased the swelling ratio and in vitro degradation rate of the composite fibrous mat. In vitro experiments with osteoblast-like MG-63 cells demonstrated that the mat with a γ–PGA/β–TCP weight ratio of 20 and cross-linked time of 24 h had a higher alkaline phosphatase activity and better cell adhesion. Furthermore, the rat cranial bone defect was created and treated with the γ–PGA/β–TCP composite fibrous mat to evaluate its potential in bone regeneration. After 8 weeks of implantation, micro computed tomography showed that the γ–PGA/β–TCP composite fibrous mat promoted new bone growth. These observations suggest that the γ–PGA/β–TCP composite fibrous mat has a potential application in bone tissue engineering.

scholarly journals Ductile silica/methacrylate hybrids for bone regeneration

2016 ◽  
Vol 4 (36) ◽  
pp. 6032-6042 ◽  
Author(s):  
Anthony L. B. Maçon ◽  
Siwei Li ◽  
Justin J. Chung ◽  
Amy Nommeots-Nomm ◽  
Anu K. Solanki ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Class Ii ◽  
Cross Linking ◽  
Scaffold Materials ◽  
New Generation

Hybrids consisting of co-networks of high cross-linking density polymethacrylate and silica (class II hybrid) were synthesised as a potential new generation of scaffold materials.

Fabrication and in vitro characterization of electrospun poly (γ-glutamic acid)-silica hybrid scaffolds for bone regeneration

Polymer ◽  
2016 ◽  
Vol 91 ◽  
pp. 106-117 ◽  
Author(s):  
Chunxia Gao ◽  
Shingo Ito ◽  
Akiko Obata ◽  
Toshihisa Mizuno ◽  
Julian R. Jones ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Bone Regeneration ◽  
In Vitro Characterization ◽  
Hybrid Scaffolds ◽  
Silica Hybrid

Treatment of periodontal furcation defects. (II) Bone regeneration in mandibular class II defects

1988 ◽  
Vol 15 (4) ◽  
pp. 232-239 ◽  
Author(s):  
Bernard Gantes ◽  
Michael Martin ◽  
Steve Garrett ◽  
Jan Egelberg
Keyword(s):  
Bone Regeneration ◽  
Class Ii ◽  
Furcation Defects
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